An intrinsically disordered proteins community for ELIXIR
Date
2019Author
Davey, Norman E.Babu, M. Madan
Blackledge, Martin
Bridge, Alan
Capella-Gutierrez, Salvador
Dosztanyi, Zsuzsanna
Drysdale, Rachel
Edwards, Richard J.
Elofsson, Arne
Felli, Isabella C.
Gibson, Toby J.
Gutmanas, Aleksandras
Hancock, John M.
Harrow, Jen
Higgins, Desmond
Jeffries, Cy M.
Le Mercier, Philippe
Mészáros, Balint
Necci, Marco
Notredame, Cedric
Orchard, Sandra
Ouzounis, Christos A.
Pancsa, Rita
Papaleo, Elena
Pierattelli, Roberta
Piovesan, Damiano
Promponas, Vasilis J.
Ruch, Patrick
Rustici, Gabriella
Romero, Pedro
Sarntivijai, Sirarat
Saunders, Gary
Schuler, Benjamin
Sharan, Malvika
Shields, Denis C.
Sussman, Joel L.
Tedds, Jonathan A.
Tompa, Peter
Turewicz, Michael
Vondrasek, Jiri
Vranken, Wim F.
Wallace, Bonnie Ann
Wichapong, Kanin
Tosatto, Silvio C. E.
ISSN
2046-1402Source
F1000ResearchVolume
8Google Scholar check
Metadata
Show full item recordAbstract
Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) are now recognised as major determinants in cellular regulation. This white paper presents a roadmap for future e-infrastructure developments in the field of IDP research within the ELIXIR framework. The goal of these developments is to drive the creation of high-quality tools and resources to support the identification, analysis and functional characterisation of IDPs. The roadmap is the result of a workshop titled “An intrinsically disordered protein user community proposal for ELIXIR” held at the University of Padua. The workshop, and further consultation with the members of the wider IDP community, identified the key priority areas for the roadmap including the development of standards for data annotation, storage and dissemination integration of IDP data into the ELIXIR Core Data Resources and the creation of benchmarking criteria for IDP-related software. Here, we discuss these areas of priority, how they can be implemented in cooperation with the ELIXIR platforms, and their connections to existing ELIXIR Communities and international consortia. The article provides a preliminary blueprint for an IDP Community in ELIXIR and is an appeal to identify and involve new stakeholders.