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Specific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitro

dc.contributor.authorMartinez, Luis R.en
dc.contributor.authorChristaki, Eirinien
dc.contributor.authorCasadevall, Arturoen
dc.creatorMartinez, Luis R.en
dc.creatorChristaki, Eirinien
dc.creatorCasadevall, Arturoen
dc.date.accessioned2018-06-22T09:53:59Z
dc.date.available2018-06-22T09:53:59Z
dc.date.issued2006
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42138
dc.description.abstractThe fungus Cryptococcus neoformans possesses a polysaccharide capsule and can form biofilms on medical devices. We investigated the efficacy that the combination of a specific antibody to the capsular polysaccharide and antifungal therapy has against cryptococcal biofilms. The antibody enhanced the susceptibility of planktonic cells to antifungal agents, but an antagonistic effect was observed for combination therapy against C. neoformans biofilms. Our findings suggest that antibody therapies for infectious diseases that involve biofilms may antagonize certain antimicrobial therapies, and they also imply that products of the immune response may contribute to drug resistance of biofilms formed in vivo. © 2006 by the Infectious Diseases Society of America. All rights reserved.en
dc.language.isoengen
dc.sourceJournal of Infectious Diseasesen
dc.subjectArticleen
dc.subjectPriority journalen
dc.subjectDrug effecten
dc.subjectDrug efficacyen
dc.subjectDrug resistanceen
dc.subjectAntibodiesen
dc.subjectNonhumanen
dc.subjectDrug mechanismen
dc.subjectImmune responseen
dc.subjectAnimal cellen
dc.subjectAntigen presentationen
dc.subjectPhagocytosisen
dc.subjectAntifungal agenten
dc.subjectIn vitro studyen
dc.subjectAmphotericin ben
dc.subjectAntibody specificityen
dc.subjectAntifungal activityen
dc.subjectAntifungal agentsen
dc.subjectBiofilmen
dc.subjectBiofilmsen
dc.subjectCryptococcosisen
dc.subjectCryptococcus neoformansen
dc.subjectCyclicen
dc.subjectFungalen
dc.subjectGlucuronoxylomannanen
dc.subjectMannansen
dc.subjectPeptidesen
dc.subjectPlanktonen
dc.subjectPolysaccharideen
dc.titleSpecific antibody to Cryptococcus neoformans glucurunoxylomannan antagonizes antifungal drug action against cryptococcal biofilms in vitroen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1086/504722
dc.description.volume194
dc.description.issue2
dc.description.startingpage261
dc.description.endingpage266
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidChristaki, Eirini [0000-0002-8152-6367]
dc.contributor.orcidCasadevall, Arturo [0000-0002-9402-9167]
dc.gnosis.orcid0000-0002-8152-6367
dc.gnosis.orcid0000-0002-9402-9167


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