Show simple item record

dc.contributor.authorChauhan, V. P.en
dc.contributor.authorStylianopoulos, T.en
dc.contributor.authorMartin, J. D.en
dc.contributor.authorPopoviÄ, Z.en
dc.contributor.authorChen, O.en
dc.contributor.authorKamoun, W. S.en
dc.contributor.authorBawendi, M. G.en
dc.contributor.authorFukumura, D.en
dc.contributor.authorJain, R. K.en
dc.creatorChauhan, V. P.en
dc.creatorStylianopoulos, T.en
dc.creatorMartin, J. D.en
dc.creatorPopoviÄ, Z.en
dc.creatorChen, O.en
dc.creatorKamoun, W. S.en
dc.creatorBawendi, M. G.en
dc.creatorFukumura, D.en
dc.creatorJain, R. K.en
dc.date.accessioned2019-05-06T12:23:28Z
dc.date.available2019-05-06T12:23:28Z
dc.date.issued2012
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48289
dc.description.abstractThe blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapiesĝwhich ĝ̃ normalizeĝ™ the abnormal blood vessels in tumours by making them less leakyĝhave been shown to improve the delivery and effectiveness of chemotherapeutics with low molecular weights, but it remains unclear whether normalizing tumour vessels can improve the delivery of nanomedicines. Here, we show that repairing the abnormal vessels in mammary tumours, by blocking vascular endothelial growth factor receptor-2, improves the delivery of smaller nanoparticles (diameter, 12 nm) while hindering the delivery of larger nanoparticles (diameter, 125 nm). Using a mathematical model, we show that reducing the sizes of pores in the walls of vessels through normalization decreases the interstitial fluid pressure in tumours, thus allowing small nanoparticles to enter them more rapidly. However, increased steric and hydrodynamic hindrances, also associated with smaller pores, make it more difficult for large nanoparticles to enter tumours. Our results further suggest that smaller (1/412 nm) nanomedicines are ideal for cancer therapy due to their superior tumour penetration. © 2012 Macmillan Publishers Limited.en
dc.language.isoengen
dc.sourceNature Nanotechnologyen
dc.subjectarticleen
dc.subjectmathematical modelen
dc.subjectantineoplastic agenten
dc.subjectdoxorubicinen
dc.subjectcontrolled studyen
dc.subjectcancer combination chemotherapyen
dc.subjectpaclitaxelen
dc.subjectpriority journalen
dc.subjectdrug efficacyen
dc.subjectnonhumanen
dc.subjecttumor vascularizationen
dc.subjectcancer therapyen
dc.subjectanimal experimenten
dc.subjectanimal modelen
dc.subjectmouseen
dc.subjectmolecular weighten
dc.subjectbreast tumoren
dc.subjectvasculotropin receptor 2en
dc.subjectdrug delivery systemen
dc.subjectparticle sizeen
dc.subjecttissue pressureen
dc.subjectantiangiogenic therapyen
dc.subjectblood vessel wallen
dc.subjecthydrodynamicsen
dc.subjectmonoclonal antibody DC101en
dc.subjectnanomedicineen
dc.subjectnanoparticleen
dc.subjectporosityen
dc.subjectpressure gradienten
dc.subjectstereospecificityen
dc.titleNormalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manneren
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/nnano.2012.45
dc.description.volume7
dc.description.startingpage383
dc.description.endingpage388
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages383-388


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record