dc.contributor.author | Tsantes, Argirio E. | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Bagos, Pantelis G. | en |
dc.contributor.author | Vaiopoulos, G. | en |
dc.contributor.author | Travlou, Anthi S. | en |
dc.creator | Tsantes, Argirio E. | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Bagos, Pantelis G. | en |
dc.creator | Vaiopoulos, G. | en |
dc.creator | Travlou, Anthi S. | en |
dc.date.accessioned | 2018-06-22T09:53:23Z | |
dc.date.available | 2018-06-22T09:53:23Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41812 | |
dc.description.abstract | Background: The platelet-collagen receptor, glycoprotein (GP) la/lla plays a crucial role in the adhesion of platelets to fibrillar collagen, an event contributing to the pathogenesis of thrombosis. The C807T polymorphism of the GPla gene is considered a genetic marker of the platelet GPla/lla density. The importance of the GPla gene C807T polymorphism as a genetic risk factor for coronary artery disease (CAD) remains controversial. To assess this association, we performed a meta-analysis of published data. Methods: A comprehensive meta-analysis of 19 studies, with a total sample of 13 835 subjects using random effects models. Results: The C versus T allele contrast gave an OR of 0.998 with 95% Cl 0.937-1.064. Similarly, comparing the C homozygotes with the T homozygotes, the CC genotype versus the others and the TT genotype versus the rest, no evidence of any gene-disease association was obtained. Furthermore, the meta-regression analysis did not disclose any variable that could modify the role of this polymorphism in the development of CAD. Conclusion: Our findings support the view that C807T polymorphism of the GPla gene is not a significant risk factor for CAD, either alone or in combination with other major cardiovascular risk factors. © 2006 Elsevier Ireland Ltd. All rights reserved. | en |
dc.language.iso | eng | en |
dc.source | International journal of cardiology | en |
dc.subject | Article | en |
dc.subject | Meta-analysis | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Priority journal | en |
dc.subject | Clinical trial | en |
dc.subject | Statistical significance | en |
dc.subject | Confidence interval | en |
dc.subject | Systematic review | en |
dc.subject | Allele | en |
dc.subject | Dna polymorphism | en |
dc.subject | Genotype | en |
dc.subject | Meta analysis | en |
dc.subject | Odds ratio | en |
dc.subject | Polymorphism | en |
dc.subject | Statistical analysis | en |
dc.subject | Genetic | en |
dc.subject | Risk factors | en |
dc.subject | Risk factor | en |
dc.subject | Cardiovascular risk | en |
dc.subject | Disease association | en |
dc.subject | Coronary artery disease | en |
dc.subject | Gene frequency | en |
dc.subject | Alpha2 integrin | en |
dc.subject | Integrin alpha2 | en |
dc.subject | Coronary arteriosclerosis | en |
dc.subject | Genetic disorder | en |
dc.subject | Gpla c807t polymorphism | en |
dc.subject | Homozygosity | en |
dc.title | Lack of association between the platelet glycoprotein Ia C807T gene polymorphism and coronary artery disease: A meta-analysis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ijcard.2006.06.047 | |
dc.description.volume | 118 | |
dc.description.issue | 2 | |
dc.description.startingpage | 189 | |
dc.description.endingpage | 196 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Bagos, Pantelis G. [0000-0003-4935-2325] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0003-4935-2325 | |