Browsing Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences by Title
Now showing items 568-587 of 677
-
Article
A single base mutation in type I procollagen (COL1A1) that converts glycine α1-541 to aspartate in a lethal variant of osteogenesis imperfecta: Detection of the mutation with a carbodiimide reaction of DNA heteroduplexes and direct sequencing of products of the PCR
(1991)Skin fibroblasts from a proband with a lethal variant of osteogenesis imperfecta synthesized both apparently normal type I procollagen and a type I procollagen that had slow electrophoretic mobility because of posttranslational ...
-
Article
A single base mutation that converts glycine 907 of the α2(I) chain of type I procollagen to aspartate in a lethal variant of osteogenesis imperfecta. The single amino acid substitution near the carboxyl terminus destabilizes the whole triple helix
(1989)Type I procollagen was examined in cultured skin fibroblasts from a patient with a lethal variant of osteogenesis imperfecta. About half of the pro-α chains were post-translationally overmodified and had a decreased thermal ...
-
Article
Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory
(2020)Transcriptional memory of gene expression enables adaptation to repeated stimuli across many organisms. However, the regulation and heritability of transcriptional memory in single cells and through divisions remains poorly ...
-
Article
Single-shot optical sectioning using two-color probes in HiLo fluorescence microscopy
(2011)We describe a wide-field fluorescence microscope setup which combines HiLo microscopy technique with the use of a two-color fluorescent probe. It allows one-shot fluorescence optical sectioning of thick biological moving ...
-
Article
Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy
(2019)Intracellular accumulation of misfolded proteins causes toxic proteinopathies, diseases without targeted therapies. Mucin 1 kidney disease (MKD) results from a frameshift mutation in the MUC1 gene (MUC1-fs). Here, we show ...
-
Article
Smithornis broadbills produce loud wing song by aeroelastic flutter of medial primary wing feathers
(2016)Broadbills in the genus Smithornis produce a loud brreeeeet during a distinctive flight display. It has been posited that this klaxon-like sound is generated non-vocally with the outer wing feathers (P9, P10), but no ...
-
Article
Solubilization and stabilization of carotenoids using micelles: Delivery of lycopene to cells in culture
(1999)The use of the organic cosolvents tetrahydrofuran and dimethylsulfoxide was found to be unsuitable for prostate tumor cell cultures because of solvent cytotoxicity and the poor solubility and instability of lycopene. For ...
-
Article
Somatic cell mosaicism: Another source of phenotypic heterogeneity in nuclear families with osteogenesis imperfecta
(1993)Mutations in the genes coding for the proα1 and proα2 chains of type I procollagen have been found in many patients with osteogenesis imperfecta (OI), a heritable disorder of connective tissue. The severity of the disease ...
-
Article
-
Article
The soy isoflavone daidzein improves the capacity of tamoxifen to prevent mammary tumours
(2005)The aim of this study was to determine how the efficacy of tamoxifen is affected when combined with soy isoflavones. To address this, female Sprague-Dawley rats were placed on diets supplemented with tamoxifen, genistein, ...
-
Article
Soy protein isolate prevents chemically-induced rat mammary tumors
(2002)purified daidzein at 200 mg/kg diet
-
Article
Spatially and temporally regulated α6 integrin cleavage during Xenopus laevis development
(2008)The α6 integrin is essential for early nervous system development in Xenopus laevis. We have previously reported a uPA cleaved form of integrin α6 (α6p), in invasive human prostate cancer tissue, whose presence correlates ...
-
Article
Species co-occurrence: The case of congeneric species and a causal approach to patterns of species association
(2006)Aim: To test whether congeneric species are significantly associated with one another in space, either positively or negatively. Also, to provide a framework for a causal investigation of co-occurrence patterns by a parallel ...
-
Article
-
Article
The species-area relationship of terrestrial isopods (Isopoda
(1996)Data on species richness of terrestrial isopods (Oniscidea) from central Aegean islands (Greece), together with previously published data sets from other taxa and areas, are critically analysed under the basic premises of ...
-
Article
Spectral genotyping of human alleles
(1998)
-
Article
Split-Inteins for Simultaneous, site-specific conjugation of Quantum Dots to multiple protein targets In vivo
(2011)Background: Proteins labelled with Quantum Dots (QDs) can be imaged over long periods of time with ultrahigh spatial and temporal resolution, yielding important information on the spatiotemporal dynamics of proteins within ...
-
Article
Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells
(2003)We previously reported stable transfection of estrogen receptor alpha (ERα) into the ER-negative MDA-MB-231 cells (S30) as a tool to examine the mechanism of action of estrogen and antiestrogens [J. Natl. Cancer Inst. 84 ...
-
Article
-
Article
The story of a rock-star: multilocus phylogeny and species delimitation in the starred or roughtail rock agama, Laudakia stellio (Reptilia: Agamidae)
(Oxford Academic, 2022-01-31)Situated at the junction of three continents, Europe, Asia and Africa, the Eastern Mediterranean is an ideal region to study the effects of palaeogeography, ecology and long human presence on animal evolution. Laudakia ...