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Development of a de novo Molecular Beacon-Based Real-Time RT-PCR Assay for the Detection and Discrimination of SARS-CoV-2 Variants of Concern
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2022-12-16)
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerged in late 2019 and is the causative agent of the Coronavirus Disease 2019 (COVID-19). Since its emergence it has led to a global pandemic with devastating ...
The amyloid hypothesis of Alzheimer’s Disease and its current treatment
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2020-12-14)
Alzheimer’s disease (AD), a progressive neurodegenerative disorder, is the commonest cause of dementia in the elderly population worldwide. It is a multifactorial disorder, characterized by extracellular β-amyloid peptide ...
Bacterial Species Antagonizing Pseudomonas aeruginosa Infection
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
Microbial species rarely exist in isolation in nature. Epithelial interfaces, such as the bilaterian intestine or the mammalian lung, harbour polymicrobial communities increasing infection complexity at these sites. We ...
Investigating the role of N-alpha acetyltransferase 40 in the DNA Damage Response
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-05-28)
N-terminal acetylation (Nt-ac) is one of the most common, most abundant, and evolutionary conserved post-translational modifications (PTMs) found in eukaryotic cells. This modification is catalyzed by a family of enzymes ...
Modelling Glioblastoma Angiogenesis in Drosophila larvae
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-05-27)
Glioblastoma multiforme (GBM) is the most common malignant type of cancer of the Central Nervous System (CNS) and is characterized as highly angiogenic. Poor prognosis combined with short lifespan after diagnosis (⁓18 ...
Hypomethylation of Alu Elements in chronic lymphocytic leukemia
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-10)
CLL is a malignant disease characterized by the uncontrolled clonal proliferation of small, mature-appearing neoplastic dysfunctional CD5+ B lymphocytes in which is driven by changes in DNA methylation. Genetic alterations ...
The PINK1/Parkin-dependent mitophagy pathway and its role in Parkinson’s disease
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2024)
Parkinson's disease is the second most prevalent neurodegenerative disease, surpassed only by Alzheimer’s disease. The disease is relentless, progressive, and incurable, and there is a great need to understand its causes ...
Prostate Cancer Organoids in the Fight Against Prostate Cancer
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2023-12-13)
Ο καρκίνος του προστάτη είναι μία από τις κυριότερες ασθένειες που αυξάνουν τα ποσοστά νοσηρότητας και θνησιμότητας στους άνδρες παγκοσμίως. Παρά τη µεγάλη ετερογένεια µεταξύ των όγκων και των ασθενών, ο καρκίνος του ...
Detection of SARS-CoV-2 in Clinical Samples Using Mismatch-Tolerant Molecular Beacons and Real-Time RT-PCR
(Πανεπιστήμιο Κύπρου, Σχολή Θετικών και Εφαρμοσμένων Επιστημών / University of Cyprus, Faculty of Pure and Applied Sciences, 2021-12-14)
Infectious diseases that arise from pathogens are considered as a major threat towards global public health. Most recently, the novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome ...