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Particle-Laden Flow in a Physiologically Realistic Human Airway Bifurcation
(Springer International Publishing, 2018)
Predicting regional deposition patterns of inhaled aerosols is important for the design and optimization of pharmaceutical formulations.
An efficient computational fluid-particle dynamics method to predict deposition in a simplified approximation of the deep lung
(2018)
High-fidelity simulations of the complete airway tree are still largely beyond current computational capabilities. Towards large-scale simulations of the human lung, the current study introduces a numerical methodology to ...
Targeted Drug Delivery to Upper Airways Using a Pulsed Aerosol Bolus and Inhaled Volume Tracking Method
(2019)
The pulmonary route presents an attractive delivery pathway for topical treatment of lung diseases. While significant progress has been achieved in understanding the physical underpinnings of aerosol deposition in the ...
Experimental methods for flow and aerosol measurements in human airways and their replicas
(2018)
Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant ...
Multiscale in silico lung modeling strategies for aerosol inhalation therapy and drug delivery
(2019)
Inhalation therapy is a hallmark of modern respiratory medicine. Over recent years, computational fluid-particle dynamics (CFPD) simulations of respiratory airflows and aerosol deposition in the lungs have rapidly developed ...
PIV measurements of the SimInhale benchmark case
(2019)
Particle Image Velocimetry (PIV) measurements with the aim of providing experimental data for the SimInhale benchmark case are presented within this work. We, therefore, present a refractive index matched, transparent model ...
The Effect of Flow Rate and Electrostatic Charge on Aerosol Deposition in a Realistic Lung Geometry
(Springer International Publishing, 2018)
To be able to predict the fate of therapeutic or pollutant xenobiotic inhaled particles in the human lungs, we need to understand the nature of airflow as it occurs throughout the entire respiratory tract.
Nanoparticles-enabled low temperature growth of carbon nanofibers and their properties for supercapa
(2018)
Nanoparticles-enabled low temperature growth of carbon nanofibers and their properties for supercapa
Targeting inhaled fibers to the pulmonary acinus: Opportunities for augmented delivery from in silico simulations
(2019)
Non-spherical particles, and fibers in particular, are potentially attractive airborne carriers for pulmonary drug delivery. Not only do they exhibit a high surface-to-volume ratio relative to spherical aerosols, but their ...
In silico assessment of mouth-throat effects on regional deposition in the upper tracheobronchial airways
(2018)
Regional deposition of inhaled medicines is a valuable metric of effectiveness in drug delivery applications to the lung. In silico methods are now emerging as a valuable tool for the detailed description of localized ...