Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering: Recent submissions
Now showing items 21-40 of 1036
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Article
A quantitative in silico platform for simulating cytotoxic and nanoparticle drug delivery to solid tumours
(2019)The role of tumour–host mechano-biology and the mechanisms involved in the delivery of anti-cancer drugs have been extensively studied using in vitro and in vivo models. A complementary approach is offered by in silico ...
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Article
On the kinetics of reconfigurable hybrid structures
(2018)The paper refers to a basic reconfigurable structural typology of hinge-connected members forming of an n-bar planar linkage and a secondary system of struts and cables. The system aims at providing both structural stability ...
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Article
Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside
(2018)Physical forces have a crucial role in tumor progression and cancer treatment. The application of principles of engineering and physical sciences to oncology has provided powerful insights into the mechanisms by which these ...
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Article
Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis
(2018)Metastasis is a multistep process in which tumor extracellular matrix (ECM) and cancer cell cytoskeleton interactions are pivotal. ECM is connected, through integrins, to the cell's adhesome at cell-ECM adhesion sites and ...
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Article
Radiation-induced fibrosis in breast cancer: A protocol for an observational cross-sectional pilot study for personalised risk estimation and objective assessment
(2019)Introduction: About 30% of patients request breast reconstruction following surgery for breast cancer, but radiation therapy negatively influences the outcome. Post-reconstruction radiotherapy is associated with more ...
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Article
Solid Stress Facilitates Fibroblasts Activation to Promote Pancreatic Cancer Cell Migration
(2018)Pancreatic fibroblasts are continuously gaining ground as an important component of tumor microenvironment that dynamically interact with cancer cells to promote tumor progression. In addition, these tumor-infiltrated ...
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Article
Defining the Role of Solid Stress and Matrix Stiffness in Cancer Cell Proliferation and Metastasis
(2018)Solid tumors are characterized by an abnormal stroma that contributes to the development of biomechanical abnormalities in the tumor microenvironment. In particular, these abnormalities include an increase in matrix stiffness ...
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Article
A Platform Integrating Acquisition, Reconstruction, Visualization, and Manipulator Control Modules for MRI-Guided Interventions
(2019)This work presents a platform that integrates a customized MRI data acquisition scheme with reconstruction and three-dimensional (3D) visualization modules along with a module for controlling an MRI-compatible robotic ...
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Article
Reconfigurable Modular Bar Structure
(2019)Structural modularity and reconfiguration allow for enhanced flexibility and adaptability to changing functional, environmental or loading conditions, contributing thus to a sustainable built up environment. The current ...
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Article
Development of the post-form strength prediction model for a high-strength 6xxx aluminium alloy with pre-existing precipitates and residual dislocations
(2019)The applications of lightweight and high strength sheet aluminium alloys are increasing rapidly in the automotive industry due to the expanding global demand in this industrial cluster. Accurate prediction of the post-form ...
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Article
A device for high-throughput monitoring of degradation in soft tissue samples
(2018)This work describes the design and validation of a novel device, the High-Throughput Degradation Monitoring Device (HDD), for monitoring the degradation of 24 soft tissue samples over incubation periods of several days ...
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Article
Direct Laser Printing of Liver Cells on Porous Collagen Scaffolds
(2018)Over the past years, direct printing techniques have been increasingly utilized in biomedical research applications including the fabrication of biosensors by printing biomaterials on electronic devices [1] and the fabrication ...
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Article
Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales
(2018)This article is a review of current research on the mechanism of regeneration of skin and peripheral nerves based on use of collagen scaffolds, particularly the dermis regeneration template (DRT), which is widely used ...
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Book Chapter
Mri-guided robotic breast biopsy and therapeutics
(World Scientific Publishing Company, 2018)Breast magnetic resonance imaging (MRI) has been shown to be a very sensitive method for the detection of breast cancer, offers a plethora of contrast mechanisms, high image quality and has no ionizing radiation. Fueled ...
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Article
Experimental implementation of the ‘effective 4-bar method’ on a reconfigurable articulated structure
(2019)A structural concept for reconfigurable buildings is considered. Its basic element is the planar n-bar linkage whose joints are equipped with brakes. Stepwise reconfigurations are realized based on the ‘effective 4-bar’ ...
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Article
Effect of porosities on tensile properties of laser-welded Al-Li alloy: an experimental and modelling study
(2018)Aluminium–lithium (Al-Li) alloys are very attractive for aerospace applications due to their outstanding properties, such as high specific strength, high rigidity and good resistance to corrosion and fatigue, compared to ...
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Article
Formability and microstructure evolution mechanisms of Ti6Al4V alloy during a novel hot stamping process
(2018)A novel hot stamping process for Ti6Al4V alloy using cold forming tools and a hot blank was presented in this paper. The formability of the material was studied through uniaxial tensile tests at temperatures ranging from ...
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Article
A review on forming techniques for manufacturing lightweight complex—shaped aluminium panel components
(2018)Aluminium alloys are being increasingly utilised in the automotive and aerospace industries to reduce the weight of vehicles. Extensive research has been conducted to overcome the poor ductility of aluminium alloys at room ...
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Article
A review of force reduction methods in precision forging axisymmetric shapes
(2018)This paper provides a review of the methods developed over the years for reducing working forces for the precision metal forming processes. Precision forging normally involves completely, or near completely closed cavity ...
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Article
Development of an interactive friction model to predict aluminum transfer in a pin-on-disc sliding system
(2019)In aluminum forming processes, it is observed that the coefficient of friction increases and a transfer layer is formed on the tool surfaces. In the current paper, this phenomenon is studied via pin-on-disc dry sliding ...