Decreased centrality of cortical volume covariance networks in autism spectrum disorders
dc.contributor.author | Balardin, J. B. | en |
dc.contributor.author | Comfort, W. E. | en |
dc.contributor.author | Daly, Eileen M. | en |
dc.contributor.author | Murphy, Clodagh M. | en |
dc.contributor.author | Andrews, Derek Sayre | en |
dc.contributor.author | Murphy, Declan G. M. | en |
dc.contributor.author | Ecker, C. | en |
dc.contributor.author | Sato, J. R. | en |
dc.contributor.author | Bailey, Anthony J. | en |
dc.contributor.author | Baron-Cohen, Simon | en |
dc.contributor.author | Bolton, P. F. | en |
dc.contributor.author | Bullmore, Edward T. | en |
dc.contributor.author | Carrington, S. | en |
dc.contributor.author | Catani, Marco | en |
dc.contributor.author | Chakrabarti, B. | en |
dc.contributor.author | Craig, Michael C. | en |
dc.contributor.author | Daly, Eileen M. | en |
dc.contributor.author | Deoni, Sean C. L. | en |
dc.contributor.author | Happé, Francesca | en |
dc.contributor.author | Henty, Julian | en |
dc.contributor.author | Jezzard, Peter | en |
dc.contributor.author | Johnston, Patrick | en |
dc.contributor.author | Jones, D. K. | en |
dc.contributor.author | Lai, Meng-Chuan | en |
dc.contributor.author | Lombardo, Michael V. | en |
dc.contributor.author | Madden, A. | en |
dc.contributor.author | Mullins, D. | en |
dc.contributor.author | Murphy, Clodagh M. | en |
dc.contributor.author | Murphy, Declan G. M. | en |
dc.contributor.author | Pasco, Greg | en |
dc.contributor.author | Ruigrok, Amber N. V. | en |
dc.contributor.author | Sadek, Susan A. | en |
dc.contributor.author | Spain, D. | en |
dc.contributor.author | Stewart, R. | en |
dc.contributor.author | Suckling, John | en |
dc.contributor.author | Wheelwright, Sally J. | en |
dc.contributor.author | Williams, Steven C. R. | en |
dc.contributor.author | Wilson, C. E. | en |
dc.contributor.author | MRC AIMS Consortium | en |
dc.creator | Balardin, J. B. | en |
dc.creator | Comfort, W. E. | en |
dc.creator | Daly, Eileen M. | en |
dc.creator | Murphy, Clodagh M. | en |
dc.creator | Andrews, Derek Sayre | en |
dc.creator | Murphy, Declan G. M. | en |
dc.creator | Ecker, C. | en |
dc.creator | Sato, J. R. | en |
dc.creator | Bailey, Anthony J. | en |
dc.creator | Baron-Cohen, Simon | en |
dc.creator | Bolton, P. F. | en |
dc.creator | Bullmore, Edward T. | en |
dc.creator | Carrington, S. | en |
dc.creator | Catani, Marco | en |
dc.creator | Chakrabarti, B. | en |
dc.creator | Craig, Michael C. | en |
dc.creator | Daly, Eileen M. | en |
dc.creator | Deoni, Sean C. L. | en |
dc.creator | Happé, Francesca | en |
dc.creator | Henty, Julian | en |
dc.creator | Jezzard, Peter | en |
dc.creator | Johnston, Patrick | en |
dc.creator | Jones, D. K. | en |
dc.creator | Lai, Meng-Chuan | en |
dc.creator | Lombardo, Michael V. | en |
dc.creator | Madden, A. | en |
dc.creator | Mullins, D. | en |
dc.creator | Murphy, Clodagh M. | en |
dc.creator | Murphy, Declan G. M. | en |
dc.creator | Pasco, Greg | en |
dc.creator | Ruigrok, Amber N. V. | en |
dc.creator | Sadek, Susan A. | en |
dc.creator | Spain, D. | en |
dc.creator | Stewart, R. | en |
dc.creator | Suckling, John | en |
dc.creator | Wheelwright, Sally J. | en |
dc.creator | Williams, Steven C. R. | en |
dc.creator | Wilson, C. E. | en |
dc.creator | MRC AIMS Consortium | en |
dc.date.accessioned | 2017-07-27T10:21:26Z | |
dc.date.available | 2017-07-27T10:21:26Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/37106 | |
dc.description.abstract | Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions characterized by atypical structural and functional brain connectivity. Complex network analysis has been mainly used to describe altered network-level organization for functional systems and white matter tracts in ASD. However, atypical functional and structural connectivity are likely to be also linked to abnormal development of the correlated structure of cortical gray matter. Such covariations of gray matter are particularly well suited to the investigation of the complex cortical pathology of ASD, which is not confined to isolated brain regions but instead acts at the systems level. In this study, we examined network centrality properties of gray matter networks in adults with ASD (n = 84) and neurotypical controls (n = 84) using graph theoretical analysis. We derived a structural covariance network for each group using interregional correlation matrices of cortical volumes extracted from a surface-based parcellation scheme containing 68 cortical regions. Differences between groups in closeness network centrality measures were evaluated using permutation testing. We identified several brain regions in the medial frontal, parietal and temporo-occipital cortices with reductions in closeness centrality in ASD compared to controls. We also found an association between an increased number of autistic traits and reduced centrality of visual nodes in neurotypicals. Our study shows that ASD are accompanied by atypical organization of structural covariance networks by means of a decreased centrality of regions relevant for social and sensorimotor processing. These findings provide further evidence for the altered network-level connectivity model of ASD. © 2015 Elsevier Ltd. | en |
dc.source | Journal of psychiatric research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84940861663&doi=10.1016%2fj.jpsychires.2015.08.003&partnerID=40&md5=ff7198a5c6e5dd1df8511d2d53fb8444 | |
dc.subject | Autism | en |
dc.subject | Centrality | en |
dc.subject | Connectivity | en |
dc.subject | Graph theory | en |
dc.subject | Neuroanatomy | en |
dc.subject | Structural covariance | en |
dc.title | Decreased centrality of cortical volume covariance networks in autism spectrum disorders | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/j.jpsychires.2015.08.003 | |
dc.description.volume | 69 | |
dc.description.startingpage | 142 | |
dc.description.endingpage | 149 | |
dc.author.faculty | Σχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education | |
dc.author.department | Τμήμα Ψυχολογίας / Department of Psychology | |
dc.type.uhtype | Article | en |
dc.description.notes | Cited By :2; Export Date: 17 July 2017 | en |
dc.source.abbreviation | J.Psychiatr.Res. | en |
dc.contributor.orcid | Lombardo, Michael V. [0000-0001-6780-8619] | |
dc.gnosis.orcid | 0000-0001-6780-8619 |
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