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Transmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europe

dc.contributor.authorMoutschen, M.de
dc.contributor.authorHofstra, Laura Marije Arijeen
dc.contributor.authorSauvageot, Nicolasen
dc.contributor.authorAlbert, Janen
dc.contributor.authorAlexiev, Ivailoen
dc.contributor.authorGarcia, Federicoen
dc.contributor.authorStruck, Danielen
dc.contributor.authorVan, de Vijveren
dc.contributor.authorÅsjö, Birgittaen
dc.contributor.authorBeshkov, Danailen
dc.contributor.authorCoughlan, Suzieen
dc.contributor.authorDescamps, Dianeen
dc.contributor.authorGriskevicius, Algirdasen
dc.contributor.authorHamouda, Osamahen
dc.contributor.authorHorban, Andrzejen
dc.contributor.authorVan Kasteren, Marjoen
dc.contributor.authorKolupajeva, Tatjanaen
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorLiitsola, Kirsien
dc.contributor.authorLinka, Mareken
dc.contributor.authorMor, Ornaen
dc.contributor.authorNielsen, Clausen
dc.contributor.authorOtelea, Danen
dc.contributor.authorParaskevis, Dimitrios N.en
dc.contributor.authorParedes, Rogeren
dc.contributor.authorPoljak, Marioen
dc.contributor.authorPuchhammer-Stöckl, Elisabethen
dc.contributor.authorSönnerborg, Andersen
dc.contributor.authorStaneková, Danicaen
dc.contributor.authorStanojevic, Majaen
dc.contributor.authorVan Laethem, Kristelen
dc.contributor.authorZazzi, Maurizioen
dc.contributor.authorZidovec Lepej, Snjezanaen
dc.contributor.authorBoucher, Charles A. B.en
dc.contributor.authorSchmit, Jean-Claudeen
dc.contributor.authorWensing, Annemarie M. J.en
dc.contributor.authorPuchhammer-Stockl, E.en
dc.contributor.authorSarcletti, M.en
dc.contributor.authorSchmied, B.en
dc.contributor.authorGeit, M.en
dc.contributor.authorBalluch, G.en
dc.contributor.authorVandamme, A. M.en
dc.contributor.authorVercauteren, J.en
dc.contributor.authorDerdelinckx, I.en
dc.contributor.authorSasse, A.en
dc.contributor.authorBogaert, M.en
dc.contributor.authorCeunen, H.en
dc.contributor.authorDe Roo, A.en
dc.contributor.authorDe Wit, S.en
dc.contributor.authorEchahidi, F.en
dc.contributor.authorFransen, K.en
dc.contributor.authorGoffard, J. -Cen
dc.contributor.authorGoubau, P.en
dc.contributor.authorGoudeseune, E.en
dc.contributor.authorYombi, J. -Cen
dc.contributor.authorLacor, P.en
dc.contributor.authorLiesnard, C.en
dc.contributor.authorPierard, D.en
dc.contributor.authorRens, R.en
dc.contributor.authorSchrooten, Y.en
dc.contributor.authorVaira, D.en
dc.contributor.authorVandekerckhove, L. P. R.en
dc.contributor.authorVan, den Heuvelen
dc.contributor.authorVan, Der Guchten
dc.contributor.authorVan Ranst, M.en
dc.contributor.authorVan Wijngaerden, E.en
dc.contributor.authorVandercam, B.en
dc.contributor.authorVekemans, M.en
dc.contributor.authorVerhofstede, C.en
dc.contributor.authorClumeck, N.en
dc.contributor.authorVan Laethem, K.en
dc.contributor.authorBeshkov, Danailen
dc.contributor.authorAlexiev, Ivailoen
dc.contributor.authorLepej, S. Z.en
dc.contributor.authorBegovac, J.en
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorDemetriades, Ioannisen
dc.contributor.authorKousiappa, Ioannaen
dc.contributor.authorDemetriou, Victoria L.en
dc.contributor.authorHezka, Johanaen
dc.contributor.authorLinka, M.en
dc.contributor.authorMaly, M.en
dc.contributor.authorMachala, L.en
dc.contributor.authorNielsen, C.en
dc.contributor.authorJørgensen, L. B.en
dc.contributor.authorGerstoft, J.en
dc.contributor.authorMathiesen, L.en
dc.contributor.authorPedersen, C.en
dc.contributor.authorNielsen, H.en
dc.contributor.authorLaursen, A.en
dc.contributor.authorKvinesdal, B.en
dc.contributor.authorLiitsola, K.en
dc.contributor.authorRistola, M.en
dc.contributor.authorSuni, J.en
dc.contributor.authorSutinen, J.en
dc.contributor.authorDescamps, D.en
dc.contributor.authorAssoumou, L.en
dc.contributor.authorCastor, G.en
dc.contributor.authorGrude, M.en
dc.contributor.authorFlandre, P.en
dc.contributor.authorStorto, A.en
dc.contributor.authorHamouda, O.en
dc.contributor.authorKücherer, C.en
dc.contributor.authorBerg, T.en
dc.contributor.authorBraun, P.en
dc.contributor.authorPoggensee, G.en
dc.contributor.authorDäumer, M.en
dc.contributor.authorEberle, J.en
dc.contributor.authorHeiken, H.en
dc.contributor.authorKaiser, R.en
dc.contributor.authorKnechten, H.en
dc.contributor.authorKorn, K.en
dc.contributor.authorMüller, H.en
dc.contributor.authorNeifer, S.en
dc.contributor.authorSchmidt, B.en
dc.contributor.authorWalter, H.en
dc.contributor.authorGunsenheimer-Bartmeyer, B.en
dc.contributor.authorHarrer, T.en
dc.contributor.authorParaskevis, Dimitrios N.en
dc.contributor.authorHatzakis, Angelos E.en
dc.contributor.authorZavitsanou, Assiminaen
dc.contributor.authorVassilakis, A.en
dc.contributor.authorLazanas, Marios C.en
dc.contributor.authorChini, Maria C.en
dc.contributor.authorLioni, A.en
dc.contributor.authorSakka, V.en
dc.contributor.authorKourkounti, Sofiaen
dc.contributor.authorPaparizos, Vassilios A.en
dc.contributor.authorAntoniadou, Anastasia C.en
dc.contributor.authorPapadopoulos, Antonios I.en
dc.contributor.authorPoulakou, Garyphallia G.en
dc.contributor.authorKatsarolis, I.en
dc.contributor.authorProtopapas, K.en
dc.contributor.authorChryssos, Georgiosen
dc.contributor.authorDrimis, Stylianosen
dc.contributor.authorGargalianos, Panagiotisen
dc.contributor.authorXylomenos, Georgiosen
dc.contributor.authorLourida, G.en
dc.contributor.authorPsichogiou, Mina A.en
dc.contributor.authorDaikos, George L.en
dc.contributor.authorSipsas, N. V.en
dc.contributor.authorKontos, Athanasios N.en
dc.contributor.authorGamaletsou, M. N.en
dc.contributor.authorKoratzanis, Georgiosen
dc.contributor.authorSambatakou, H.en
dc.contributor.authorMariolis, H.en
dc.contributor.authorSkoutelis, A.en
dc.contributor.authorPapastamopoulos, V.en
dc.contributor.authorGeorgiou, O.en
dc.contributor.authorPanagopoulos, Periklisen
dc.contributor.authorMaltezos, E.en
dc.contributor.authorCoughlan, S.en
dc.contributor.authorDe Gascun, C.en
dc.contributor.authorByrne, C.en
dc.contributor.authorDuffy, M.en
dc.contributor.authorBergin, C.en
dc.contributor.authorReidy, D.en
dc.contributor.authorFarrell, G.en
dc.contributor.authorLambert, J.en
dc.contributor.authorO'Connor, E.en
dc.contributor.authorRochford, A.en
dc.contributor.authorLow, J.en
dc.contributor.authorCoakely, P.en
dc.contributor.authorO'Dea, S.en
dc.contributor.authorHall, W.en
dc.contributor.authorMor, O.en
dc.contributor.authorLevi, I.en
