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Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
(2009)
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
(2013)
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
Scaling rules for diffusive drug delivery in tumor and normal tissues
(2011)
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse
(2013)
The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
(2012)
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
Multistage nanoparticles for improved delivery into tumor tissue
(2012)
The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...
Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
(2009)
Intravital multiphoton microscopy has provided powerful mechanistic insights into health and disease and has become a common instrument in the modern biological laboratory. The requisite high numerical aperture and exogenous ...