Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering: Recent submissions

Now showing items 301-320 of 1036

    • Conference Object  

      Design rules for cancer nanomedicines 

      Stylianopoulos, T.; Soteriou, K.; Fukumura, D.; Jain, R. K. (Affiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusAffiliation: Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United StatesCorrespondence Address: Stylianopoulos, T.Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, Cyprus, 2012)
      The use of nanotechnology has offered new hope for cancer detection, prevention and treatment. Nanoparticle formulations are advantageous over conventional chemotherapy because they can incorporate multiple diagnostic and ...
    • Article  

      Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy 

      Stylianopoulos, T.; Munn, L. L.; Jain, R. K. (2018)
      [Figure presented] A solid tumor is like an aberrant organ – comprised of cancer cells and a variety of host cells embedded in an extracellular matrix – nourished by blood vessels and drained by lymphatic vessels. In its ...
    • Conference Object  

      Residual stresses in solid tumors: Implications to tumor growth and drug delivery 

      Stylianopoulos, T.; Martin, J. D.; Chauhan, V. P.; Munn, L. L.; Jain, R. K. (Affiliation: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United StatesAffiliation: Department of Mechanical and Manufacturing Engineering, University of Cyprus, Nicosia, CyprusCorrespondence Address: Edwin L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, United States, 2012)
    • Article  

      Computational predictions of the tensile properties of electrospun fibre meshes: Effect of fibre diameter and fibre orientation 

      Barocas, V. Η; Stylianopoulos, T.; Bashur, C. A.; Goldstein, A. S.; Guelcher, S. A. (2008)
      The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, ...
    • Article  

      Diffusion anisotropy in collagen gels and tumors: The effect of fiber network orientation 

      Stylianopoulos, T.; Diop-Frimpong, B.; Munn, L. L.; Jain, R. K. (2010)
      The interstitial matrix is comprised of cross-linked collagen fibers, generally arranged in nonisotropic orientations. Spatial alignment of matrix components within the tissue can affect diffusion patterns of drugs. In ...
    • Conference Object  

      Modeling of collagen gels: A microstructural approach 

      Barocas, V. Η; Stylianopoulos, T. (Affiliation: Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, United States, 2005)
    • Article  

      Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors 

      Stylianopoulos, T.; Economides, E. A.; Baish, J. W.; Fukumura, D.; Jain, R. K. (2015)
      Conventional drug delivery systems for solid tumors are composed of a nano-carrier that releases its therapeutic load. These two-stage nanoparticles utilize the enhanced permeability and retention (EPR) effect to enable ...
    • Article  

      Combining two strategies to improve perfusion and drug delivery in solid tumors 

      Stylianopoulos, T.; Jain, R. K. (2013)
      Blood perfusion in tumors can be significantly lower than that in the surrounding normal tissue owing to the leakiness and/or compression of tumor blood vessels. Impaired perfusion reduces oxygen supply and results in a ...
    • Article  

      Design considerations for nanotherapeutics in oncology 

      Stylianopoulos, T.; Jain, R. K. (2015)
      Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the ...
    • Article  

      Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes. 

      Stylianopoulos, T.; Kokonou, M.; Michael, S.; Tryfonos, A.; Rebholz, Claus; Odysseos, A. D.; Doumanidis, C. C. (2012)
      The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, ...
    • Conference Object  

      Multiscale, adaptive finite element computations for soft tissue biomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Luo, X.; Shephard, M. S. (Affiliation: Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Scientific Computation Research Center (SCOREC), Rensselaer Polytechnic Institute, Troy, NY 12180, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2007)
    • Article  

      The Solid Mechanics of Cancer and Strategies for Improved Therapy 

      Stylianopoulos, T. (2017)
      Tumor progression and response to treatment is determined in large part by the generation of mechanical stresses that stem from both the solid and the fluid phase of the tumor. Furthermore, elevated solid stress levels can ...
    • Article  

      EPR-effect: Utilizing size-dependent nanoparticle delivery to solid tumors 

      Stylianopoulos, T. (2013)
    • Article  

      Volume-averaging theory for the study of the mechanics of collagen networks 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      A multiscale methodology has been developed for modeling mechanical behavior of collagen fiber networks. The methodology addresses scale separation between the macroscopic, tissue-level scale and the microscopic, fiber-level ...
    • Article  

      Constraints on the temperature dependence of the magnetic penetration depth of superconducting Bi2Sr2CaCu2O8+x from measurements of the low-temperature specific heat 

      Stupp, S. E.; Lee, W. C.; Giapintzakis, John; Ginsberg, D. M. (1992)
      We have measured the low-temperature (2"10 K) specific heat of polycrystalline Bi2Sr2CaCu2O8+x in zero applied field and in an applied magnetic field of 1 T. We find no field-induced enhancement of the specific heat, to ...
    • Article  

      Multiscale, structure-based modeling for the elastic mechanical behavior of arterial walls 

      Barocas, V. Η; Stylianopoulos, T. (2007)
      Passive elastic behavior of arterial wall remains difficult to model. Although phenomenological and structural models exist, the question of how the three-dimensional network structure of the collagen in the artery determines ...
    • Article  

      Intelligent drug delivery systems for the treatment of solid tumors 

      Stylianopoulos, T. (2016)
      The rationale for the use of nanoparticle formulations to treat cancer is based on the ability of these particles to facilitate selective delivery of drugs to the tumor site, reducing adverse effects and improving therapeutic ...
    • Article  

      A structural, kinetic model of soft tissue thermomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Aksan, A. (2008)
      A structure-based kinetic model was developed to predict the thermomechanical response of collagenous soft tissues. The collagen fibril was represented as an ensemble of molecular arrays with cross-links connecting the ...
    • Article  

      Symmetry of differential optical responses of normal and superconducting phases in single-crystal YBCO 

      Studenmund, W. R.; Fishman, I. M.; Kino, G. S.; Giapintzakis, John (1995)
      We measured differential optical reflectivity (DOR) of YBCO single domains. DOR measurements reject the temperature independent bulk reflectivity and reveal dR dT. These measurements detect the superconducting transition, ...
    • Conference Object  

      A structural, kinetic model of soft tissue thermomechanics 

      Barocas, V. Η; Stylianopoulos, T.; Aksan, A. (Affiliation: Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesAffiliation: Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, United StatesCorrespondence Address: Stylianopoulos, T.Department of Chemical Engineering, University of Minnesota, Minneapolis, MN 55455, United States, 2007)