dc.contributor.author | Michaelidou, Sophia S. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Michaelidou, Sophia S. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:21:27Z | |
dc.date.available | 2019-11-21T06:21:27Z | |
dc.date.issued | 2010 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55850 | |
dc.description.abstract | Anthranilonitrile 3a, 4,5-dimethoxyanthranilonitrile 3b and 5-nitroanthranilonitrile 3c, react with paraformaldehyde, KCN and ZnCl2 in acetic acid under acid catalysis (H2SO4) in a sealed tube at ca. 55 °C to give the corresponding 2-(cyanomethylamino)benzonitriles 4a-c in 96, 86 and 57% yields, respectively. Thorpe-Ziegler cyclisation of the N-unprotected 2-(cyanomethylamino)benzonitriles 4a-c with K2CO3 in EtOH at elevated temperatures and pressures using either microwave heating or conventional heating in a sealed tube gives 3-amino, 3-amino-5,6-dimethoxy, and 3-amino-5-nitroindole-2-carbonitriles 2a-c in moderate to good yields. All new compounds are fully characterised. © 2009 Elsevier Ltd. All rights reserved. | en |
dc.source | Tetrahedron | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-71649096942&doi=10.1016%2fj.tet.2009.11.067&partnerID=40&md5=cfc49a2e77b9cc1f61f025faa9e07d52 | |
dc.subject | article | en |
dc.subject | priority journal | en |
dc.subject | microwave radiation | en |
dc.subject | nitrile | en |
dc.subject | pressure | en |
dc.subject | chemical reaction | en |
dc.subject | catalysis | en |
dc.subject | indole derivative | en |
dc.subject | cyclization | en |
dc.subject | acetic acid | en |
dc.subject | alcohol | en |
dc.subject | high temperature | en |
dc.subject | benzonitrile | en |
dc.subject | paraformaldehyde | en |
dc.subject | potassium carbonate | en |
dc.subject | potassium cyanide | en |
dc.subject | zinc chloride | en |
dc.title | Microwave assisted synthesis of 3-aminoindole-2-carbonitriles from anthranilonitriles via N-unprotected 2-(cyanomethylamino)benzonitriles | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.tet.2009.11.067 | |
dc.description.volume | 66 | |
dc.description.issue | 3 | |
dc.description.startingpage | 685 | |
dc.description.endingpage | 688 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :11</p> | en |
dc.source.abbreviation | Tetrahedron | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |