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dc.contributor.authorNikolopoulos, Georgios K.en
dc.contributor.authorDimou, Niki L.en
dc.contributor.authorHamodrakas, Stavros J.en
dc.contributor.authorBagos, Pantelis G.en
dc.creatorNikolopoulos, Georgios K.en
dc.creatorDimou, Niki L.en
dc.creatorHamodrakas, Stavros J.en
dc.creatorBagos, Pantelis G.en
dc.date.accessioned2018-06-22T09:54:07Z
dc.date.available2018-06-22T09:54:07Z
dc.date.issued2008
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42200
dc.description.abstractAim: We conducted a systematic review and a meta-analysis, in order to investigate the potential association of cytokine gene polymorphisms with either aggressive or chronic periodontal disease. Material and Methods: A comprehensive literature search was performed. We retrieved a total of 53 studies summarizing information about 4178 cases and 4590 controls. Six polymorphisms were included in our meta-analysis which are the following: IL-1A G[4845]T, IL-1A C[-889]T, IL-1B C[3953/4]T, IL-1B T[-511]C, IL-6 G[-174]C and TNFA G[-308]A. Random effect methods were used for the analysis. We calculated the specific odds ratios along with their 95% confidence intervals to compare the distribution of alleles and genotypes between cases and controls. Results and Conclusions: Using random effect methods we found statistically significant association of IL-1A C[-889]T and IL-1B C[3953/4]T polymorphisms with chronic periodontal disease without any evidence of publication bias or significant statistical heterogeneity. A weak positive association was also found concerning IL-1B T[-511]C and chronic periodontal disease. No association was found for all the cytokines examined as far as the aggressive form of the disease is concerned. Future studies may contribute to the investigation of the potential multigenetic predisposition of the disease and reinforce our findings. © 2008 The Authors.en
dc.language.isoengen
dc.sourceJournal of clinical periodontologyen
dc.subjectArticleen
dc.subjectMeta-analysisen
dc.subjectHumanen
dc.subjectHumansen
dc.subjectAlleleen
dc.subjectGenotypeen
dc.subjectMeta analysisen
dc.subjectPolymorphismen
dc.subjectAdenineen
dc.subjectCytosineen
dc.subjectGeneticen
dc.subjectGenetic polymorphismen
dc.subjectGuanineen
dc.subjectThymineen
dc.subjectInterleukin 1betaen
dc.subjectInterleukin 6en
dc.subjectComparative studyen
dc.subjectImmunologyen
dc.subjectGeneticsen
dc.subjectTumor necrosis factor alphaen
dc.subjectChronic periodontitisen
dc.subjectPeriodontitisen
dc.subjectAllelesen
dc.subjectInterleukin-6en
dc.subjectCytokineen
dc.subjectInterleukin 1alphaen
dc.subjectInterleukin derivativeen
dc.subjectInterleukin-1alphaen
dc.subjectInterleukin-1betaen
dc.subjectInterleukinsen
dc.subjectPeriodontitiesen
dc.subjectTumor necrosis factor-alphaen
dc.titleCytokine gene polymorphisms in periodontal disease: A meta-analysis of 53 studies including 4178 cases and 4590 controlsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/j.1600-051X.2008.01298.x
dc.description.volume35
dc.description.issue9
dc.description.startingpage754
dc.description.endingpage767
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidNikolopoulos, Georgios K.[0000-0002-3307-0246]
dc.contributor.orcidBagos, Pantelis G. [0000-0003-4935-2325]
dc.gnosis.orcid0000-0002-3307-0246
dc.gnosis.orcid0000-0003-4935-2325


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