dc.contributor.authorChemtob, D.en
dc.contributor.authorGrossman, Z.en
dc.contributor.authorZazzi, M.en
dc.contributor.authorde Luca, A.en
dc.contributor.authorBalotta, Claudiaen
dc.contributor.authorRiva, C.en
dc.contributor.authorMussini, C.en
dc.contributor.authorCaramma, I.en
dc.contributor.authorCapetti, A.en
dc.contributor.authorColombo, M. C.en
dc.contributor.authorRossi, C.en
dc.contributor.authorPrati, F.en
dc.contributor.authorTramuto, F.en
dc.contributor.authorVitale, F.en
dc.contributor.authorCiccozzi, M.en
dc.contributor.authorAngarano, G.en
dc.contributor.authorRezza, G.en
dc.contributor.authorKolupajeva, T.en
dc.contributor.authorVasins, O.en
dc.contributor.authorGriskevicius, A.en
dc.contributor.authorLipnickiene, V.en
dc.contributor.authorSchmit, J. C.en
dc.contributor.authorStruck, D.en
dc.contributor.authorSauvageot, Nicolasen
dc.contributor.authorHemmer, R.en
dc.contributor.authorArendt, V.en
dc.contributor.authorMichaux, C.en
dc.contributor.authorStaub, T.en
dc.contributor.authorSequin-Devaux, C.en
dc.contributor.authorWensing, A. M. J.en
dc.contributor.authorBoucher, C. A. B.en
dc.contributor.authorvan, de Vijveren
dc.contributor.authorVan Kessel, A.en
dc.contributor.authorvan Bentum, P. H. M.en
dc.contributor.authorBrinkman, K.en
dc.contributor.authorConnell, B. J.en
dc.contributor.authorvan, der Endeen
dc.contributor.authorHoepelman, I. M.en
dc.contributor.authorvan Kasteren, M.en
dc.contributor.authorKuipers, M.en
dc.contributor.authorLangebeek, N.en
dc.contributor.authorRichter, C.en
dc.contributor.authorSantegoets, R. M. W. J.en
dc.contributor.authorSchrijnders-Gudde, L.en
dc.contributor.authorSchuurman, R.en
dc.contributor.authorvan, de Venen
dc.contributor.authorÅsjö, Birgittaen
dc.contributor.authorKran, A. -M B.en
dc.contributor.authorOrmaasen, V.en
dc.contributor.authorAavitsland, P.en
dc.contributor.authorHorban, A.en
dc.contributor.authorStanczak, J. J.en
dc.contributor.authorStanczak, G. P.en
dc.contributor.authorFirlag-Burkacka, E.en
dc.contributor.authorWiercinska-Drapalo, A.en
dc.contributor.authorJablonowska, E.en
dc.contributor.authorMaolepsza, E.en
dc.contributor.authorLeszczyszyn-Pynka, M.en
dc.contributor.authorSzata, W.en
dc.contributor.authorCamacho, Ricardo J.en
dc.contributor.authorPalma, C.en
dc.contributor.authorBorges, F.en
dc.contributor.authorPaixão, T.en
dc.contributor.authorDuque, V.en
dc.contributor.authorAraújo, F.en
dc.contributor.authorOtelea, D.en
dc.contributor.authorParaschiv, S.en
dc.contributor.authorTudor, A. M.en
dc.contributor.authorCernat, R.en
dc.contributor.authorChiriac, C.en
dc.contributor.authorDumitrescu, F.en
dc.contributor.authorPrisecariu, L. J.en
dc.contributor.authorStanojevic, M.en
dc.contributor.authorJevtovic, Djen
dc.contributor.authorSalemovic, D.en
dc.contributor.authorStanekova, D.en
dc.contributor.authorHabekova, M.en
dc.contributor.authorChabadová, Z.en
dc.contributor.authorDrobkova, T.en
dc.contributor.authorBukovinova, P.en
dc.contributor.authorShunnar, A.en
dc.contributor.authorTruska, P.en
dc.contributor.authorPoljak, M.en
dc.contributor.authorLunar, M.en
dc.contributor.authorBabic, Dunja Z.en
dc.contributor.authorTomazic, J.en
dc.contributor.authorVidmar, L.en
