dc.contributor.author | Lizal, F. | en |
dc.contributor.author | Jedelsky, J. | en |
dc.contributor.author | Morgan, K. | en |
dc.contributor.author | Bauer, K. | en |
dc.contributor.author | Llop, J. | en |
dc.contributor.author | Cossio, U. | en |
dc.contributor.author | Kassinos, Stavros C. | en |
dc.contributor.author | Verbanck, S. | en |
dc.contributor.author | Ruiz-Cabello, J. | en |
dc.contributor.author | Santos, A. | en |
dc.contributor.author | Koch, E. | en |
dc.contributor.author | Schnabel, C. | en |
dc.creator | Lizal, F. | en |
dc.creator | Jedelsky, J. | en |
dc.creator | Morgan, K. | en |
dc.creator | Bauer, K. | en |
dc.creator | Llop, J. | en |
dc.creator | Cossio, U. | en |
dc.creator | Kassinos, Stavros C. | en |
dc.creator | Verbanck, S. | en |
dc.creator | Ruiz-Cabello, J. | en |
dc.creator | Santos, A. | en |
dc.creator | Koch, E. | en |
dc.creator | Schnabel, C. | en |
dc.date.accessioned | 2019-05-06T12:24:04Z | |
dc.date.available | 2019-05-06T12:24:04Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48584 | |
dc.description.abstract | Recent developments in the prediction of local aerosol deposition in human lungs are driven by the fast development of computational simulations. Although such simulations provide results in unbeatable resolution, significant differences among distinct methods of calculation emphasize the need for highly precise experimental data in order to specify boundary conditions and for validation purposes. This paper reviews and critically evaluates available methods for the measurement of single and disperse two-phase flows for the study of respiratory airflow and deposition of inhaled particles, performed both in vivo and in replicas of airways. Limitations and possibilities associated with the experimental methods are discussed and aspects of the computational calculations that can be validated are indicated. The review classifies the methods into following categories: 1) point-wise and planar methods for velocimetry in the airways, 2) classic methods for the measurement of the regional distribution of inhaled particles, 3) standard medical imaging methods applicable to the measurement of the regional aerosol distribution and 4) emerging and nonconventional methods. All methods are described, applications in human airways studies are illustrated, and recommendations for the most useful applications of each method are given. © 2017 Elsevier B.V. | en |
dc.language.iso | eng | en |
dc.source | European Journal of Pharmaceutical Sciences | en |
dc.subject | human | en |
dc.subject | priority journal | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | Article | en |
dc.subject | positron emission tomography | en |
dc.subject | microscopy | en |
dc.subject | diagnostic imaging | en |
dc.subject | radioisotope | en |
dc.subject | particle size | en |
dc.subject | dispersion | en |
dc.subject | aerosol | en |
dc.subject | airway | en |
dc.subject | Computational fluid particle dynamics | en |
dc.subject | particle image velocimetry | en |
dc.subject | exhalation | en |
dc.subject | inhalation | en |
dc.subject | anemometry | en |
dc.subject | respiratory airflow | en |
dc.subject | Aerosol deposition | en |
dc.subject | CFD validation | en |
dc.subject | Experimental methods | en |
dc.subject | flow measurement | en |
dc.subject | Flow measurement techniques | en |
dc.subject | fluorometry | en |
dc.subject | Gas–liquid two-phase flow | en |
dc.subject | gravimetry | en |
dc.subject | Human airways | en |
dc.subject | lung deposit | en |
dc.subject | Lungs | en |
dc.subject | measurement precision | en |
dc.subject | Medical imaging | en |
dc.subject | optical coherence tomography | en |
dc.subject | single photon emission computed tomography | en |
dc.subject | tracer | en |
dc.subject | Velocimetry techniques | en |
dc.subject | volumetry | en |
dc.title | Experimental methods for flow and aerosol measurements in human airways and their replicas | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.ejps.2017.08.021 | |
dc.description.volume | 113 | |
dc.description.startingpage | 95 | |
dc.description.endingpage | 131 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Kassinos, Stavros C. [0000-0002-3501-3851] | |
dc.description.totalnumpages | 95-131 | |
dc.gnosis.orcid | 0000-0002-3501-3851 | |