Browsing by Author "Constantinou, Andreas I."
Now showing items 1-20 of 87
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Article
Altered Phosphorylation, Biosynthesis and Degradation of the 170 kDa Isoform of Topoisomerase II in Amsacrine-Resistant Human Leukemia Cells
Ganapathi, R.; Zwelling, L.; Constantinou, Andreas I.; Ford, J.; Grabowski, D. (1993)Resistance to amsacrine in HL-60/AMSA is 50-100 fold compared to the parental HL-60/S cells. Synthesis and phosphorylation of topoisomerase II (TOPO II) were 2-3 fold lower in HL-60/AMSA compared to HL-60/S cells metabolically ...
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Article
Application of topoisomerase assays in the evaluation of natural products as antitumor agents
Constantinou, Andreas I.; Salti, G. (1999)Initially, DNA topoisomerase (topo) inhibitors found clinical applications as antibiotics and cancer chemotherapeutic agents. Recently, we demonstrated that plant flavonoids that inhibit mammalian topo I or topo II might ...
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Article
Attenuation of drug-stimulated topoisomerase II-DNA cleavable complex formation in wild-type HL-60 cells treated with an intracellular calcium buffer is correlated with decreased cytotoxicity and site-specific hypophosphorylation of topoisomerase IIα
Aoyama, M.; Grabowski, D. R.; Dubyak, G. R.; Constantinou, Andreas I.; Rybicki, L. A.; Bukowski, R. M.; Ganapathi, M. K.; Hickson, I. D.; Ganapathi, R. (1998)Topoisomerase II (topo II), an essential enzyme for cell viability, is also the target for clinically important anti-neoplastic agents that stimulate topo II-mediated DNA scission. The role of alterations in topo IIα ...
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Article
Automated scientific assistant for Cancer and Chemoprevention
Lazarou, S.; Kakas, Antonis C.; Neophytou, Christiana M.; Constantinou, Andreas I. (2013)Logical modeling of cell biological phenomena has the potential to facilitate both the understanding of the mechanisms that underly the phenomena as well as the process of experimentation undertaken by the biologist. ...
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Article
Bacterial cupredoxin azurin as an inducer of apoptosis and regression in human breast cancer
Punj, V.; Bhattacharyya, S.; Saint-Dic, D.; Vasu, C.; Cunningham, E. A.; Graves, J.; Yamada, T.; Constantinou, Andreas I.; Christov, K.; White, B.; Li, G.; Majumdar, D.; Chakrabarty, A. M.; Das Gupta, T. K. (2004)Azurin, a copper-containing redox protein released by the pathogenic bacterium Pseudomonas aeruginosa, is highly cytotoxic to the human breast cancer cell line MCF-7, but is less cytotoxic toward p53-negative (MDA-MB-157) ...
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Article
Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27Kip1-dependent G1/S cell cycle arrest in conjunction with NF-κB activation
Batsi, Christina; Markopoulou, Soultana; Kontargiris, Evangelos; Charalambous, Christina; Thomas, Christoforos G.; Christoforidis, Savvas; Kanavaros, Panagiotis E.; Constantinou, Andreas I.; Marcu, Kenneth B.; Kolettas, Evangelos (2009)2-Methoxyestradiol (2-ME2) induces leukemia cells to undergo apoptosis in association with Bcl-2 inactivation but the mechanisms whereby Bcl-2 contributes to protection against programmed cell death in this context remain ...
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Article
Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: Evidence for a potential role as a chemopreventive agent
Salti, G. I.; Kichina, J. V.; Das Gupta, T. K.; Uddin, S.; Bratescu, L.; Pezzuto, J. M.; Mehta, R. G.; Constantinou, Andreas I. (2001)Melanoma transformation progresses in a multistep fashion from precursor lesions such as congenital naevi. Exposure to ultraviolet (UV) light promotes this process. Betulinic acid (BA) was identified by our group as a ...
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Article
Black cohosh (Cimicifuga racemosa L.) protects against menadione-induced DNA damage through scavenging of reactive oxygen species: Bioassay-directed isolation and characterization of active principles
Burdette, J. E.; Chen, S. -N; Lu, Z. -Z; Xu, H.; White, B. E. P.; Fabricant, D. S.; Liu, J.; Fong, H. H. S.; Farnsworth, N. R.; Constantinou, Andreas I.; Van Breemen, R. B.; Pezzuto, J. M.; Bolton, J. L. (2002)The roots/rhizomes of Cimicifuga racemosa L. (Nutt.) (black cohosh) have traditionally been used to treat menopausal symptoms through an unknown mechanism of action. In an effort to determine if black cohosh had additional ...
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Book Chapter
Breast Cancer Epigenetics
Pitta, Chara A.; Constantinou, Andreas I. (Elsevier Inc., 2015)The molecular mechanisms underlying the development and progression of breast cancer are far from being understood. It is obvious that the initiation of breast cancer as well as its transition toward distinct breast cancer ...
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Article
Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage
Mehta, R. G.; Liu, J.; Constantinou, Andreas I.; Thomas, C. F.; Hawthorne, M.; You, M.; Gerhäuser, C.; Pezzuto, J. M.; Moon, R. C.; Moriarty, R. M. (1995)Brassinin [3-(S-methyldithiocarbamoyl aminomethyl indole], a phytoalexin first identified as a constituent of cabbage, was synthesized and evaluated for cancer chemopreventive activity. Dose-dependent inhibition of ...
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Article
Caspase-independent pathways of programmed cell death: The unraveling of new targets of cancer therapy?
Constantinou, Constantina; Papas, Konstantinos A.; Constantinou, Andreas I. (2009)In the past few years, accumulating evidence in the literature supports the existence of pathways of caspase-independent programmed cell death (CI-PCD). These pathways are likely to be acting as 'death backup systems' that ...
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Article
Chemopreventive effects of soy protein and purified soy isoflavones on DMBA-induced mammary tumors in female Sprague-Dawley rats
Constantinou, Andreas I.; Lantvit, D.; Hawthorne, M.; Xu, X.; Van Breemen, R. B.; Pezzuto, J. M. (2001)There are conflicting reports on the effect of soy and its components on mammary carcinogenesis in adult female rats, mainly because of different rodent models that are used in chemoprevention studies. The present study ...
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Article
Commitment to erythroid differentiation in mouse erythroleukemia cells is controlled by alterations in topoisomerase IIα phosphorylation
Constantinou, Andreas I.; Vaughan, A. T. M.; Yamasaki, H.; Kamath, N. (1996)To explore the program of cell differentiation in Friend murine erythroleukemia (MEL) cells, we used three clonal variants: phorbol 12- myristate 13-acetate (PMA)-hypersensitive TS-19-101, PMA-resistant TR19-9, and ...
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Article
Comparison of Two Different Doses of Ondansetron plus Dexamethasone in the Prophylaxis of Cisplatin-lnduced Emesis
Pectasides, Dimitrios; Mylonakis, Alexander; Varthalitis, John; Kostopoulou, Mary; Constantinou, Andreas I.; Papazachariou, Kathrin; Antoniou, Fotini; Dimitriadis, Michael; Athanassiou, Athanassios E. (1997)This study was conducted to evaluate the efficacy of two different doses of ondansetron (8 mg vs. 24 mg) plus dexamethasone in the prevention of cisplatin (CDDP)-induced emesis and nausea (acute and delayed). The persistence ...
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Article
D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces cell cycle arrest and apoptosis selectively in Survivin-overexpressing breast cancer cells
Neophytou, Christiana M.; Constantinou, Constantina; Papageorgis, P.; Constantinou, Andreas I. (2014)d-alpha-tocopheryl polyethylene glycol succinate (TPGS) is a vitamin E derivative that has been intensively applied as a vehicle for drug delivery systems to enhance drug solubility and increase the oral bioavailability ...
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Article
The Dietary Anticancer Agent Ellagic Acid is a Potent Inhibitor of DNA Topoisomerases in Vitro
Constantinou, Andreas I.; Mehta, R.; Runyan, C.; Moon, R.; Stoner, G. D.; Rao, K. (1995)Ellagic acid and 12 related agents have been tested for their ability to inhibit the activities of human DNA topoisomerase (topo) I and IL Using specific in vitro assays, we found ellagic acid and flavellagic acid to be ...
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Article
Dietary retinoids and carotenoids in rodent models of mammary tumorigenesis
Moon, R. C.; Constantinou, Andreas I. (1997)In this review of the scientific literature the relationship between retinoids, carotenoids, and mammary carcinogenesis is examined. Several retinoids have shown promise as chemopreventive agents against chemically induced ...
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Article
Dietary Soy Isoflavones and Estrone Protect Ovariectomized ERαKO and Wild-Type Mice from Carcinogen-Induced Colon Cancer
Guo, J. -Y; Li, X.; Browning Jr., J. D.; Rottinghaus, G. E.; Lubahn, D. B.; Constantinou, Andreas I.; Bennink, M.; MacDonald, R. S. (2004)Consumption of soy foods has been weakly associated with reduced colon cancer risk. Colon cancer risk is influenced by estrogen exposure, although the mechanism through which this occurs is not defined. Conversion of ...
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Article
Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues
Mehta, R. G.; Mehta, R. R.; Constantinou, Andreas I.; Moon, R. C. (1995)Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
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Article
Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives
Neophytou, Christiana M.; Constantinou, Andreas I. (2015)Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E ...