Show simple item record

dc.contributor.authorKoutentis, Panayiotis Andreasen
dc.contributor.authorLoizou, G.en
dc.contributor.authorLo Re, D.en
dc.creatorKoutentis, Panayiotis Andreasen
dc.creatorLoizou, G.en
dc.creatorLo Re, D.en
dc.date.accessioned2019-11-21T06:20:33Z
dc.date.available2019-11-21T06:20:33Z
dc.date.issued2011
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55727
dc.description.abstractSilver(I) fluoride (AgF)-mediated intramolecular nonoxidative and oxidative palladium-catalyzed cyclizations of 1,3-diphenyl- and 8-iodo-1,3- diphenylbenzo[e][1,2,4]triazin-7(1H)-ones 6a (R = H) and 7a (R = I) afford a new 'alkaloid like' ring system 2-phenyl-6H-[1,2,4]triazino[5,6,1-jk]carbazol-6-one 8a (triazafluoranthenone) in 86 and 100% yields, respectively. Furthermore, these cyclization protocols were used to prepare triazafluoranthenone analogues 8b - e bearing dialkylamino, methoxy, and phenylsulfanyl substituents at C-5, which were also independently synthesized from triazafluoranthenone 8a by regioselective nucleophilic addition. Similar AgF-mediated intramolecular nonoxidative and oxidative palladium-catalyzed cyclizations of 8,10-dihydro-1-iodo-10-phenylphenazin-2(7H)-ones 13 gave the new 'alkaloid like' ring system 8H-indolo[1,2,3-mn]phenazin-8-one 14 in 80 and 18% yields, respectively. © 2011 American Chemical Society.en
dc.sourceJournal of Organic Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79960204366&doi=10.1021%2fjo200966k&partnerID=40&md5=406c1416ea2db06915bc300eb4d2577b
dc.subjectarticleen
dc.subjectunclassified drugen
dc.subjectsynthesisen
dc.subjectOxidation-Reductionen
dc.subjectCatalysisen
dc.subjectcross linkingen
dc.subjectpalladiumen
dc.subjectMolecular Structureen
dc.subjectOrganometallic Compoundsen
dc.subjectoxidation reduction potentialen
dc.subjectdrug structureen
dc.subjectStereoisomerismen
dc.subjectNitrogen compoundsen
dc.subjectnucleophilicityen
dc.subjectAddition reactionsen
dc.subjectsilveren
dc.subjectFluoridesen
dc.subjectSilver Compoundsen
dc.subjectCyclizationen
dc.subjectRegioselective nucleophilic additionen
dc.subjectRing systemsen
dc.subject2 phenyl 5 (phenylthio) 6h[1,2,4]triazino[ 5,6,1 jk]carbazol 6 oneen
dc.subject2 phenyl 5 (pyrrolidin 1 yl) 6h[1,2,4]triazino[ 5,6,1 jk]carbazol 6 oneen
dc.subject5 (diethylamino) 2 phenyl 6h[1,2,4]triazino[ 5,6,1 jk]carbazol 6 oneen
dc.subject5 methoxy 2 phenyl 6h[1,2,4]triazino[5,6,1 jk]carbazol 6 oneen
dc.subject8,10 dihydro 1 iodo 10 phenylphenazin 2(7h)oneen
dc.subjectAza Compoundsen
dc.subjectCyclizationsen
dc.subjectfluorantheneen
dc.subjectMetabolitesen
dc.subjectMethoxyen
dc.subjectNon-oxidativeen
dc.subjectSilver halidesen
dc.titleSynthesis of triazafluoranthenones via silver(I)-mediated nonoxidative and oxidative intramolecular palladium-catalyzed cyclizationsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1021/jo200966k
dc.description.volume76
dc.description.issue14
dc.description.startingpage5793
dc.description.endingpage5802
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Χημείας / Department of Chemistry
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :16</p>en
dc.source.abbreviationJ.Org.Chem.en
dc.contributor.orcidKoutentis, Panayiotis Andreas [0000-0002-4652-7567]
dc.gnosis.orcid0000-0002-4652-7567


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record