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dc.contributor.advisorAndreou, Chrysafisen
dc.contributor.authorKekkou, Kyriakien
dc.coverage.spatialCyprusen
dc.creatorKekkou, Kyriakien
dc.date.accessioned2024-05-30T05:43:12Z
dc.date.available2024-05-30T05:43:12Z
dc.date.issued2024-05
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/66224en
dc.description.abstractOrgans-on-chip are microfluidic devices that recapitulate the micro-environment of biological tissues. They offer a platform to study the organ’s physiology, in health and disease, and enable highly controlled experiments for therapeutics, drugs, as well as more basic biological studies. This technology can replace animal testing, which is clearly a cruel, unethical, and ineffective way to carry out experiments. It has been established that results from animal tests are unreliable due to the differences between them and the human body. Additionally, organ-on-chip platforms are cost-effective and easily customizable. This work focuses on the development of a “Gut-on-a-chip”. Gastrointestinal (GI) cancer makes up 26% of the new cancer cases worldwide. GI cancer is one of the biggest challenges that the modern world has to face and its early detection and treatment are among the priorities of the cancer research community. Through this work, we built the hardware related to a gut-on-a-chip device. Specifically, we designed and fabricated the microfluidic device using soft lithography and 3D printing, as well as the pneumatic and fluidic controls to actuate the device. The mechanical actuation was measured using optical microscopy and image processing.en
dc.language.isoengen
dc.publisherΠανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightsOpen Accessen
dc.titleDevelopment and Validation of the Actuation and Control System for a Gut-on-Chip Deviceen
dc.typeinfo:eu-repo/semantics/masterThesisen
dc.contributor.committeememberPitris, Constantinosen
dc.contributor.committeememberChli, Margaritaen
dc.contributor.departmentΠανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή, Τμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστώνel
dc.contributor.departmentUniversity of Cyprus, Faculty of Engineering, Department of Electrical and Computer Engineeringen
dc.subject.uncontrolledtermGUT-ON-A-CHIPen
dc.subject.uncontrolledtermORGAN-ON-CHIPen
dc.subject.uncontrolledtermMICROFLUIDIC DEVICESen
dc.author.facultyΠολυτεχνική Σχολή / Faculty of Engineering
dc.author.departmentΤμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών / Department of Electrical and Computer Engineering
dc.type.uhtypeMaster Thesisen
dc.contributor.orcidAndreou, Chrysafis [0000-0002-3464-9110]
dc.contributor.orcidPitris, Constantinos [0000-0002-5559-1050]
dc.contributor.orcidChli, Margarita [0000-0001-5611-7492]
dc.gnosis.orcid0000-0002-3464-9110
dc.gnosis.orcid0000-0002-5559-1050
dc.gnosis.orcid0000-0001-5611-7492


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