dc.contributor.authorVovko, T.en
dc.contributor.authorKarner, P.en
dc.contributor.authorGarcia, F.en
dc.contributor.authorParedes, R.en
dc.contributor.authorMonge, S.en
dc.contributor.authorMoreno, S.en
dc.contributor.authordel Amo, J.en
dc.contributor.authorAsensi, V.en
dc.contributor.authorSirvent, J. L.en
dc.contributor.authorde Mendoza, C.en
dc.contributor.authorDelgado, R.en
dc.contributor.authorGutiérrez, F.en
dc.contributor.authorBerenguer, J.en
dc.contributor.authorGarcia-Bujalance, S.en
dc.contributor.authorStella, Natalia C.en
dc.contributor.authorde, los Santosen
dc.contributor.authorBlanco, J. R.en
dc.contributor.authorDalmau, D.en
dc.contributor.authorRivero, M.en
dc.contributor.authorSegura, F.en
dc.contributor.authorElıás, Marıá Jesús Pérezen
dc.contributor.authorAlvarez, M.en
dc.contributor.authorChueca, N.en
dc.contributor.authorRodríguez-Martín, C.en
dc.contributor.authorVidal, C.en
dc.contributor.authorPalomares, J. C.en
dc.contributor.authorViciana, I.en
dc.contributor.authorViciana, P.en
dc.contributor.authorCordoba, J.en
dc.contributor.authorAguilera, A.en
dc.contributor.authorDomingo, P.en
dc.contributor.authorGalindo, M. J.en
dc.contributor.authorMiralles, C.en
dc.contributor.authordel Pozo, M. A.en
dc.contributor.authorRibera, E.en
dc.contributor.authorIribarren, J. A.en
dc.contributor.authorRuiz, L.en
dc.contributor.authorde, la Torreen
dc.contributor.authorVidal, F.en
dc.contributor.authorClotet, B.en
dc.contributor.authorAlbert, Janen
dc.contributor.authorHeidarian, A.en
dc.contributor.authorAperia-Peipke, K.en
dc.contributor.authorAxelsson, M.en
dc.contributor.authorMild, M.en
dc.contributor.authorKarlsson, A.en
dc.contributor.authorSönnerborg, A.en
dc.contributor.authorThalme, A.en
dc.contributor.authorNavér, L.en
dc.contributor.authorBratt, G.en
dc.contributor.authorKarlsson, A.en
dc.contributor.authorBlaxhult, A.en
dc.contributor.authorGisslén, M.en
dc.contributor.authorSvennerholm, B.en
dc.contributor.authorBergbrant, I.en
dc.contributor.authorBjörkman, Peren
dc.contributor.authorSäll, C.en
dc.contributor.authorMellgren, Å.en
dc.contributor.authorLindholm, A.en
dc.contributor.authorKuylenstierna, N.en
dc.contributor.authorMontelius, R.en
dc.contributor.authorAzimi, F.en
dc.contributor.authorJohansson, B.en
dc.contributor.authorCarlsson, M.en
dc.contributor.authorJohansson, E.en
dc.contributor.authorLjungberg, B.en
dc.contributor.authorEkvall, H.en
dc.contributor.authorStrand, A.en
dc.contributor.authorMäkitalo, S.en
dc.contributor.authorÖberg, S.en
dc.contributor.authorHolmblad, P.en
dc.contributor.authorHöfer, M.en
dc.contributor.authorHolmberg, H.en
dc.contributor.authorJosefson, P.en
dc.contributor.authorRyding, U.en
dc.creatorMoutschen, M.de
dc.creatorHofstra, Laura Marije Arijeen
dc.creatorSauvageot, Nicolasen
dc.creatorAlbert, Janen
dc.creatorAlexiev, Ivailoen
dc.creatorGarcia, Federicoen
dc.creatorStruck, Danielen
dc.creatorVan, de Vijveren
dc.creatorÅsjö, Birgittaen
dc.creatorBeshkov, Danailen
dc.creatorCoughlan, Suzieen
dc.creatorDescamps, Dianeen
dc.creatorGriskevicius, Algirdasen
dc.creatorHamouda, Osamahen
dc.creatorHorban, Andrzejen
dc.creatorVan Kasteren, Marjoen
dc.creatorKolupajeva, Tatjanaen
dc.creatorKostrikis, Leontios G.en
