dc.contributor.author | Floris, Dorothea L. | en |
dc.contributor.author | Lai,Meng-Chuan | en |
dc.contributor.author | Auer, Tibor | en |
dc.contributor.author | Lombardo,Michael V. | en |
dc.contributor.author | Ecker,C. | en |
dc.contributor.author | Chakrabarti,B. | en |
dc.contributor.author | Wheelwright,Sally J. | en |
dc.contributor.author | Bullmore,Edward T. | en |
dc.contributor.author | Murphy,Declan G. M. | en |
dc.contributor.author | Baron-Cohen,Simon | en |
dc.contributor.author | Suckling,John | en |
dc.creator | Floris, Dorothea L. | en |
dc.creator | Lai,Meng-Chuan | en |
dc.creator | Auer, Tibor | en |
dc.creator | Lombardo, Michael V. | en |
dc.creator | Ecker,C. | en |
dc.creator | Chakrabarti,B. | en |
dc.creator | Wheelwright,Sally J. | en |
dc.creator | Bullmore,Edward T. | en |
dc.creator | Murphy,Declan G. M. | en |
dc.creator | Baron-Cohen,Simon | en |
dc.creator | Suckling,John | en |
dc.date.accessioned | 2017-07-27T10:21:42Z | |
dc.date.available | 2017-07-27T10:21:42Z | |
dc.date.issued | 2016 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/37281 | |
dc.description.abstract | In humans, both language and fine motor skills are associated with left-hemisphere specialization, whereas visuospatial skills are associated with right-hemisphere specialization. Individuals with autism spectrum conditions (ASC) show a profile of deficits and strengths that involves these lateralized cognitive functions. Here we test the hypothesis that regions implicated in these functions are atypically rightward lateralized in individuals with ASC and, that such atypicality is associated with functional performance. Participants included 67 male, right-handed adults with ASC and 69 age- and IQ-matched neurotypical males. We assessed group differences in structural asymmetries in cortical regions of interest with voxel-based analysis of grey matter volumes, followed by correlational analyses with measures of language, motor and visuospatial skills. We found stronger rightward lateralization within the inferior parietal lobule and reduced leftward lateralization extending along the auditory cortex comprising the planum temporale, Heschl's gyrus, posterior supramarginal gyrus, and parietal operculum, which was more pronounced in ASC individuals with delayed language onset compared to those without. Planned correlational analyses showed that for individuals with ASC, reduced leftward asymmetry in the auditory region was associated with more childhood social reciprocity difficulties. We conclude that atypical cerebral structural asymmetry is a potential candidate neurophenotype of ASC. © 2015 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc. | en |
dc.source | Human brain mapping | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954387975&doi=10.1002%2fhbm.23023&partnerID=40&md5=100419665dede56316fa8d09dfa68e14 | |
dc.subject | Autism | en |
dc.subject | Cortical asymmetry | en |
dc.subject | Language delay | en |
dc.subject | Lateralization | en |
dc.subject | Volumetric mri | en |
dc.title | A typically rightward cerebral asymmetry in male adults with autism stratifies individuals with and without language delay | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/hbm.23023 | |
dc.description.volume | 37 | |
dc.description.issue | 1 | |
dc.description.startingpage | 230 | |
dc.description.endingpage | 253 | |
dc.author.faculty | Σχολή Κοινωνικών Επιστημών και Επιστημών Αγωγής / Faculty of Social Sciences and Education | |
dc.author.department | Τμήμα Ψυχολογίας / Department of Psychology | |
dc.type.uhtype | Article | en |
dc.description.notes | Cited By :9; Export Date: 17 July 2017 | en |
dc.source.abbreviation | Hum.Brain Mapp. | en |
dc.contributor.orcid | Lombardo, Michael V. [0000-0001-6780-8619] | |
dc.gnosis.orcid | 0000-0001-6780-8619 | |