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Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-24)
NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...
EZH2: Role in breast cancer and potential therapeutic applications
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
Human diseases, most notably cancer, are frequently associated with epigenetic dysregulation. Epigenetic modifications control gene function beyond the underlying sequence and are heritable but reversible alterations in ...