dc.contributor.author | Kostrikis, Leondios G. | en |
dc.contributor.author | Hezka, Johana | en |
dc.contributor.author | Stylianou, Dora C. | en |
dc.contributor.author | Kostaki, Evangelia | en |
dc.contributor.author | Andreou, Maria | en |
dc.contributor.author | Kousiappa, Ioanna | en |
dc.contributor.author | Paraskevis, Dimitrios | en |
dc.contributor.author | Demetriades, Ioannis | en |
dc.creator | Kostrikis, Leondios G. | en |
dc.creator | Hezka, Johana | en |
dc.creator | Stylianou, Dora C. | en |
dc.creator | Kostaki, Evangelia | en |
dc.creator | Andreou, Maria | en |
dc.creator | Kousiappa, Ioanna | en |
dc.creator | Paraskevis, Dimitrios | en |
dc.creator | Demetriades, Ioannis | en |
dc.date.accessioned | 2021-01-22T09:28:54Z | |
dc.date.available | 2021-01-22T09:28:54Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 1932-6203 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/61925 | |
dc.description.abstract | A molecular epidemiology study of HIV-1 infection was conducted in one hundred diagnosed and untreated HIV-1-infected patients in Cyprus between 2010 and 2012, representing 65.4% of all the reported HIV-1 infections in Cyprus in this three-year period, using a previously defined enrolment strategy. Eighty-two patients were newly diagnosed (genotypic drug resistance testing within six months from diagnosis), and eighteen patients were HIV-1 diagnosed for a longer period or the diagnosis date was unknown. Phylogenetic trees of the pol sequences obtained in this study with reference sequences indicated that subtypes B and A1 were the most common subtypes present and accounted for 41.0 and 19.0% respectively, followed by subtype C (7.0%), F1 (8.0%), CRF02_AG (4.0%), A2 (2.0%), other circulating recombinant forms (CRFs) (7.0%) and unknown recombinant forms (URFs) (12%). Most of the newly-diagnosed study subjects were Cypriots (63%), males (78%) with median age 39 (Interquartile Range, IQR 33–48) reporting having sex with other men (MSM) (51%). A high rate of clustered transmission of subtype B drug-sensitive strains to reverse transcriptase and protease inhibitors was observed among MSM, twenty-eight out of forty-one MSM study subjects (68.0%) infected were implicated in five transmission clusters, two of which are sub-subtype A1 and three of which are subtype B strains. The two largest MSM subtype B clusters included nine and eight Cypriot men, respectively, living in all major cities in Cyprus. There were only three newly diagnosed patients with transmitted drug resistant HIV-1 strains, one study subject from the United Kingdom infected with subtype B strain and one from Romania with sub-subtype A2 strain, both with PI drug resistance mutation M46L and one from Greece with sub-subtype A1 with non-nucleoside reverse transcriptase inhibitors (NNRTI) drug resistance mutation K103N. | en |
dc.language.iso | en | en |
dc.source | PLOS ONE | en |
dc.source.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0195660 | |
dc.title | HIV-1 transmission networks across Cyprus (2010-2012) | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1371/journal.pone.0195660 | |
dc.description.volume | 13 | |
dc.description.issue | 4 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.source.abbreviation | PLOS ONE | en |
dc.contributor.orcid | Kostrikis, Leondios G. [0000-0002-5340-7109] | |
dc.contributor.orcid | Stylianou, Dora C. [0000-0003-4167-1380] | |
dc.contributor.orcid | Paraskevis, Dimitrios [0000-0001-6167-7152] | |
dc.gnosis.orcid | 0000-0002-5340-7109 | |
dc.gnosis.orcid | 0000-0003-4167-1380 | |
dc.gnosis.orcid | 0000-0001-6167-7152 | |