Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 154-173 of 677
-
Article
DisProt: intrinsic protein disorder annotation in 2020
(2020)The Database of Protein Disorder (DisProt, URL: https://disprot.org) provides manually curated annotations of intrinsically disordered proteins from the literature. Here we report recent developments with DisProt (version ...
-
Article
Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance
(2018)Aim of the study Recent advances in understanding the underlying molecular mechanism for distal renal tubular acidosis (dRTA), led to an increased attention towards the primary and the familial forms of the disease. Mutations ...
-
Article
Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2
(2009)Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its ...
-
Article
-
Article
Distribution modelling of Eleonora's Falcon Falco eleonorae Géné, 1839 occurrence in its wintering grounds: A niche-based approach with satellite telemetry data
(2014)Summary Eleonora's Falcon is a long-distance migrant of the Palearctic region. In recent years, the advent of satellite telemetry has enabled a more detailed investigation of the species's migratory and wintering periods. ...
-
Article
Distribution of epidermal growth factor receptors in normal and neoplastic mammary tissues
(1995)Epidermal growth factor (EGF) is considered to be mitogenic for proliferation of mammary glands in animals. The action of EGF is mediated by specific EGF receptors (EGF-R). In the present study, we investigated distribution ...
-
Article
Diversification within an oceanic Mediterranean island: Insights from a terrestrial isopod
(ScienceDirect, 2022-07-08)Understanding intra-island patterns of evolutionary divergence, including cases of cryptic diversity, is a crucial step towards deciphering speciation processes. Cyprus is an oceanic island isolated for at least 5.3 Mya ...
-
Article
DNA barcoding of bird species in Cyprus: a tool for conservation purposes
(2017)DNA barcoding has become a widely used and valuable tool in taxonomic research during the past three decades and its application is expanding to fields such as wildlife forensics (e.g. anti-poaching actions). One of the ...
-
Article
DNA variant databases improve test accuracy and phenotype prediction in Alport syndrome
(2014)X-linked Alport syndrome is a form of progressive renal failure caused by pathogenic variants in the COL4A5 gene. More than 700 variants have been described and a further 400 are estimated to be known to individual ...
-
Article
Does by-catch pose a threat for the conservation of seabird populations in the southern ionian sea (eastern Mediterranean)? A questionnaire-based survey of local fisheries
(2013)A significant number of studies worldwide have shown that incidental catches (by-catch) of seabirds in fishing gear might pose a considerable risk for the conservation of their populations. Nevertheless, reliable data on ...
-
Article
A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis
(2013)FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...
-
Article
Down-regulation of glutatione S-transferase α 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection
(2012)Patients with severe burns are highly susceptible to bacterial infection. While immunosuppression facilitates infection, the contribution of soft tissues to infection beyond providing a portal for bacterial entry remains ...
-
Article
Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques
(1999)To determine the role of CD8+ T cells in controlling simian immunodeficiency virus (SIV) replication in vivo, we examined the effect of depleting this cell population using an anti-CD8 monoclonal antibody, OKT8F. There was ...
-
Article
Drosophila and the hallmarks of cancer
(2013): Cancer was the disease of the twentieth century. Today it is still a leading cause of death worldwide despite being intensively investigated. Abundant knowledge exists regarding the pathological and molecular mechanisms ...
-
Article
Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity
(2013)Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila ...
-
Article
Drosophila melanogaster as a model for human intestinal infection and pathology
(2011)Recent findings concerning Drosophila melanogaster intestinal pathology suggest that this model is well suited for the study of intestinal stem cell physiology during aging, stress and infection. Despite the physiological ...
-
Article
Drosophila melanogaster as a model host for studying Pseudomonas aeruginosa infection
(2009)Conservation of host signaling pathways and tissue physiology between Drosophila melanogaster and mammals allows for the modeling of human host-pathogen interactions in Drosophila. Here we present the use of genetically ...
-
Book Chapter
Drosophila melanogaster as a versatile model for the discovery of drugs effective against human Microbe-induced infection and pathology
(CABI Publishing, 2012)
-
Article
Drosophila melanogaster: A first step and a stepping-stone to anti-infectives
(2013)Following an expansion in the antibiotic drug discovery in the previous century, we now face a bottleneck in the production of new anti-infective drugs. Traditionally, chemical libraries are screened either using in vitro ...
-
Article
Drug delivery innovations for enhancing the anticancer potential of vitamin e isoforms and their derivatives
(2015)Vitamin E isoforms have been extensively studied for their anticancer properties. Novel drug delivery systems (DDS) that include liposomes, nanoparticles, and micelles are actively being developed to improve Vitamin E ...