dc.contributor.author | Tsantes, Argirio E. | en |
dc.contributor.author | Tsangaris, I. | en |
dc.contributor.author | Kopterides, Petros | en |
dc.contributor.author | Nikolopoulos, Georgios K. | en |
dc.contributor.author | Kalamara, Eleni | en |
dc.contributor.author | Antonakos, Georgios | en |
dc.contributor.author | Kapsimali, Violetta | en |
dc.contributor.author | Gialeraki, Argiri | en |
dc.contributor.author | Dimopoulou, Ioanna | en |
dc.contributor.author | Orfanos, S. | en |
dc.contributor.author | Dima, Kleanthi | en |
dc.contributor.author | Travlou, Anthi S. | en |
dc.contributor.author | Armaganidis, Apostolos | en |
dc.creator | Tsantes, Argirio E. | en |
dc.creator | Tsangaris, I. | en |
dc.creator | Kopterides, Petros | en |
dc.creator | Nikolopoulos, Georgios K. | en |
dc.creator | Kalamara, Eleni | en |
dc.creator | Antonakos, Georgios | en |
dc.creator | Kapsimali, Violetta | en |
dc.creator | Gialeraki, Argiri | en |
dc.creator | Dimopoulou, Ioanna | en |
dc.creator | Orfanos, S. | en |
dc.creator | Dima, Kleanthi | en |
dc.creator | Travlou, Anthi S. | en |
dc.creator | Armaganidis, Apostolos | en |
dc.date.accessioned | 2018-06-22T09:53:24Z | |
dc.date.available | 2018-06-22T09:53:24Z | |
dc.date.issued | 2012 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41820 | |
dc.description.abstract | Background: In critically ill patients independent studies have shown contradictory findings regarding the prognostic significance of the D/D genotype of the I/D angiotensin converting enzyme (ACE) polymorphism. The study aim was to evaluate the effect of both ACE I/D polymorphism and ACE serum levels on the clinical outcomes of critically ill septic patients. Methods: This study recruited 186 Caucasian patients with sepsis, severe sepsis or septic shock. Epidemiological, clinical data, co-morbidities and severity scores were recorded. Measurements of serum ACE activity and genotyping for ACE I/D polymorphism were carried out. Primary outcomes were the 28-and the 90-day mortality; secondary outcomes included the number of days without renal or cardiovascular failure and ventilation-free days over the 28-day period following study enrolment. Results: Neither 28-nor 90-day mortality were associated with ACE I/D polymorphism (p=0.59 and 0.34, respectively) or circulating ACE levels (p=0.17 and 0.25, respectively). Similarly, ACE polymorphism and levels were not related to ventilation-free days (p=0.14 and 0.25, respectively), days without cardiovascular failure (p=0.14 and 0.81, respectively) and days without renal failure (p=0.64 and 0.27, respectively). Conclusions: Neither ACE I/D polymorphism nor serum ACE levels seem to be significant prognostic factors of clinical outcomes in septic, critically ill patients. © 2012 by Walter de Gruyter Berlin Boston. | en |
dc.language.iso | eng | en |
dc.source | Clinical Chemistry and Laboratory Medicine | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Humans | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Middle aged | en |
dc.subject | Priority journal | en |
dc.subject | Prognosis | en |
dc.subject | Outcome assessment | en |
dc.subject | Male | en |
dc.subject | Mortality | en |
dc.subject | Sepsis | en |
dc.subject | Caucasian | en |
dc.subject | Dna polymorphism | en |
dc.subject | Genotype | en |
dc.subject | Polymorphism | en |
dc.subject | Genetic | en |
dc.subject | Clinical assessment | en |
dc.subject | Disease severity | en |
dc.subject | Enzyme blood level | en |
dc.subject | Prednisolone | en |
dc.subject | Septic shock | en |
dc.subject | Artificial ventilation | en |
dc.subject | Critically ill patient | en |
dc.subject | Critical illness | en |
dc.subject | Gene deletion | en |
dc.subject | Heart failure | en |
dc.subject | Dipeptidyl carboxypeptidase | en |
dc.subject | Peptidyl-dipeptidase a | en |
dc.subject | Scoring system | en |
dc.subject | Leukemia | en |
dc.subject | Myeloid | en |
dc.subject | Comorbidity | en |
dc.subject | Epidemiological data | en |
dc.subject | Enzyme activity | en |
dc.subject | Kidney failure | en |
dc.subject | Gene insertion | en |
dc.subject | Acute | en |
dc.subject | Angiotensin converting enzyme | en |
dc.subject | I/d polymorphism | en |
dc.subject | Steroid therapy | en |
dc.title | Angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism and circulating ACE levels are not associated with outcome in critically ill septic patients | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1515/cclm.2011.752 | |
dc.description.volume | 50 | |
dc.description.issue | 2 | |
dc.description.startingpage | 293 | |
dc.description.endingpage | 299 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Nikolopoulos, Georgios K.[0000-0002-3307-0246] | |
dc.contributor.orcid | Kopterides, Petros [0000-0002-7682-4482] | |
dc.contributor.orcid | Dima, Kleanthi [0000-0001-5284-115X] | |
dc.contributor.orcid | Armaganidis, Apostolos [0000-0002-6630-2648] | |
dc.contributor.orcid | Kalamara, Eleni [0000-0002-5444-3056] | |
dc.gnosis.orcid | 0000-0002-3307-0246 | |
dc.gnosis.orcid | 0000-0002-7682-4482 | |
dc.gnosis.orcid | 0000-0001-5284-115X | |
dc.gnosis.orcid | 0000-0002-6630-2648 | |
dc.gnosis.orcid | 0000-0002-5444-3056 | |