Show simple item record

dc.contributor.authorDemetriou, Victoria L.en
dc.contributor.authorKyriakou, Eftychiaen
dc.contributor.authorKostrikis, Leontios G.en
dc.creatorDemetriou, Victoria L.en
dc.creatorKyriakou, Eftychiaen
dc.creatorKostrikis, Leontios G.en
dc.description.abstractFew natural intergenotypic hepatitis C virus (HCV) recombinants have been characterised, and only RF1-2k/1b has demonstrated widespread transmission. The near-full length genome sequences for two cases of 2k/1b recombinants (CYHCV037 and CYHCV093) sampled in Cyprus were obtained using strain-specific RT-PCR amplification and sequencing protocols. Sequence analysis confirmed their similarity with the original RF1-2k/1b strain from St. Petersburg, N687. These two isolates significantly contribute to the sequence data available on this recombinant and confirm its increasing spread among individuals from Eastern Europe, and its association with transmission through intravenous drug use. Phylogenetic analyses reveal clustering of the sequence 3′ to the recombination point, not seen in the topology of the 5′ sequences, implying a more complicated evolutionary history than that held to date. The increasing cases of HCV recombinant strains underline the requirement of their contribution to the standardised rules of HCV classification and nomenclature, molecular epidemiology, diagnosis, and treatment. © 2011 Victoria L. Demetriou et al.en
dc.sourceAdvances in Virologyen
dc.subjectHepatitis C virusen
dc.titleNear-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis c virus isolatesen
dc.description.volume2011Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied SciencesΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.description.notes<p>Cited By :9</p>en
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record