Show simple item record

dc.contributor.authorPentheroudakis, Georgeen
dc.contributor.authorSpector, Y.en
dc.contributor.authorKrikelis, D.en
dc.contributor.authorKotoula, V.en
dc.contributor.authorMeiri, E.en
dc.contributor.authorMalamou-Mitsi, Vassiliki D.en
dc.contributor.authorFountzilas, Georgeen
dc.contributor.authorSanden, M.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorBenjamin, H.en
dc.contributor.authorAharonov, R.en
dc.creatorPentheroudakis, Georgeen
dc.creatorSpector, Y.en
dc.creatorKrikelis, D.en
dc.creatorKotoula, V.en
dc.creatorMeiri, E.en
dc.creatorMalamou-Mitsi, Vassiliki D.en
dc.creatorFountzilas, Georgeen
dc.creatorSanden, M.en
dc.creatorPavlidis, Nicholasen
dc.creatorBenjamin, H.en
dc.creatorAharonov, R.en
dc.date.accessioned2018-06-22T09:54:25Z
dc.date.available2018-06-22T09:54:25Z
dc.date.issued2013
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/42349
dc.description.abstractNo data exist on biologic differences between Cancer of unknown primary (CUP) and metastatic solid tumors of known primary site. We assigned a primary tissue of origin in 40 favorable CUP patients (A: serous peritoneal carcinomatosis n = 14, B: axillary adenocarcinoma n = 8, C: upper squamous cervical adenopathy n = 18) by means of a 64-microRNA assay. Subsequently, we profiled the expression of 733 microRNAs (miRs) in the CUP cases and compared results with metastases from 20 ovarian carcinomas, 10 breast adenocarcinomas, 20 squamous head neck or lung tumors. In the Peritoneal CUP versus Ovarian (Known Primary Metastases) KPM comparison, a total of 12 miR were significantly differentially expressed: higher than twofold expression difference in CUP was seen only for miR-513a-5p (3.7-fold upregulated) and miR-483-5p (2.5-fold upregulated), while miR-708 exhibited a twofold downregulation. In the Breast CUP versus Breast KPM comparison, only miR-29c that were downregulated in CUP by 2.7-fold satisfied the FDR threshold. miR-30e and miR-27b, downregulated in ovarian CUPs versus KPMs, were also non-significantly downregulated in breast CUP by 2.0- and 1.4-fold respectively. Six miRs, which belong to the 17-92 oncocluster showed a trend of upregulation in Breast CUP versus Breast KPM cases. A CUP signature remains elusive. © 2012 Springer Science+Business Media Dordrecht.en
dc.language.isoengen
dc.sourceClinical and Experimental Metastasisen
dc.subjectArticleen
dc.subjectHumanen
dc.subjectNeoplasmsen
dc.subjectHumansen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectBreast neoplasmsen
dc.subjectFemaleen
dc.subjectMiddle ageden
dc.subjectOvarian neoplasmsen
dc.subjectRetrospective studiesen
dc.subjectRetrospective studyen
dc.subjectClinical articleen
dc.subjectPrognosisen
dc.subjectStatistical significanceen
dc.subjectLung neoplasmsen
dc.subjectNeoplasticen
dc.subjectCancer prognosisen
dc.subjectCarcinomaen
dc.subjectMaleen
dc.subjectProtein expressionen
dc.subjectFollow-up studiesen
dc.subjectGene expression regulationen
dc.subjectLymphatic metastasisen
dc.subjectUnclassified drugen
dc.subjectDown regulationen
dc.subjectUpregulationen
dc.subjectLung squamous cell carcinomaen
dc.subjectAdenocarcinomaen
dc.subjectSquamous cellen
dc.subjectBiologicalen
dc.subjectTumor markersen
dc.subjectCancer of unknown primary siteen
dc.subjectUnknown primaryen
dc.subjectComparative studyen
dc.subjectMicroarray analysisen
dc.subjectMicrorna 125a-5pen
dc.subjectCancer of unknown primaryen
dc.subjectHead and neck neoplasmsen
dc.subjectCarcinomatous peritonitisen
dc.subjectHead and neck squamous cell carcinomaen
dc.subjectNeoplasm gradingen
dc.subjectBreast adenocarcinomaen
dc.subjectOvary carcinomaen
dc.subjectMicrornasen
dc.subjectPrimary tumoren
dc.subjectPeritoneal neoplasmsen
dc.subjectGene expression profilingen
dc.subjectGene expressionen
dc.subjectCervical lymphadenopathyen
dc.subjectMicrornaen
dc.subjectMicrorna 106aen
dc.subjectMicrorna 143en
dc.subjectMicrorna 149en
dc.subjectMicrorna 17en
dc.subjectMicrorna 18aen
dc.subjectMicrorna 1972en
dc.subjectMicrorna 20aen
dc.subjectMicrorna 27ben
dc.subjectMicrorna 29cen
dc.subjectMicrorna 30een
dc.subjectMicrorna 331-3pen
dc.subjectMicrorna 483-5pen
dc.subjectMicrorna 513a-5pen
dc.subjectMicrorna 574-3pen
dc.subjectMicrorna 708en
dc.subjectMicrorna 92aen
dc.subjectMicrorna 92ben
dc.titleGlobal microRNA profiling in favorable prognosis subgroups of cancer of unknown primary (CUP) demonstrates no significant expression differences with metastases of matched known primary tumorsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1007/s10585-012-9548-3
dc.description.volume30
dc.description.issue4
dc.description.startingpage431
dc.description.endingpage439
dc.author.facultyΙατρική Σχολή / Medical School
dc.author.departmentΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen
dc.contributor.orcidPavlidis, Nicholas [0000-0002-2195-9961]
dc.contributor.orcidPentheroudakis, George [0000-0002-6632-2462]
dc.contributor.orcidKotoula, V. [0000-0002-8657-9732]
dc.gnosis.orcid0000-0002-2195-9961
dc.gnosis.orcid0000-0002-6632-2462
dc.gnosis.orcid0000-0002-8657-9732


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record