dc.contributor.author | Kalogirou, Andreas S. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Kalogirou, Andreas S. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:19:41Z | |
dc.date.available | 2019-11-21T06:19:41Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55625 | |
dc.description.abstract | Palladium catalyzed direct C-H arylation of 3-bromoisothiazole-5-carbonitrile with aryl/hetaryl iodides in the presence of AgF gave 13 4-aryl/hetaryl-3-bromoisothiazole-5-carbonitriles. The scope of this arylation was investigated and explanations for the limitations proposed. 3-Bromoisothiazole-5-carboxamide was isolated as a side-product, and its formation was attributed to Ag+-catalyzed hydration of the C-5 nitrile. The analogous phenylation of 3-chloroisothiazole-5-carbonitrile and 3-bromoisothiazole-4-carboxamide gave 3-chloro-4-phenylisothiazole-5-carbonitrile and 3-bromo-5-phenylisothiazole-4-carboxamide in 83 and 64% yields, respectively. © 2014 Elsevier B.V. All rights reserved. | en |
dc.source | Tetrahedron | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84906965116&doi=10.1016%2fj.tet.2014.07.064&partnerID=40&md5=170d32d2b30391fa8a2451ed6d15f56a | |
dc.subject | unclassified drug | en |
dc.subject | Article | en |
dc.subject | hydration | en |
dc.subject | covalent bond | en |
dc.subject | synthesis | en |
dc.subject | chemical modification | en |
dc.subject | arylation | en |
dc.subject | silver | en |
dc.subject | 3 bromoisothiazole 5 carbonitrile | en |
dc.subject | cyanide | en |
dc.subject | Isothiazoles Heteroarenes Sulfur-nitrogen heterocycles C-H arylation Palladium | en |
dc.subject | phenylation | en |
dc.title | Silver mediated direct C-H arylation of 3-bromoisothiazole-5-carbonitrile | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tet.2014.07.064 | |
dc.description.issue | 38 | |
dc.description.startingpage | 6796 | |
dc.description.endingpage | 6802 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :1</p> | en |
dc.source.abbreviation | Tetrahedron | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.contributor.orcid | Kalogirou, Andreas S. [0000-0002-5476-5805] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |
dc.gnosis.orcid | 0000-0002-5476-5805 | |