dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Kalef-Ezra, J. A. | en |
dc.contributor.author | Briassoulis, E. Ch | en |
dc.contributor.author | Skarlos, Dimosthenis V. | en |
dc.contributor.author | Kosmidis, Paraskevas A. | en |
dc.contributor.author | Saferiadis, K. | en |
dc.contributor.author | Bairaktari, Eleni Th | en |
dc.contributor.author | Bafaloukos, Dimitrios | en |
dc.contributor.author | Maravegias, A. | en |
dc.contributor.author | Theoharis, D. | en |
dc.contributor.author | Fountzilas, George | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Kalef-Ezra, J. A. | en |
dc.creator | Briassoulis, E. Ch | en |
dc.creator | Skarlos, Dimosthenis V. | en |
dc.creator | Kosmidis, Paraskevas A. | en |
dc.creator | Saferiadis, K. | en |
dc.creator | Bairaktari, Eleni Th | en |
dc.creator | Bafaloukos, Dimitrios | en |
dc.creator | Maravegias, A. | en |
dc.creator | Theoharis, D. | en |
dc.creator | Fountzilas, George | en |
dc.date.accessioned | 2018-06-22T09:54:18Z | |
dc.date.available | 2018-06-22T09:54:18Z | |
dc.date.issued | 1994 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42289 | |
dc.description.abstract | We have retrospectively evaluated six serum tumor markers in 85 patients with carcinoma of unknown primary. The serum levels of carcinoembryonic antigen (CEA), CA 19‐9, CA 15‐3, CA 125, β‐chorionic gonadotropin (β‐HCG) and α‐fetoprotein (AFP) were related with the histological pattern (undifferentiated carcinoma or adenocarcinoma), the number and the site of metastases, as well as the response to chemotherapy and the patients' survival. More than 40% of the patients had increased serum levels of all six tumor markers, except of AFP which was found to be increased in only 17% of them. Increased levels of CA 19‐9 were related to metastatic adenocarcinoma, whereas CA 19‐9 and CA 15‐3 had a relationship with more advanced disease. Patients with liver involvement had higher mean levels of CEA and CA 19‐9 as compared to those with nodal disease. None of these markers was found to have a predictive value for response to chemotherapy or survival. Although the present study has a retrospective nature, it allows us to conclude that patients with CUP have a nonspecific over‐expression of the above serum tumor markers and that routine use of these markers does not offer any diagnostic or prognostic assistance. © 1994 wiley‐Liss, lnc. Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company | en |
dc.language.iso | eng | en |
dc.source | Medical and pediatric oncology | en |
dc.subject | Article | en |
dc.subject | Human | en |
dc.subject | Neoplasms | en |
dc.subject | Adult | en |
dc.subject | Female | en |
dc.subject | Major clinical study | en |
dc.subject | Advanced cancer | en |
dc.subject | Cancer survival | en |
dc.subject | Neoplasm | en |
dc.subject | Predictive value of tests | en |
dc.subject | Priority journal | en |
dc.subject | Prognosis | en |
dc.subject | Retrospective studies | en |
dc.subject | Lung neoplasms | en |
dc.subject | Survival rate | en |
dc.subject | Carcinoma | en |
dc.subject | Male | en |
dc.subject | Antigens | en |
dc.subject | Lymph node metastasis | en |
dc.subject | Liver neoplasms | en |
dc.subject | Liver metastasis | en |
dc.subject | Adenocarcinoma | en |
dc.subject | Biological | en |
dc.subject | Tumor markers | en |
dc.subject | Unknown primary | en |
dc.subject | Cancer localization | en |
dc.subject | Undifferentiated carcinoma | en |
dc.subject | Bone neoplasms | en |
dc.subject | Middle age | en |
dc.subject | Alpha fetoprotein | en |
dc.subject | Chorionic gonadotropin beta subunit | en |
dc.subject | Carcinoembryonic antigen | en |
dc.subject | Carcinoma of unknown primary | en |
dc.subject | Linear models | en |
dc.subject | Lymph nodes | en |
dc.subject | Ca 125 antigen | en |
dc.subject | Ca 15-3 antigen | en |
dc.subject | Ca 19-9 antigen | en |
dc.subject | Alpha-fetoproteins | en |
dc.subject | Antigen expression | en |
dc.subject | Carbohydrate | en |
dc.subject | Central nervous system neoplasms | en |
dc.subject | Chorionic gonadotropin | en |
dc.subject | Peritoneal neoplasms | en |
dc.subject | Serum tumor markers | en |
dc.subject | Tumor-associated | en |
dc.title | Evaluation of six tumor markers in patients with carcinoma of unknown primary | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/mpo.2950220303 | |
dc.description.volume | 22 | |
dc.description.issue | 3 | |
dc.description.startingpage | 162 | |
dc.description.endingpage | 167 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |