dc.contributor.author | Michaelidou, Sophia S. | en |
dc.contributor.author | Koutentis, Panayiotis Andreas | en |
dc.creator | Michaelidou, Sophia S. | en |
dc.creator | Koutentis, Panayiotis Andreas | en |
dc.date.accessioned | 2019-11-21T06:21:27Z | |
dc.date.available | 2019-11-21T06:21:27Z | |
dc.date.issued | 2009 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/55851 | |
dc.description.abstract | A series of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino) benzonitriles were prepared from the reaction of 4,5-dichloro-1,2,3-dithiazolium chloride (Appel salt) and the corresponding anthranilonitriles. Reaction of the 1,2,3-dithiazolimines with DBU (3 equiv) at -5 °C gave the corresponding 2-cyano-cyanothioformanilides in near quantitative yields. Treatment of 2-(4-chloro-5H-1,2,3-dithiazol-5-ylideneamino)benzonitrile with DBU (4 equiv) at -5 to +20 °C gave 2-isothiocyanatobenzonitrile in 96% yield. The latter compound was also formed directly from 2-cyano-cyanothioformanilide on treatment with DBU (1 equiv) in 95% yield. A tentative mechanism for the DBU-mediated dithiazole to cyanothioformanilide transformation is proposed and all compounds were fully characterized. © Georg Thieme Verlag Stuttgart - New York. | en |
dc.source | Synthesis | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77953262786&doi=10.1055%2fs-0029-1217059&partnerID=40&md5=c88002ae68cd4dd2da9d5bae2b17d48a | |
dc.subject | article | en |
dc.subject | unclassified drug | en |
dc.subject | Synthesis (chemical) | en |
dc.subject | synthesis | en |
dc.subject | Chlorine compounds | en |
dc.subject | chemical structure | en |
dc.subject | proton nuclear magnetic resonance | en |
dc.subject | carbon nuclear magnetic resonance | en |
dc.subject | dehalogenation | en |
dc.subject | 4,5 dichloro 1,2,3 dithiazolium chloride | en |
dc.subject | Appel salt | en |
dc.subject | electrophilicity | en |
dc.subject | Quantitative yields | en |
dc.subject | DBU | en |
dc.subject | 2 cyano cyanothioformanilide derivative | en |
dc.subject | benzonitrile | en |
dc.subject | 1,8 diazabicyclo [5.4.0]undec 7 ene | en |
dc.subject | 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino) 4 methoxy benzonitrile | en |
dc.subject | 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino) 4,5 dimethoxybenzonitrile | en |
dc.subject | 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino) 5 nitrobenzonitrile | en |
dc.subject | 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino) 6 methylbenzonitrile | en |
dc.subject | 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino)benzonitrile | en |
dc.subject | 2 (cyanothioformamido) 4 methoxybenzonitrile | en |
dc.subject | 2 (cyanothioformamido) 4,5 dimethoxybenzonitrile | en |
dc.subject | 2 (cyanothioformamido) 5 nitrobenzonitrile | en |
dc.subject | 2 (cyanothioformamido) 6 methylbenzonitrile | en |
dc.subject | 2 (cyanothioformamido)benzonitrile | en |
dc.subject | 2 isothiocyanatobenzonitrile | en |
dc.subject | 4 chloro 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino)benzonitrile | en |
dc.subject | 4 chloro 2 (cyanothioformamido)benzonitrile | en |
dc.subject | 5 chloro 2 (4 chloro 5h 1,2,3 dithiazol 5 ylideneamino)benzonitrile | en |
dc.subject | 5 chloro 2 (cyanothioformamido)benzonitrile | en |
dc.subject | Benzonitriles | en |
dc.subject | Cyanothioformanilide | en |
dc.subject | Diels Alder reaction | en |
dc.subject | Isothiocyanate | en |
dc.subject | Isothiocyanates | en |
dc.subject | isothiocyanic acid derivative | en |
dc.title | The synthesis of 2-cyano-cyanothioformanilides from 2-(4-Chloro-5H-1,2,3- dithiazol-5-ylideneamino)benzonitriles using DBU | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1055/s-0029-1217059 | |
dc.description.issue | 24 | |
dc.description.startingpage | 4167 | |
dc.description.endingpage | 4174 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :16</p> | en |
dc.source.abbreviation | Synthesis | en |
dc.contributor.orcid | Koutentis, Panayiotis Andreas [0000-0002-4652-7567] | |
dc.gnosis.orcid | 0000-0002-4652-7567 | |