dc.contributor.advisor | Andreou, Chrysafis | en |
dc.contributor.author | Kekkou, Kyriaki | en |
dc.coverage.spatial | Cyprus | en |
dc.creator | Kekkou, Kyriaki | en |
dc.date.accessioned | 2024-05-30T05:43:12Z | |
dc.date.available | 2024-05-30T05:43:12Z | |
dc.date.issued | 2024-05 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/66224 | en |
dc.description.abstract | Organs-on-chip are microfluidic devices that recapitulate the micro-environment of biological tissues. They offer a platform to study the organ’s physiology, in health and disease, and enable highly controlled experiments for therapeutics, drugs, as well as more basic biological studies. This technology can replace animal testing, which is clearly a cruel, unethical, and ineffective way to carry out experiments. It has been established that results from animal tests are unreliable due to the differences between them and the human body. Additionally, organ-on-chip platforms are cost-effective and easily customizable. This work focuses on the development of a “Gut-on-a-chip”. Gastrointestinal (GI) cancer makes up 26% of the new cancer cases worldwide. GI cancer is one of the biggest challenges that the modern world has to face and its early detection and treatment are among the priorities of the cancer research community. Through this work, we built the hardware related to a gut-on-a-chip device. Specifically, we designed and fabricated the microfluidic device using soft lithography and 3D printing, as well as the pneumatic and fluidic controls to actuate the device. The mechanical actuation was measured using optical microscopy and image processing. | en |
dc.language.iso | eng | en |
dc.publisher | Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή / University of Cyprus, Faculty of Engineering | |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.rights | Open Access | en |
dc.title | Development and Validation of the Actuation and Control System for a Gut-on-Chip Device | en |
dc.type | info:eu-repo/semantics/masterThesis | en |
dc.contributor.committeemember | Pitris, Constantinos | en |
dc.contributor.committeemember | Chli, Margarita | en |
dc.contributor.department | Πανεπιστήμιο Κύπρου, Πολυτεχνική Σχολή, Τμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών | el |
dc.contributor.department | University of Cyprus, Faculty of Engineering, Department of Electrical and Computer Engineering | en |
dc.subject.uncontrolledterm | GUT-ON-A-CHIP | en |
dc.subject.uncontrolledterm | ORGAN-ON-CHIP | en |
dc.subject.uncontrolledterm | MICROFLUIDIC DEVICES | en |
dc.author.faculty | Πολυτεχνική Σχολή / Faculty of Engineering | |
dc.author.department | Τμήμα Ηλεκτρολόγων Μηχανικών και Μηχανικών Υπολογιστών / Department of Electrical and Computer Engineering | |
dc.type.uhtype | Master Thesis | en |
dc.contributor.orcid | Andreou, Chrysafis [0000-0002-3464-9110] | |
dc.contributor.orcid | Pitris, Constantinos [0000-0002-5559-1050] | |
dc.contributor.orcid | Chli, Margarita [0000-0001-5611-7492] | |
dc.gnosis.orcid | 0000-0002-3464-9110 | |
dc.gnosis.orcid | 0000-0002-5559-1050 | |
dc.gnosis.orcid | 0000-0001-5611-7492 | |