Browsing Τμήμα Χημείας / Department of Chemistry by Author "Christoforou, Irene C."

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    • Article  

      1,2,3-Dithiazole chemistry in heterocyclic synthesis 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas; Michaelidou, Sophia S. (2006)
      The chemistry of various 5H-1,2,3-dithiazoles is investigated with emphasis on assisted ring opening and ring closure reactions leading to new heterocycles. Thus on treatment with catalytic tetraalkylammonium iodide ...
    • Article  

      3,4,5-Triarylisothiazoles via C-C coupling chemistry 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas (2007)
      The regiocontrolled preparation of triarylisothiazoles is presented. 3-Halo-5-phenylisothiazole-4-carbonitriles, 1 (hal = Cl) and 18 (hal = I), are converted into the corresponding 4-bromo derivatives 5 (3-hal = Cl) and ...
    • Article  

      New regiospecific isothiazole C-C coupling chemistry 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas (2006)
      Regioselective palladium catalysed coupling reactions are achieved in good to high yields, starting from either 3,5-dichloro- or 3,5-dibromoisothiazole-4-carbonitriles 1 and 2, providing 3-halo-5-(hetero/aryl, alkenyl and ...
    • Article  

      The preparation of dicyano-1,3,4-thiadiazole and tricyanothiazole via 1,2,3-dithiazole chemistry 

      Christoforou, Irene C.; Kalogirou, Andreas S.; Koutentis, Panayiotis Andreas (2009)
      Treatment of 1,2-bis(4-chloro-5H-1,2,3-dithiazol-5-ylidene)hydrazine 4 with benzyltriethylammonium iodide (1 equiv) affords dicyano-1,3,4-thiadiazole 3 and 5-cyano-1,3,4-thiadiazole-2-carboxamide 5 in 79 and 21% yields, ...
    • Article  

      Reactions of 1,2,3-dithiazoles with halogenated malononitriles 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas; Rees, C. W. (2002)
      Dibromomalononitrile 3a reacts with 4-chloro-1,2,3-dithiazole-5-thione 9 and monobromomalononitrile 3c reacts with 4,5-dichloro-1,2,3-dithiazolium chloride 4 (Appel salt) to give 4-chloro-5H-1,2,3-dithiazole-5-ylidenemalononitrile ...
    • Article  

      Regiospecific Suzuki coupling of 3,5-dichloroisothiazole-4-carbonitrile 

      Christoforou, Irene C.; Koutentis, Panayiotis Andreas; Rees, C. W. (2003)
      3,5-Dichloroisothiazole-4-carbonitrile 1 reacts with aryl- and methylboronic acids to give in high yields the 3-chloro-5-(aryl and methyl)-isothiazole-4-carbonitrile 2 regiospecifically. The reaction was optimized with ...
    • Article  

      Ring transformation of (4-chloro-5H-1,2,3-dithiazol-5-ylidene)acetonitriles to 3-haloisothiazole-5-carbonitriles 

      Kalogirou, Andreas S.; Christoforou, Irene C.; Ioannidou, Heraklidia A.; Manos, Manolis J.; Koutentis, Panayiotis Andreas (2014)
      Ring transformation of readily prepared (4-chloro-5H-1,2,3-dithiazol-5- ylidene)acetonitriles afford 3-haloisothiazole-5-carbonitriles in good to excellent yields. The transformation can be mediated using HBr (g), HCl (g) ...