dc.contributor.author | Ahmed, Ahmed | en |
dc.contributor.author | Efthymiou, Constantinos G. | en |
dc.contributor.author | Sanii, Rana | en |
dc.contributor.author | Patyk-Kazmierczak, Ewa | en |
dc.contributor.author | Alsharabasy, Amir M. | en |
dc.contributor.author | Winterlich, Meghan | en |
dc.contributor.author | Kumar, Naveen | en |
dc.contributor.author | Sensharma, Debobroto | en |
dc.contributor.author | Tong, Wenming | en |
dc.contributor.author | Guerin, Sarah | en |
dc.contributor.author | Farras, Pau | en |
dc.contributor.author | Hudson, Sarah | en |
dc.contributor.author | Thompson, Damien | en |
dc.contributor.author | Zaworotko, Michael J. | en |
dc.contributor.author | Tasiopoulos, Anastasios J. | en |
dc.contributor.author | Papatriantafyllopoulou, Constantina | en |
dc.contributor.editor | Cornelissen, Jeroen | en |
dc.coverage.spatial | Cambridge, UK | en |
dc.creator | Ahmed, Ahmed | en |
dc.creator | Efthymiou, Constantinos G. | en |
dc.creator | Sanii, Rana | en |
dc.creator | Patyk-Kazmierczak, Ewa | en |
dc.creator | Alsharabasy, Amir M. | en |
dc.creator | Winterlich, Meghan | en |
dc.creator | Kumar, Naveen | en |
dc.creator | Sensharma, Debobroto | en |
dc.creator | Tong, Wenming | en |
dc.creator | Guerin, Sarah | en |
dc.creator | Farras, Pau | en |
dc.creator | Hudson, Sarah | en |
dc.creator | Thompson, Damien | en |
dc.creator | Zaworotko, Michael J. | en |
dc.creator | Tasiopoulos, Anastasios J. | en |
dc.creator | Papatriantafyllopoulou, Constantina | en |
dc.date.accessioned | 2024-09-03T09:22:26Z | |
dc.date.available | 2024-09-03T09:22:26Z | |
dc.date.issued | 2022-03-02 | |
dc.identifier.issn | 2050-7518 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/66373 | en |
dc.description.abstract | Metal-organic frameworks (MOFs) are promising multifunctional porous materials for biomedical and environmental applications. Here, we report synthesis and characterization of a new MOF based on the tetrahedral secondary building unit [Zn4O(CBAB)3]n (NUIG4), where CBABH2 = 4-((4-carboxybenzylidene)amino)benzoic acid. NUIG4 belongs to the family of MOFs with primitive cubic pcu topology, being a rare example with 4-fold interpenetration. The pore architecture enables unprecedentedly high doxorubicin (DOX) loading capacity (1955 mg DOX/g NUIG4) with pH-controlled release. Solid-state NMR and ab initio modeling confirmed formation of aromatic π-π stacking interactions between DOX and the framework. Preliminary cell-line experiments suggested a protective effect of NUIG4 on healthy HDF cells against DOX toxicity. NUIG4 also displays potential for adsorptive small-molecule gas separation, with a BET surface area of 1358 m2 g-1 and high selectivity of 2.75 for C2H2 over CO2. | en |
dc.language.iso | eng | en |
dc.publisher | Royal Society of Chemistry | en |
dc.source | Journal of materials chemistry. B | en |
dc.source.uri | https://pubs.rsc.org/en/content/articlelanding/2022/tb/d1tb02176a | en |
dc.subject | Adsorption | en |
dc.subject | Doxorubicin | en |
dc.subject | Metal-organic frameworks (MOFs) | en |
dc.subject | Porosity | en |
dc.subject | Doxorubicin | en |
dc.subject | Metal organic framework | en |
dc.subject | Adsorption | en |
dc.subject | Chemistry | en |
dc.subject | Porosity | en |
dc.title | NUIG4: a biocompatible pcu metal-organic framework with an exceptional doxorubicin encapsulation capacity | en |
dc.type | info:eu-repo/semantics/article | en |
dc.identifier.doi | 10.1039/d1tb02176a | |
dc.description.volume | 10 | |
dc.description.issue | 9 | |
dc.description.startingpage | 1378 | |
dc.description.endingpage | 1385 | |
dc.author.faculty | 002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Χημείας / Department of Chemistry | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Ahmed, Ahmed [0000-0002-9197-7786] | en |
dc.contributor.orcid | Efthymiou, Constantinos G. [0009-0007-4852-4304] | |
dc.contributor.orcid | Sanii, Rana [0000-0003-4813-9987] | |
dc.contributor.orcid | Patyk-Kazmierczak, Ewa [0000-0002-5865-7473] | |
dc.contributor.orcid | Alsharabasy, Amir M. [0000-0002-8503-5549] | |
dc.contributor.orcid | Winterlich, Meghan [0000-0003-0681-9212] | |
dc.contributor.orcid | Kumar, Naveen [0009-0006-2397-9495] | |
dc.contributor.orcid | Sensharma, Debobroto [0000-0002-4918-0730] | |
dc.contributor.orcid | Tong, Wenming [0000-0002-4831-4960] | |
dc.contributor.orcid | Guerin, Sarah [0000-0002-2442-4022] | |
dc.contributor.orcid | Farras, Pau [0000-0003-3859-2868] | |
dc.contributor.orcid | Hudson, Sarah [0000-0002-6718-2190] | |
dc.contributor.orcid | Thompson, Damien [0000-0003-2340-5441] | |
dc.contributor.orcid | Zaworotko, Michael J. [0000-0002-1360-540X] | |
dc.contributor.orcid | Tasiopoulos, Anastasios J. [0000-0002-4804-3822] | |
dc.contributor.orcid | Papatriantafyllopoulou, Constantina [0000-0002-5652-7747] | |
dc.type.subtype | SCIENTIFIC_JOURNAL | en |
dc.gnosis.orcid | 0000-0002-9197-7786 | |
dc.gnosis.orcid | 0009-0007-4852-4304 | |
dc.gnosis.orcid | 0000-0003-4813-9987 | |
dc.gnosis.orcid | 0000-0002-5865-7473 | |
dc.gnosis.orcid | 0000-0002-8503-5549 | |
dc.gnosis.orcid | 0000-0003-0681-9212 | |
dc.gnosis.orcid | 0009-0006-2397-9495 | |
dc.gnosis.orcid | 0000-0002-4918-0730 | |
dc.gnosis.orcid | 0000-0002-4831-4960 | |
dc.gnosis.orcid | 0000-0002-2442-4022 | |
dc.gnosis.orcid | 0000-0003-3859-2868 | |
dc.gnosis.orcid | 0000-0002-6718-2190 | |
dc.gnosis.orcid | 0000-0003-2340-5441 | |
dc.gnosis.orcid | 0000-0002-1360-540X | |
dc.gnosis.orcid | 0000-0002-4804-3822 | |
dc.gnosis.orcid | 0000-0002-5652-7747 | |