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dc.contributor.authorPromponas, Vasilis J.en
dc.contributor.authorKatsani, K. R.en
dc.contributor.authorBlencowe, B. J.en
dc.contributor.authorOuzounis, Christos A.en
dc.date.accessioned2019-11-04T12:52:33Z
dc.date.available2019-11-04T12:52:33Z
dc.date.issued2016
dc.identifier.issn2045-2322
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53332
dc.description.abstractEukaryotic cells are defined by compartments through which the trafficking of macromolecules is mediated by large complexes, such as the nuclear pore, transport vesicles and intraflagellar transport. The assembly and maintenance of these complexes is facilitated by endomembrane coatomers, long suspected to be divergently related on the basis of structural and more recently phylogenomic analysis. By performing supervised walks in sequence space across coatomer superfamilies, we uncover subtle sequence patterns that have remained elusive to date, ultimately unifying eukaryotic coatomers by divergent evolution. The conserved residues shared by 3,502 endomembrane coatomer components are mapped onto the solenoid superhelix of nucleoporin and COPII protein structures, thus determining the invariant elements of coatomer architecture. This ancient structural motif can be considered as a universal signature connecting eukaryotic coatomers involved in multiple cellular processes across cell physiology and human disease.en
dc.sourceScientific Reportsen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84960193493&doi=10.1038%2fsrep22311&partnerID=40&md5=60c1a03cd3043961820bd12cb18d9abb
dc.subjectamino acid sequenceen
dc.subjectmetabolismen
dc.subjectchemistryen
dc.subjectcell membraneen
dc.subjectEukaryotaen
dc.subjectEvolution, Molecularen
dc.subjecteukaryoteen
dc.subjectmolecular modelen
dc.subjectmolecular evolutionen
dc.subjectModels, Molecularen
dc.subjectcoatomer proteinen
dc.subjectconserved sequenceen
dc.subjectCOP-coated vesicleen
dc.subjectCOP-Coated Vesiclesen
dc.titleSequence evidence for common ancestry of eukaryotic endomembrane coatomersen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/srep22311
dc.description.volume6
dc.type.uhtypeArticleen
dc.source.abbreviationSci.Rep.en
dc.contributor.orcidPromponas, Vasilis J. [0000-0003-3352-4831]


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