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dc.contributor.authorTsantes, Argirio E.en
dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorBagos, Pantelis G.en
dc.contributor.authorVaiopoulos, G.en
dc.contributor.authorTravlou, Anthi S.en
dc.creatorTsantes, Argirio E.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorBagos, Pantelis G.en
dc.creatorVaiopoulos, G.en
dc.creatorTravlou, Anthi S.en
dc.date.accessioned2018-06-22T09:53:23Z
dc.date.available2018-06-22T09:53:23Z
dc.date.issued2007
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41812
dc.description.abstractBackground: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism of the GPla gene is considered a genetic marker of the platelet GPla/lla density. The importance of the GPla gene C807T polymorphism as a genetic risk factor for coronary artery disease (CAD) remains controversial. To assess this association, we performed a meta-analysis of published data. Methods: A comprehensive meta-analysis of 19 studies, with a total sample of 13 835 subjects using random effects models. Results: The C versus T allele contrast gave an OR of 0.998 with 95% Cl 0.937-1.064. Similarly, comparing the C homozygotes with the T homozygotes, the CC genotype versus the others and the TT genotype versus the rest, no evidence of any gene-disease association was obtained. Furthermore, the meta-regression analysis did not disclose any variable that could modify the role of this polymorphism in the development of CAD. Conclusion: Our findings support the view that C807T polymorphism of the GPla gene is not a significant risk factor for CAD, either alone or in combination with other major cardiovascular risk factors. © 2006 Elsevier Ireland Ltd. All rights reserved.en
dc.language.isoengen
dc.sourceInternational journal of cardiologyen
dc.subjectArticleen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectPriority journalen
dc.subjectClinical trialen
dc.subjectStatistical significanceen
dc.subjectConfidence intervalen
dc.subjectSystematic reviewen
dc.subjectAlleleen
dc.subjectDna polymorphismen
dc.subjectGenotypeen
dc.subjectMeta analysisen
dc.subjectOdds ratioen
dc.subjectPolymorphismen
dc.subjectStatistical analysisen
dc.subjectGeneticen
dc.subjectRisk factorsen
dc.subjectRisk factoren
dc.subjectCardiovascular risken
dc.subjectDisease associationen
dc.subjectCoronary artery diseaseen
dc.subjectGene frequencyen
dc.subjectAlpha2 integrinen
dc.subjectIntegrin alpha2en
dc.subjectCoronary arteriosclerosisen
dc.subjectGenetic disorderen
dc.subjectGpla c807t polymorphismen
dc.subjectHomozygosityen
dc.titleLack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ijcard.2006.06.047
dc.description.volume118
dc.description.issue2
dc.description.startingpage189
dc.description.endingpage196
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325


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