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Suzuki-Miyaura reactions of the soluble guanylate cyclase inhibitor NS2028: A non-product specific route to C-8 substituted analogues
(2011)
Both soluble guanylate cyclase (sGC) inhibitors ODQ 1 and NS2028 2 are synthesized via improved protocols. In the former case treating 3,4-dihydroquinoxalin-2(1H)-one oxime 8, which can be prepared in two steps from ...
Synthesis, characterization, and DNA adsorption studies of ampholytic model conetworks based on cross-linked star copolymers
(2008)
Five model conetworks based on cross-linked star ampholytic copolymers were synthesized by group transfer polymerization. The ampholytic copolymers were based on two hydrophilic monomers: the positively ionizable ...
Cationic double-hydrophilic model networks: Synthesis, characterization, modeling and protein adsorption studies
(2003)
Group transfer polymerization (GTP) was used for the preparation of eight networks based on two hydrophilic monomers, 2-(dimethylamino)ethyl methacrylate (DMAEMA) and poly(ethylene glycol) methacrylate (PEGMA). Ethylene ...
Synthesis and aqueous solution characterization of catalytically active homopolymers, block copolymers and networks containing imidazole
(2000)
Imidazole-containing polymers were prepared and characterized in terms of their hydrolytic activity. Unlike similar materials synthesized in the 1960s, the polymers are of precise molecular weight and controlled structure ...
ICPBCZin: A red emitting ratiometric fluorescent indicator with nanomolar affinity for Zn2+ ions
(2008)
A new fluorescent Zn2+ indicator, namely, ICPBCZin was synthesized and the spectral profile of its free and Zn2+ bound forms was studied. The newly synthesized zinc indicator incorporates as chromophore the chromeno ...
Detosylation of 3-amino-1-tosylindole-2-carbonitriles using DBU and thiophenol
(2010)
Attempted detosylation of the 3-amino-1-(p-tosylamino)indole-2-carbonitriles 4a-c using either K2CO3 in EtOH or DBU in PhH at reflux gives unexpectedly the 3-(N-p-tosylamino)indole-2-carbonitriles 5a-c, respectively in ...
The protein effect in the structure of two ferryl-oxo intermediates at the same oxidation level in the heme copper binuclear center of cytochrome c oxidase
(2013)
Identification of the intermediates and determination of their structures in the reduction of dioxygen to water by cytochrome c oxidase (CcO) are particularly important to understanding both O2 activation and proton pumping ...
Cationic amphiphilic model networks based on symmetrical ABCBA pentablock terpolymers: Synthesis, characterization, and modelling
(2007)
Eight isomeric networks based on equimolar terpolymers were synthesized using group transfer polymerization (GTP) and were characterized in terms of their swelling properties. Two hydrophilic monomers, the nonionic methoxy ...
Regioselective hydrodehalogenation of 3,5-dihaloisothiazole-4- carbonitriles: Synthesis of 3-haloisothiazole-4-carbonitriles
(2011)
3,5-Dibromoisothiazole-4-carbonitrile 1 treated with Zn or In dust (5 equiv) and HCO2H undergoes regioselective hydrodebromination to give 3-bromoisothiazole-4-carbonitrile 3 in 70-74% yield. Similarly, 5-bromo and iodo ...
Synthesis of 2-(4H-1,2,6-thiadiazin-4-ylidene)malononitriles
(2014)
The base-free TiCl4-mediated condensation of 3,5-disubstituted-4H-1,2,6-thiadiazin-4-ones 8 with malononitrile affords 20 difficult to access (3,5-disubstituted-4H-1,2,6-thiadiazin-4-ylidene)malononitriles 7. The reaction ...