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Activation of endogenous FAK via expression of its amino terminal domain in xenopus embryos
(2012)
Background: The Focal Adhesion Kinase is a well studied tyrosine kinase involved in a wide number of cellular processes including cell adhesion and migration. It has also been shown to play important roles during embryonic ...
A ligand-independent integrin β1 mechanosensory complex guides spindle orientation
(2016)
Control of spindle orientation is a fundamental process for embryonic development, morphogenesis and tissue homeostasis, while defects are associated with tumorigenesis and other diseases. Force sensing is one of the ...
A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis
(2013)
FAK is a non-receptor tyrosine kinase involved in a wide variety of biological processes and crucial for embryonic development. In this manuscript, we report the generation of a new FAK dominant negative (FF), composed of ...
FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis
(2014)
Spindle orientation is critical for proper morphogenesis of organs and tissues as well as for the maintenance of tissue morphology. Although significant progress has been made in understanding the mechanisms linking the ...