dc.creatorLiitsola, Kirsien
dc.creatorLinka, Mareken
dc.creatorMor, Ornaen
dc.creatorNielsen, Clausen
dc.creatorOtelea, Danen
dc.creatorParaskevis, Dimitrios N.en
dc.creatorParedes, Rogeren
dc.creatorPoljak, Marioen
dc.creatorPuchhammer-Stöckl, Elisabethen
dc.creatorSönnerborg, Andersen
dc.creatorStaneková, Danicaen
dc.creatorStanojevic, Majaen
dc.creatorVan Laethem, Kristelen
dc.creatorZazzi, Maurizioen
dc.creatorZidovec Lepej, Snjezanaen
dc.creatorBoucher, Charles A. B.en
dc.creatorSchmit, Jean-Claudeen
dc.creatorWensing, Annemarie M. J.en
dc.creatorPuchhammer-Stockl, E.en
dc.creatorSarcletti, M.en
dc.creatorSchmied, B.en
dc.creatorGeit, M.en
dc.creatorBalluch, G.en
dc.creatorVandamme, A. M.en
dc.creatorVercauteren, J.en
dc.creatorDerdelinckx, I.en
dc.creatorSasse, A.en
dc.creatorBogaert, M.en
dc.creatorCeunen, H.en
dc.creatorDe Roo, A.en
dc.creatorDe Wit, S.en
dc.creatorEchahidi, F.en
dc.creatorFransen, K.en
dc.creatorGoffard, J. -Cen
dc.creatorGoubau, P.en
dc.creatorGoudeseune, E.en
dc.creatorYombi, J. -Cen
dc.creatorLacor, P.en
dc.creatorLiesnard, C.en
dc.creatorPierard, D.en
dc.creatorRens, R.en
dc.creatorSchrooten, Y.en
dc.creatorVaira, D.en
dc.creatorVandekerckhove, L. P. R.en
dc.creatorVan, den Heuvelen
dc.creatorVan, Der Guchten
dc.creatorVan Ranst, M.en
dc.creatorVan Wijngaerden, E.en
dc.creatorVandercam, B.en
dc.creatorVekemans, M.en
dc.creatorVerhofstede, C.en
dc.creatorClumeck, N.en
dc.creatorVan Laethem, K.en
dc.creatorBeshkov, Danailen
dc.creatorAlexiev, Ivailoen
dc.creatorLepej, S. Z.en
dc.creatorBegovac, J.en
dc.creatorKostrikis, Leontios G.en
dc.creatorDemetriades, Ioannisen
dc.creatorKousiappa, Ioannaen
dc.creatorDemetriou, Victoria L.en
dc.creatorHezka, Johanaen
dc.creatorLinka, M.en
dc.creatorMaly, M.en
dc.creatorMachala, L.en
dc.creatorNielsen, C.en
dc.creatorJørgensen, L. B.en
dc.creatorGerstoft, J.en
dc.creatorMathiesen, L.en
dc.creatorPedersen, C.en
dc.creatorNielsen, H.en
dc.creatorLaursen, A.en
dc.creatorKvinesdal, B.en
dc.creatorLiitsola, K.en
dc.creatorRistola, M.en
dc.creatorSuni, J.en
dc.creatorSutinen, J.en
dc.creatorDescamps, D.en
dc.creatorAssoumou, L.en
dc.creatorCastor, G.en
dc.creatorGrude, M.en
dc.creatorFlandre, P.en
dc.creatorStorto, A.en
dc.creatorHamouda, O.en
dc.creatorKücherer, C.en
dc.creatorBerg, T.en
dc.creatorBraun, P.en
dc.creatorPoggensee, G.en
dc.creatorDäumer, M.en
dc.creatorEberle, J.en
dc.creatorHeiken, H.en
dc.creatorKaiser, R.en
dc.creatorKnechten, H.en
dc.creatorKorn, K.en
dc.creatorMüller, H.en
dc.creatorNeifer, S.en
dc.creatorSchmidt, B.en
dc.creatorWalter, H.en
dc.creatorGunsenheimer-Bartmeyer, B.en
dc.creatorHarrer, T.en
dc.creatorParaskevis, Dimitrios N.en
dc.creatorHatzakis, Angelos E.en
dc.creatorZavitsanou, Assiminaen
dc.creatorVassilakis, A.en
dc.creatorLazanas, Marios C.en
dc.creatorChini, Maria C.en
dc.creatorLioni, A.en
dc.creatorSakka, V.en
dc.creatorKourkounti, Sofiaen
dc.creatorPaparizos, Vassilios A.en
dc.creatorAntoniadou, Anastasia C.en
dc.creatorPapadopoulos, Antonios I.en
dc.creatorPoulakou, Garyphallia G.en
dc.creatorKatsarolis, I.en
dc.creatorProtopapas, K.en
dc.creatorChryssos, Georgiosen
dc.creatorDrimis, Stylianosen
dc.creatorGargalianos, Panagiotisen
dc.creatorXylomenos, Georgiosen
dc.creatorLourida, G.en
