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dc.contributor.authorMinas, V.en
dc.contributor.authorRolaki, A.en
dc.contributor.authorKalantaridou, S. N.en
dc.contributor.authorSidiropoulos, J.en
dc.contributor.authorMitrou, Sotiriosen
dc.contributor.authorPetsas, G.en
dc.contributor.authorJeschke, U.en
dc.contributor.authorParaskevaidis, E.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorChrousos, George P.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorMakrigiannakis, A.en
dc.creatorMinas, V.en
dc.creatorRolaki, A.en
dc.creatorKalantaridou, S. N.en
dc.creatorSidiropoulos, J.en
dc.creatorMitrou, Sotiriosen
dc.creatorPetsas, G.en
dc.creatorJeschke, U.en
dc.creatorParaskevaidis, E.en
dc.creatorFountzilas, Georgeen
dc.creatorChrousos, George P.en
dc.creatorPavlidis, Nicholasen
dc.creatorMakrigiannakis, A.en
dc.date.accessioned2018-06-22T09:54:03Z
dc.date.available2018-06-22T09:54:03Z
dc.date.issued2007
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42170
dc.description.abstractAlthough corticotropin-releasing hormone (CRH) and Fas ligand (FasL) have been documented in ovarian carcinoma, a clear association with tumour progression and immuno-escape has not been established. FasL plays an important role in promoting tumour cells' ability to counterattack immune cells. Here, we examined immunohistochemically the expression of CRH, CRHR1, CRHR2 and FasL in 47 human ovarian cancer cases. The ovarian cancer cell lines OvCa3 and A2780 were further used to test the hypothesis that CRH might contribute to the immune privilege of ovarian tumours, by modulating FasL expression on the cancer cells. We found that CRH, CRHR1, CRHR2 and FasL were expressed in 68.1, 70.2, 63.8 and 63.8% of the cases respectively. Positivity for CRH or FasL expression was associated with higher tumour stage. Finally, CRH increased the expression of FasL in OvCa3 and A2780 cells through CRHR1 thereby potentiated their ability to induce apoptosis of activated peripheral blood lymphocytes. Corticotropin-releasing hormone produced by human ovarian cancer might favour survival and progression of the tumour by promoting its immune privilege. These findings support the hypothesis that CRHR1 antagonists could potentially be used against ovarian cancer. © 2007 Cancer Research UK.en
dc.language.isoengen
dc.sourceBritish journal of canceren
dc.subjectArticleen
dc.subjectFemaleen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectControlled studyen
dc.subjectCancer growthen
dc.subjectNeoplasm stagingen
dc.subjectOvarian canceren
dc.subjectOvarian neoplasmsen
dc.subjectOvary canceren
dc.subjectPriority journalen
dc.subjectClinical articleen
dc.subjectHuman tissueen
dc.subjectCancer stagingen
dc.subjectNeoplasticen
dc.subjectCorrelation analysisen
dc.subjectImmunohistochemistryen
dc.subjectProtein expressionen
dc.subjectGene expression regulationen
dc.subjectReceptorsen
dc.subjectFluorescent antibody techniqueen
dc.subjectApoptosisen
dc.subjectHuman cellen
dc.subjectImmune responseen
dc.subjectRnaen
dc.subjectPeripheral lymphocyteen
dc.subjectMessenger rnaen
dc.subjectMessengeren
dc.subjectTumoren
dc.subjectBlottingen
dc.subjectWesternen
dc.subjectCancer cell cultureen
dc.subjectCaspasesen
dc.subjectCell lineen
dc.subjectCell proliferationen
dc.subjectCorticotropin releasing factoren
dc.subjectCorticotropin releasing factor receptor 1en
dc.subjectCorticotropin releasing factor receptor 2en
dc.subjectCorticotropin-releasing hormoneen
dc.subjectCrhen
dc.subjectFas liganden
dc.subjectFas ligand proteinen
dc.subjectImmune privilegeen
dc.subjectIndirecten
dc.subjectLymphocyte activationen
dc.subjectLymphocytesen
dc.subjectRegulatory mechanismen
dc.subjectReverse transcriptase polymerase chain reactionen
dc.subjectUp-regulationen
dc.titleIntratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulationen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/sj.bjc.6603918
dc.description.volume97
dc.description.issue5
dc.description.startingpage637
dc.description.endingpage645
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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