dc.contributor.author | Pentheroudakis, George | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.creator | Pentheroudakis, George | en |
dc.creator | Pavlidis, Nicholas | en |
dc.date.accessioned | 2018-06-22T09:54:25Z | |
dc.date.available | 2018-06-22T09:54:25Z | |
dc.date.issued | 2005 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/42348 | |
dc.description.abstract | Leptomeningeal carcinomatosis is defined as malignant infiltration of the pia matter and arachnoid membrane. Leukaemias and lymphomas, lung, breast cancer and melanoma are the primary tumours commonly associated with leptomeningeal carcinomatosis. Diagnosis is based on compatible symptoms and signs, cytological evidence of malignancy in the cerebrospinal fluid, and neuroimaging studies. Treatment is largely palliative (median survival 2 - 4 months). Patients with lympomatous or leukaemic meningitis, chemosensitive tumours such as breast cancer, low tumour burden, minimal neurological deficits, good performance status and controllable systemic disease survive longer with occasional long-term responses. Available treatment options include focal radiation therapy to CNS sites of bulky, symptomatic or obstructive meningeal deposits, intrathecal cytotoxic therapy and systemic chemotherapy. No evidence of superiority of intrathecal treatment compared with best palliative care (including radiation therapy and systemic treatment) is available from clinical trials. Novel treatment approaches include intrathecal liposomal Ara-C, the development of new cytotoxic compounds, signal transduction inhibitors and monoclonal antibodies for intrathecal or systemic use. Until data from multi-centre randomised trials are available, rationalisation of therapy should be done by stratifying patients to prognostic groups. High-risk patients will only survive for a few weeks and are better managed with supportive measures, whereas low-risk patients justify vigorous cerebrospinal fluid-directed treatment combined with radiation therapy and systemic chemotherapy. © 2005 Ashley Publications Ltd. | en |
dc.language.iso | eng | en |
dc.source | Expert opinion on pharmacotherapy | en |
dc.subject | Management | en |
dc.subject | Algorithms | en |
dc.subject | Antineoplastic agents | en |
dc.subject | Cytarabine | en |
dc.subject | Human | en |
dc.subject | Methotrexate | en |
dc.subject | Palliative care | en |
dc.subject | Adenocarcinoma | en |
dc.subject | Humans | en |
dc.subject | Breast cancer | en |
dc.subject | Cancer survival | en |
dc.subject | Computer assisted tomography | en |
dc.subject | Drug response | en |
dc.subject | Prognosis | en |
dc.subject | Antiemetic agent | en |
dc.subject | Bone marrow suppression | en |
dc.subject | Clinical trial | en |
dc.subject | Drug efficacy | en |
dc.subject | Mucosa inflammation | en |
dc.subject | Topotecan | en |
dc.subject | Intravenous | en |
dc.subject | Nephrotoxicity | en |
dc.subject | Dexamethasone | en |
dc.subject | Drug dose regimen | en |
dc.subject | Fever | en |
dc.subject | Liver toxicity | en |
dc.subject | Review | en |
dc.subject | Folinic acid | en |
dc.subject | Irinotecan | en |
dc.subject | Temozolomide | en |
dc.subject | Trastuzumab | en |
dc.subject | Carcinoma | en |
dc.subject | Injections | en |
dc.subject | Cerebrospinal fluid analysis | en |
dc.subject | Lymphoma | en |
dc.subject | Vomiting | en |
dc.subject | Cancer risk | en |
dc.subject | Randomized controlled trials | en |
dc.subject | Nausea | en |
dc.subject | High risk population | en |
dc.subject | Risk factor | en |
dc.subject | Carcinogenesis | en |
dc.subject | Disease association | en |
dc.subject | Vasculotropin | en |
dc.subject | Nuclear magnetic resonance imaging | en |
dc.subject | Malignancy | en |
dc.subject | Lactate dehydrogenase | en |
dc.subject | Antimetabolites | en |
dc.subject | Antineoplastic | en |
dc.subject | Alkylating | en |
dc.subject | Drug half life | en |
dc.subject | Combined modality therapy | en |
dc.subject | Steroid | en |
dc.subject | Carcinoembryonic antigen | en |
dc.subject | Headache | en |
dc.subject | Laboratory diagnosis | en |
dc.subject | Diagnostic accuracy | en |
dc.subject | Hydrocortisone | en |
dc.subject | Rituximab | en |
dc.subject | Reverse transcription polymerase chain reaction | en |
dc.subject | Enzyme inhibitors | en |
dc.subject | Dna topoisomerases | en |
dc.subject | Dermatitis | en |
dc.subject | Sensitivity and specificity | en |
dc.subject | Leukemia | en |
dc.subject | Thiotepa | en |
dc.subject | Life expectancy | en |
dc.subject | Neuroimaging | en |
dc.subject | Drug elimination | en |
dc.subject | Arachnoiditis | en |
dc.subject | Carcinomatous meningitis | en |
dc.subject | Leptomeninx | en |
dc.subject | Leukoencephalopathy | en |
dc.subject | Meningeal neoplasms | en |
dc.subject | Spinal | en |
dc.subject | Cytology | en |
dc.subject | Antipyretic agent | en |
dc.subject | Drug formulation | en |
dc.subject | Beta 2 microglobulin | en |
dc.subject | Spinal cord disease | en |
dc.subject | Arachnoid cysts | en |
dc.subject | Aseptic meningitis | en |
dc.subject | Cerebellum disease | en |
dc.subject | Cranial irradiation | en |
dc.subject | Delayed-action preparations | en |
dc.subject | Leptomeningeal | en |
dc.subject | Mafosfamide | en |
dc.subject | Meningeal metastasis | en |
dc.subject | Meningism | en |
dc.subject | Molecular mechanics | en |
dc.subject | Myelin basic protein | en |
dc.subject | Photophobia | en |
dc.subject | Type i | en |
dc.title | Management of leptomeningeal malignancy | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1517/14656566.6.7.1115 | |
dc.description.volume | 6 | |
dc.description.issue | 7 | |
dc.description.startingpage | 1115 | |
dc.description.endingpage | 1125 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.contributor.orcid | Pentheroudakis, George [0000-0002-6632-2462] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |
dc.gnosis.orcid | 0000-0002-6632-2462 | |