dc.creatorPsichogiou, Mina A.en
dc.creatorDaikos, George L.en
dc.creatorSipsas, N. V.en
dc.creatorKontos, Athanasios N.en
dc.creatorGamaletsou, M. N.en
dc.creatorKoratzanis, Georgiosen
dc.creatorSambatakou, H.en
dc.creatorMariolis, H.en
dc.creatorSkoutelis, A.en
dc.creatorPapastamopoulos, V.en
dc.creatorGeorgiou, O.en
dc.creatorPanagopoulos, Periklisen
dc.creatorMaltezos, E.en
dc.creatorCoughlan, S.en
dc.creatorDe Gascun, C.en
dc.creatorByrne, C.en
dc.creatorDuffy, M.en
dc.creatorBergin, C.en
dc.creatorReidy, D.en
dc.creatorFarrell, G.en
dc.creatorLambert, J.en
dc.creatorO'Connor, E.en
dc.creatorRochford, A.en
dc.creatorLow, J.en
dc.creatorCoakely, P.en
dc.creatorO'Dea, S.en
dc.creatorHall, W.en
dc.creatorMor, O.en
dc.creatorLevi, I.en
dc.creatorChemtob, D.en
dc.creatorGrossman, Z.en
dc.creatorZazzi, M.en
dc.creatorde Luca, A.en
dc.creatorBalotta, Claudiaen
dc.creatorRiva, C.en
dc.creatorMussini, C.en
dc.creatorCaramma, I.en
dc.creatorCapetti, A.en
dc.creatorColombo, M. C.en
dc.creatorRossi, C.en
dc.creatorPrati, F.en
dc.creatorTramuto, F.en
dc.creatorVitale, F.en
dc.creatorCiccozzi, M.en
dc.creatorAngarano, G.en
dc.creatorRezza, G.en
dc.creatorKolupajeva, T.en
dc.creatorVasins, O.en
dc.creatorGriskevicius, A.en
dc.creatorLipnickiene, V.en
dc.creatorSchmit, J. C.en
dc.creatorStruck, D.en
dc.creatorSauvageot, Nicolasen
dc.creatorHemmer, R.en
dc.creatorArendt, V.en
dc.creatorMichaux, C.en
dc.creatorStaub, T.en
dc.creatorSequin-Devaux, C.en
dc.creatorWensing, A. M. J.en
dc.creatorBoucher, C. A. B.en
dc.creatorvan, de Vijveren
dc.creatorvan Kessel, A.en
dc.creatorvan Bentum, P. H. M.en
dc.creatorBrinkman, K.en
dc.creatorConnell, B. J.en
dc.creatorvan, der Endeen
dc.creatorHoepelman, I. M.en
dc.creatorvan Kasteren, M.en
dc.creatorKuipers, M.en
dc.creatorLangebeek, N.en
dc.creatorRichter, C.en
dc.creatorSantegoets, R. M. W. J.en
dc.creatorSchrijnders-Gudde, L.en
dc.creatorSchuurman, R.en
dc.creatorvan, de Venen
dc.creatorÅsjö, Birgittaen
dc.creatorKran, A. -M B.en
dc.creatorOrmaasen, V.en
dc.creatorAavitsland, P.en
dc.creatorHorban, A.en
dc.creatorStanczak, J. J.en
dc.creatorStanczak, G. P.en
dc.creatorFirlag-Burkacka, E.en
dc.creatorWiercinska-Drapalo, A.en
dc.creatorJablonowska, E.en
dc.creatorMaolepsza, E.en
dc.creatorLeszczyszyn-Pynka, M.en
dc.creatorSzata, W.en
dc.creatorCamacho, Ricardo J.en
dc.creatorPalma, C.en
dc.creatorBorges, F.en
dc.creatorPaixão, T.en
dc.creatorDuque, V.en
dc.creatorAraújo, F.en
dc.creatorOtelea, D.en
dc.creatorParaschiv, S.en
dc.creatorTudor, A. M.en
dc.creatorCernat, R.en
dc.creatorChiriac, C.en
dc.creatorDumitrescu, F.en
dc.creatorPrisecariu, L. J.en
dc.creatorStanojevic, M.en
dc.creatorJevtovic, Djen
dc.creatorSalemovic, D.en
dc.creatorStanekova, D.en
dc.creatorHabekova, M.en
dc.creatorChabadová, Z.en
dc.creatorDrobkova, T.en
dc.creatorBukovinova, P.en
dc.creatorShunnar, A.en
dc.creatorTruska, P.en
dc.creatorPoljak, M.en
dc.creatorLunar, M.en
dc.creatorBabic, Dunja Z.en
dc.creatorTomazic, J.en
dc.creatorVidmar, L.en
dc.creatorVovko, T.en
dc.creatorKarner, P.en
dc.creatorGarcia, F.en
dc.creatorParedes, R.en
dc.creatorMonge, S.en
dc.creatorMoreno, S.en
dc.creatordel Amo, J.en
dc.creatorAsensi, V.en
dc.creatorSirvent, J. L.en
