dc.contributor.author | Barocas, V. Η | el |
dc.contributor.author | Stylianopoulos, T. | en |
dc.contributor.author | Aksan, A. | en |
dc.creator | Barocas, V. Η | el |
dc.creator | Stylianopoulos, T. | en |
dc.creator | Aksan, A. | en |
dc.date.accessioned | 2019-05-06T12:24:39Z | |
dc.date.available | 2019-05-06T12:24:39Z | |
dc.date.issued | 2008 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/48850 | |
dc.description.abstract | A structure-based kinetic model was developed to predict the thermomechanical response of collagenous soft tissues. The collagen fibril was represented as an ensemble of molecular arrays with cross-links connecting the collagen molecules within the same array. A two-state kinetic model for protein folding was employed to represent the native and the denatured states of the collagen molecule. The Monte Carlo method was used to determine the state of the collagen molecule when subjected to thermal and mechanical loads. The model predictions were compared to existing experimental data for New Zealand white rabbit patellar tendons. The model predictions for one-dimensional tissue shrinkage and the corresponding mechanical property degradation agreed well with the experimental data, showing that the gross tissue behavior is dictated by molecular-level phenomena. © 2008 by the Biophysical Society. | en |
dc.language.iso | eng | en |
dc.source | Biophysical journal | en |
dc.subject | article | en |
dc.subject | prediction | en |
dc.subject | nonhuman | en |
dc.subject | animal experiment | en |
dc.subject | kinetics | en |
dc.subject | Monte Carlo method | en |
dc.subject | soft tissue | en |
dc.subject | structure analysis | en |
dc.subject | thermal analysis | en |
dc.subject | mechanics | en |
dc.subject | thermodynamics | en |
dc.subject | degradation | en |
dc.subject | protein folding | en |
dc.subject | collagen fibril | en |
dc.subject | cross linking | en |
dc.subject | molecule | en |
dc.subject | Oryctolagus cuniculus | en |
dc.subject | patella tendon | en |
dc.subject | rabbit | en |
dc.title | A structural, kinetic model of soft tissue thermomechanics | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1529/biophysj.107.111716 | |
dc.description.volume | 94 | |
dc.description.startingpage | 717 | |
dc.description.endingpage | 725 | |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Stylianopoulos, T. [0000-0002-3093-1696] | |
dc.description.totalnumpages | 717-725 | |
dc.gnosis.orcid | 0000-0002-3093-1696 | |