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Mathematical modeling of herpes simplex virus distribution in solid tumors: Implications for cancer gene therapy
(2009)
Purpose: Although oncolytic viral vectors show promise for the treatment of various cancers, ineffective initial distribution and propagation throughout the tumor mass often limit the therapeutic response. A mathematical ...
Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
(2013)
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan ...
Multistage nanoparticle delivery system for deep penetration into tumor tissue
(2011)
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided ...
Scaling rules for diffusive drug delivery in tumor and normal tissues
(2011)
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that ...
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
(2012)
The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic ...
Coevolution of solid stress and interstitial fluid pressure in tumors during progression: Implications for vascular collapse
(2013)
The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is ...
Combining two strategies to improve perfusion and drug delivery in solid tumors
(2013)
Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
(2012)
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress ...
Cationic nanoparticles have superior transvascular flux into solid tumors: Insights from a mathematical model
(2013)
Despite their great promise, only a few nanoparticle formulations have been approved for clinical use in oncology. The failure of nano-scale drugs to enhance cancer therapy is in large part due to inefficient delivery. To ...
Multistage nanoparticles for improved delivery into tumor tissue
(2012)
The enhanced permeability and retention (EPR) effect has been a key rationale for the development of nanoscale carriers to solid tumors. As a consequence of EPR, nanotherapeutics are expected to improve drug and detection ...