• Master Thesis  Open Access
  
  

  Extracellular Regulated Kinase (ERK): A novel regulator in the development and function of cilia 

  Nikolaou, Chrystalla S. (2023-06-14)

  The role of cilia in biomedicine is becoming more and more recognized since defects in ciliary structure and function induce ciliopathies such as cystic kidney disease, neurological anomalies, obesity, blindness, and ...

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• Master Thesis  Open Access
  
  

  Quantifying the fragmentation levels of amphibian, reptile, and terrestrial mammal habitats inside and outside of Natura 2000 sites within the European Union 

  Economides, Sophia (2023-05-25)

  Natural landscapes are constantly being modified and fragmented through a plethora of human activities, such as urbanisation and agriculture. Landscape fragmentation can have multiple negative effects on biodiversity. For ...

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• Master Thesis  Open Access
  
  

  Investigating the role of Methyl CpG Binding proteins in Cervical Cancer 

  Patera, Eleftherios (2023-05-12)

  DNA methylation (5mC) is one of the main epigenetic modifications that drive gene regulation. Methyl CpG binding proteins (MBDs) bind methylated DNA and recruit the nucleosome remodelling and deacetylase complex (Nurd) ...

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• Master Thesis  
  
  

  Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response 

  Papa, Christina C. (2023-05-28)

  N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...

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• Master Thesis  
  
  

  Establishment of an N-terminal acetylation enzymatic assay to validate novel substrates and to identify inhibitors of NAA40 

  Kouma, Maria P. (2023-05-24)

  NAA40 (N-alpha acetyltransferase 40) is a member of the extended family of NATs (N-terminal acetyltransferases) which deposit acetyl groups on the N-terminal ends of proteins. NAA40 is a highly selective NAT, and its two ...

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• Master Thesis  Open Access
  
  

  The HPV16 E6 and E7 oncogenes modify Glutamine metabolism in Cervical Cancers 

  Andreou, Vasiliki (2023-05-18)

  Metabolic reprogramming is an established hallmark of cancer. Malignant cells induce metabolic adjustments to meet their high energy demands and sustain rapid proliferation. These metabolic changes involve modifications ...

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• Master Thesis  Open Access
  
  

  Molecular pathways affected by HBx protein and their targeting for therapy of Hepatocellular carcinoma 

  Ketti, Stavriani A. (2022-12-09)

  Hepatitis B virus (HBV) infection can cause several types of liver disease including acute hepatitis, chronic hepatitis, and liver cirrhosis. It is also considered a significant risk factor for Hepatocellular carcinoma ...

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• Master Thesis  Open Access
  
  

  Investigation of the role of cytoskeleton protein KATNAL2 in ribosomal gene transcription in mouse cells 

  Timotheou, Kyriaki M (2023-05-23)

  The discovery that katanin-like cytoskeleton protein KATNAL2, in addition to its intracellular localization at MTs and sites associated with MTs (centrioles, cilia), also, unexpectedly, resides in the nucleolus, suggests ...

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• Master Thesis  Open Access
  
  

  Novel molecular approaches to treat colorectal cancer 

  Argyrou, Christina (2021-12-10)

  Colorectal cancer is found to be the third most common type of cancer which has raised cases and mortality rate, worldwide. Patients with colorectal cancer, depending on tumour stage, undergo surgery, followed by either ...

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• Master Thesis  
  
  

  Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern 

  Aristokleous, Antonia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)

  The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...

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• Master Thesis  Open Access
  
  

  Mechanical Cell Membrane stimulation using Magnetic Tweezers increases cell membrane stiffness through integrin dependent and independent mechanisms 

  Michanikou, Antonis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)

  Several cellular processes, such as proliferation, migration tissue morphogenesis and tissue regeneration, are closely regulated by the cells ability to sense their microenvironment and translate mechanical stimuli to ...

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• Master Thesis  Open Access
  
  

  Human immune responses upon SARS-CoV-2 infection- inflammation and cytokine storm 

  Syrimi, Andriani (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12)

  Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in December 2019 in the city of Wuhan, China, causing the COVID-19 pandemic of acute respiratory ...

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• Master Thesis  Open Access
  
  

  Application of conservation genetics in conservation planning, with a special focus on the impacts of hybridization on birds and their conservation 

  Hajjar, Vanessa (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-06-01)

  Biodiversity consists of all different live forms found in Earth. It is important to sustain it as it has several important aspects, such as maintaining ecosystems, helping with their proper functioning and it also plays ...

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• Master Thesis  Open Access
  
  

  Adherens Junctions spatially guide ECM deposition by stimulating integrin activation and clustering 

  Zheltkova, Maria (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)

  The extracellular matrix (ECM) plays an essential role in all multicellular organisms as a substrate for cell anchorage and tissue scaffolding. It is involved in diverse processes such as cell proliferation and survival, ...

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• Master Thesis  Open Access
  
  

  Genetic Characterization of a Novel HIV-1 Circulating Recombinant Form (CRF91_cpx) and Identification of Three Additional Putative CRFs: Increased Prevalence of URFs and CRFs in the Polyphyletic HIV-1 Infection in Cyprus. 

  Georgiou, Vasilis (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-27)

  HIV is characterized by a high degree of genetic variation, as it is evident from numerous genetically distinct subtypes (within the major group M) and circulating recombinant forms (CRFs). The genetic diversity of HIV is ...

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• Master Thesis  Open Access
  
  

  Recombinant Poliovirus a therapeutic agent for Cancer 

  Mbonu, Helen (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05)

  Cancer is a leading cause of global mortality, and its burden is growing despite the availability of standard treatment methods. Genetically and Morphologically tumor cells differ from normal cells. However, cancers arise ...

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• Master Thesis  Open Access
  
  

  Spatiotemporal vocal interactions in a ground-dwelling Neotropical passerine 

  Elia, Stavroula (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-11)

  In many species, communication involves an exchange of information between the sender and the receiver, by using different types of signals. Among the different types of communication, acoustic communication has been studied ...

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• Master Thesis  Open Access
  
  

  The nexus between circRNA and prostate cancer from the complex interventions to treatment expectation 

  Alshikh Saleh, Ahmad (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-05-20)

  Circular RNAs (circRNAs) are a kind of RNA that results through a non-regular process known as alternative splicing. Because of their possible regulatory activities during gene expression, circRNAs have lately sparked ...

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• Master Thesis  Open Access
  
  

  Hypomethylation of Alu Elements in chronic lymphocytic leukemia 

  Prodromou, Marios (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)

  CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...

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• Master Thesis  Open Access
  
  

  Detection of SARS-CoV-2 in Clinical Samples Using Mismatch-Tolerant Molecular Beacons and Real-Time RT-PCR 

  Stathi, Georgia (Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-14)

  Infectious diseases that arise from pathogens are considered as a major threat towards global public health. Most recently, the novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...

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