dc.contributor.author | Schultz, R. M. | en |
dc.contributor.author | Chirigos, M. A. | en |
dc.contributor.author | Pavlidis, Nicholas | en |
dc.contributor.author | Youngner, J. S. | en |
dc.creator | Schultz, R. M. | en |
dc.creator | Chirigos, M. A. | en |
dc.creator | Pavlidis, Nicholas | en |
dc.creator | Youngner, J. S. | en |
dc.date.accessioned | 2018-06-22T09:53:11Z | |
dc.date.available | 2018-06-22T09:53:11Z | |
dc.date.issued | 1978 | |
dc.identifier.uri | https://gnosis.library.ucy.ac.cy/handle/7/41699 | |
dc.description.abstract | Bru-Pel and Brucella abortus lipopolysaccharide (LPS) were tested for both macrophage activation and antitumor activity in an artificial metastasis model. Resting macrophages were rendered nonspecifically tumoricidal for MBL-2 lymphoblastic leukemia target cells by exposure to Bru-Pel at greater than or equal to 1 ng/ml of culture medium. B. abortus LPS failed to activate macrophages in vitro at all concentrations tested. Ip treatment of homozygous nude mice with Bru-Pel induced cytotoxic macrophages, indicating that Bru-Pel activated macrophages through a thymic-independent process. An artificial metastasis model was developed where single-cell suspensions of Madison 109 lung carcinoma were inoculated iv into syngeneic BALB/c mice. Bru-Pel, but not B. abortus LPS, strikingly inhibited tumor-colony formation in the lungs. Although Bru-Pel contains endotoxin, the data demonstrate that endotoxin is apparently not the active component by which Bru-Pel activates macrophages and enhances host resistance to cancer. | en |
dc.language.iso | eng | en |
dc.source | Cancer treatment reports | en |
dc.subject | Male | en |
dc.subject | Neoplasms | en |
dc.subject | Lung neoplasms | en |
dc.subject | Neoplasm metastasis | en |
dc.subject | Animals | en |
dc.subject | Mice | en |
dc.subject | Immunologic | en |
dc.subject | Cytotoxicity | en |
dc.subject | Experimental | en |
dc.subject | Macrophages | en |
dc.subject | Brucella abortus | en |
dc.subject | Brucella vaccine | en |
dc.subject | Inbred strains | en |
dc.subject | Lipopolysaccharides | en |
dc.title | Macrophage activation and antitumor activity of a Brucella abortus ether extract, Bru-Pel | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 62 | |
dc.description.issue | 11 | |
dc.description.startingpage | 1937 | |
dc.description.endingpage | 1941 | |
dc.author.faculty | Ιατρική Σχολή / Medical School | |
dc.author.department | Ιατρική Σχολή / Medical School | |
dc.type.uhtype | Article | en |
dc.contributor.orcid | Pavlidis, Nicholas [0000-0002-2195-9961] | |
dc.gnosis.orcid | 0000-0002-2195-9961 | |