dc.creatorde Mendoza, C.en
dc.creatorDelgado, R.en
dc.creatorGutiérrez, F.en
dc.creatorBerenguer, J.en
dc.creatorGarcia-Bujalance, S.en
dc.creatorStella, Natalia C.en
dc.creatorde, los Santosen
dc.creatorBlanco, J. R.en
dc.creatorDalmau, D.en
dc.creatorRivero, M.en
dc.creatorSegura, F.en
dc.creatorElıás, Marıá Jesús Pérezen
dc.creatorAlvarez, M.en
dc.creatorChueca, N.en
dc.creatorRodríguez-Martín, C.en
dc.creatorVidal, C.en
dc.creatorPalomares, J. C.en
dc.creatorViciana, I.en
dc.creatorViciana, P.en
dc.creatorCordoba, J.en
dc.creatorAguilera, A.en
dc.creatorDomingo, P.en
dc.creatorGalindo, M. J.en
dc.creatorMiralles, C.en
dc.creatordel Pozo, M. A.en
dc.creatorRibera, E.en
dc.creatorIribarren, J. A.en
dc.creatorRuiz, L.en
dc.creatorde, la Torreen
dc.creatorVidal, F.en
dc.creatorClotet, B.en
dc.creatorAlbert, Janen
dc.creatorHeidarian, A.en
dc.creatorAperia-Peipke, K.en
dc.creatorAxelsson, M.en
dc.creatorMild, M.en
dc.creatorKarlsson, A.en
dc.creatorSönnerborg, A.en
dc.creatorThalme, A.en
dc.creatorNavér, L.en
dc.creatorBratt, G.en
dc.creatorKarlsson, A.en
dc.creatorBlaxhult, A.en
dc.creatorGisslén, M.en
dc.creatorSvennerholm, B.en
dc.creatorBergbrant, I.en
dc.creatorBjörkman, Peren
dc.creatorSäll, C.en
dc.creatorMellgren, Å.en
dc.creatorLindholm, A.en
dc.creatorKuylenstierna, N.en
dc.creatorMontelius, R.en
dc.creatorAzimi, F.en
dc.creatorJohansson, B.en
dc.creatorCarlsson, M.en
dc.creatorJohansson, E.en
dc.creatorLjungberg, B.en
dc.creatorEkvall, H.en
dc.creatorStrand, A.en
dc.creatorMäkitalo, S.en
dc.creatorÖberg, S.en
dc.creatorHolmblad, P.en
dc.creatorHöfer, M.en
dc.creatorHolmberg, H.en
dc.creatorJosefson, P.en
dc.creatorRyding, U.en
dc.date.accessioned2019-11-04T12:50:43Z
dc.date.available2019-11-04T12:50:43Z
dc.date.issued2015
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53130
dc.source.urihttps://nls.ldls.org.uk/welcome.html?lsidyva01fc774
dc.subjectCommunicable diseasesen
dc.titleTransmission of HIV Drug Resistance and the Predicted Effect on Current First-line Regimens in Europeen
dc.typeinfo:eu-repo/semantics/article
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>ID: 740en
dc.description.notesIn: Clinical infectious diseases volume 62 issue 5 page 655.en
dc.description.notesSummary: Transmitted human immunodeficiency virus drug resistance in Europe is stable at around 8%. The impact of baseline mutation patterns on susceptibility to antiretroviral drugs should be addressed using clinical guidelines. The impact on baseline susceptibility is largest for nonnucleoside reverse transcriptase inhibitors.en
dc.description.notesSummary: Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001.Methods. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)–infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0.Results. The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%–9.5%) in 2008–2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones.Conclusions. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected.</p>en
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]
dc.contributor.orcidParaskevis, Dimitrios [0000-0001-6167-7152]
dc.gnosis.orcid0000-0002-5340-7109
dc.gnosis.orcid0000-0001-6167-7152


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