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dc.contributor.authorBarocas, V. Ηel
dc.contributor.authorStylianopoulos, T.en
dc.contributor.authorAksan, A.en
dc.creatorBarocas, V. Ηel
dc.creatorStylianopoulos, T.en
dc.creatorAksan, A.en
dc.date.accessioned2019-05-06T12:24:39Z
dc.date.available2019-05-06T12:24:39Z
dc.date.issued2008
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/48850
dc.description.abstractA structure-based kinetic model was developed to predict the thermomechanical response of collagenous soft tissues. The collagen fibril was represented as an ensemble of molecular arrays with cross-links connecting the collagen molecules within the same array. A two-state kinetic model for protein folding was employed to represent the native and the denatured states of the collagen molecule. The Monte Carlo method was used to determine the state of the collagen molecule when subjected to thermal and mechanical loads. The model predictions were compared to existing experimental data for New Zealand white rabbit patellar tendons. The model predictions for one-dimensional tissue shrinkage and the corresponding mechanical property degradation agreed well with the experimental data, showing that the gross tissue behavior is dictated by molecular-level phenomena. © 2008 by the Biophysical Society.en
dc.language.isoengen
dc.sourceBiophysical journalen
dc.subjectarticleen
dc.subjectpredictionen
dc.subjectnonhumanen
dc.subjectanimal experimenten
dc.subjectkineticsen
dc.subjectMonte Carlo methoden
dc.subjectsoft tissueen
dc.subjectstructure analysisen
dc.subjectthermal analysisen
dc.subjectmechanicsen
dc.subjectthermodynamicsen
dc.subjectdegradationen
dc.subjectprotein foldingen
dc.subjectcollagen fibrilen
dc.subjectcross linkingen
dc.subjectmoleculeen
dc.subjectOryctolagus cuniculusen
dc.subjectpatella tendonen
dc.subjectrabbiten
dc.titleA structural, kinetic model of soft tissue thermomechanicsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1529/biophysj.107.111716
dc.description.volume94
dc.description.startingpage717
dc.description.endingpage725
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής / Department of Mechanical and Manufacturing Engineering
dc.type.uhtypeArticleen
dc.contributor.orcidStylianopoulos, T. [0000-0002-3093-1696]
dc.description.totalnumpages717-725
dc.gnosis.orcid0000-0002-3093-1696


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