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dc.contributor.authorIoachim, E.en
dc.contributor.authorCharchanti, A.en
dc.contributor.authorCharalabopoulos, K.en
dc.contributor.authorTsanou, E.en
dc.contributor.authorBriassoulis, E. Chen
dc.contributor.authorKaravasilis, V.en
dc.contributor.authorPavlidis, Nicholasen
dc.contributor.authorAgnantis, Niki J.en
dc.creatorIoachim, E.en
dc.creatorCharchanti, A.en
dc.creatorCharalabopoulos, K.en
dc.creatorTsanou, E.en
dc.creatorBriassoulis, E. Chen
dc.creatorKaravasilis, V.en
dc.creatorPavlidis, Nicholasen
dc.creatorAgnantis, Niki J.en
dc.date.accessioned2018-06-22T09:53:41Z
dc.date.available2018-06-22T09:53:41Z
dc.date.issued2002
dc.identifier.urihttps://gnosis.library.ucy.ac.cy/handle/7/41967
dc.description.abstractMicrovessel density (MVD) was analyzed for associations with clinical and pathological factors as well as with other potential known prognostic factors such as: steroid receptor content (ER, PgR), p53 and proliferation associated indices (Ki-67, PCNA). In the present study microvascular quantification was undertaken on 145 cases of breast carcinoma after immunohistochemical staining of tumor vessel, using polyclonal antibody to factor VIII related antigen. Microvessel quantification was performed at x400 magnification in the three most vascular areas of the tumors (hot spots) usually located at the periphery or growing front of the tumor. In addition, a semi-quantitative evaluation of the number of vessels per mm2 of highest intratumoral microvessel density (MVD) was performed by use of an image analysis system. Significant correlation was observed in MVD by computerized analysis and by light microscopy counting (p=0.02). Survival analysis showed increased mortality risk associated with low MVD estimated by both methods (p-0.043 and p=0.041 respectively) including node-negative and node positive subsets.). In addition low MVD was correlated with recurrence (p=0.02) and metastatic disease (p=0.0016) in the cases estimated by light microscopy. However in multivariant analysis, MVD was independently correlated with relapse-free and over patients survival. MVD was higher in lobular than in ductal cell carcinoma (p=0.015). MVD was positive correlated with estrogen receptor status (p=0.04) and inversely with tumor size (p=0.004). No association was found with tumor grade and lymph node status The results of the present study show that the MVD (determined at a microscopic level or by image analysis) correlated with better prognostic parameter maybe due to better responded to treatment. Furthermore, MVD in addition to breast cancer heterogeneity, could be reflects different phases of tumor growth.en
dc.language.isoengen
dc.sourceElectronic Journal of Pathology and Histologyen
dc.subjectHumanen
dc.subjectAgeden
dc.subjectControlled studyen
dc.subjectFemaleen
dc.subjectMajor clinical studyen
dc.subjectCancer survivalen
dc.subjectPriority journalen
dc.subjectQuantitative analysisen
dc.subjectTumor volumeen
dc.subjectMetastasisen
dc.subjectMaleen
dc.subjectCorrelation analysisen
dc.subjectConference paperen
dc.subjectImmunohistochemistryen
dc.subjectCell proliferationen
dc.subjectCancer risken
dc.subjectPcnaen
dc.subjectBreast canceren
dc.subjectBreast carcinomaen
dc.subjectRisk factoren
dc.subjectDisease associationen
dc.subjectTumor growthen
dc.subjectMicroscopyen
dc.subjectPolyclonal antibodyen
dc.subjectMedical assessmenten
dc.subjectP53en
dc.subjectMicrovasculatureen
dc.subjectAngiogenesisen
dc.subjectBlood clotting factor 8en
dc.subjectDensityen
dc.subjectEren
dc.subjectImage analysisen
dc.subjectInvasive carcinomaen
dc.subjectKi-67en
dc.subjectPgren
dc.subjectTumoren
dc.titleThe prognostic evaluation of tumor angiogenesis in invasive breast carcinomaen
dc.typeinfo:eu-repo/semantics/article
dc.description.volume8
dc.description.issue1
dc.description.startingpage10
dc.description.endingpage19
dc.author.facultyΙατρική Σχολή / Medical School
dc.type.uhtypeArticleen


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