Transmission of HIV drug resistance and the predicted effect on current first-line regimens in Europe

Moutschen, M.; Hofstra, Laura Marije Arije; Sauvageot, Nicolas; Albert, Jan; Alexiev, Ivailo; Garcia, F.; Struck, D.; Van De Vijver, D. A. M. C.; Åsjö, Birgitta; Beshkov, Danail; Coughlan, S.; Descamps, D.; Griskevicius, A.; Hamouda, O.; Horban, A.; Van Kasteren, M.; Kolupajeva, T.; Kostrikis, Leontios G.; Liitsola, K.; Linka, M.; Mor, O.; Nielsen, C.; Otelea, D.; Paraskevis, Dimitrios N.; Paredes, R.; Poljak, M.; Puchhammer-Stöckl, E.; Sönnerborg, A.; Staneková, D.; Stanojevic, M.; Van Laethem, K.; Zazzi, M.; Lepej, S. Z.; Boucher, C. A. B.; Schmit, J. -C; Wensing, A. M. J.; Puchhammer-Stockl, E.; Sarcletti, M.; Schmied, B.; Geit, M.; Balluch, G.; Vandamme, A. M.; Vercauteren, J.; Derdelinckx, I.; Sasse, A.; Bogaert, M.; Ceunen, H.; De Roo, A.; De Wit, S.; Echahidi, F.; Fransen, K.; Goffard, J. -C; Goubau, P.; Goudeseune, E.; Yombi, J. -C; Lacor, P.; Liesnard, C.; Pierard, D.; Rens, R.; Schrooten, Y.; Vaira, D.; Vandekerckhove, L. P. R.; Van Den Heuvel, A.; Van Der Gucht, B.; Van Ranst, M.; Van Wijngaerden, E.; Vandercam, B.; Vekemans, M.; Verhofstede, C.; Clumeck, N.; Van Laethem, K.; Beshkov, Danail; Alexiev, Ivailo; Lepej, S. Z.; Begovac, J.; Kostrikis, Leontios G.; Demetriades, Ioannis; Kousiappa, Ioanna; Demetriou, Victoria L.; Hezka, Johana; Linka, M.; Maly, M.; Machala, L.; Nielsen, C.; Jørgensen, L. B.; Gerstoft, J.; Mathiesen, L.; Pedersen, C.; Nielsen, H.; Laursen, A.; Kvinesdal, B.; Liitsola, K.; Ristola, M.; Suni, J.; Sutinen, J.; Descamps, D.; Assoumou, L.; Castor, G.; Grude, M.; Flandre, P.; Storto, A.; Hamouda, O.; Kücherer, C.; Berg, T.; Braun, P.; Poggensee, G.; Däumer, M.; Eberle, J.; Heiken, H.; Kaiser, R.; Knechten, H.; Korn, K.; Müller, H.; Neifer, S.; Schmidt, B.; Walter, H.; Gunsenheimer-Bartmeyer, B.; Harrer, T.; Paraskevis, Dimitrios N.; Hatzakis, Angelos E.; Zavitsanou, Assimina; Vassilakis, A.; Lazanas, Marios C.; Chini, Maria C.; Lioni, A.; Sakka, V.; Kourkounti, Sofia; Paparizos, Vassilios A.; Antoniadou, Anastasia C.; Papadopoulos, Antonios I.; Poulakou, Garyphallia G.; Katsarolis, I.; Protopapas, K.; Chryssos, Georgios; Drimis, Stylianos; Gargalianos, Panagiotis; Xylomenos, Georgios; Lourida, G.; Psichogiou, Mina A.; Daikos, George L.; Sipsas, N. V.; Kontos, Athanasios N.; Gamaletsou, M. N.; Koratzanis, Georgios; Sambatakou, E.; Mariolis, H.; Skoutelis, A.; Papastamopoulos, V.; Georgiou, O.; Panagopoulos, Periklis; Maltezos, E.; Coughlan, S.; De Gascun, C.; Byrne, C.; Duffy, M.; Bergin, C.; Reidy, D.; Farrell, G.; Lambert, J.; O'Connor, E.; Rochford, A.; Low, J.; Coakely, P.; O'Dea, S.; Hall, W.; Mor, O.; Levi, I.; Chemtob, D.; Grossman, Z.; Zazzi, M.; De Luca, A.; Balotta, Claudia; Riva, C.; Mussini, C.; Caramma, I.; Capetti, A.; Colombo, M. C.; Rossi, C.; Prati, F.; Tramuto, F.; Vitale, F.; Ciccozzi, M.; Angarano, G.; Rezza, G.; Kolupajeva, T.; Kolupajeva, T.; Vasins, O.; Griskevicius, A.; Lipnickiene, V.; Schmit, J. C.; Struck, D.; Sauvageot, Nicolas; Hemmer, R.; Arendt, V.; Michaux, C.; Staub, T.; Sequin-Devaux, C.; Wensing, A. M. J.; Boucher, C. A. B.; Van Kessel, A.; Van Bentum, P. H. M.; Brinkman, K.; Connell, B. J.; Van Der Ende, M. E.; Hoepelman, I. M.; Van Kasteren, M.; Kuipers, M.; Langebeek, N.; Richter, C.; Santegoets, R. M. W. J.; Schrijnders-Gudde, L.; Schuurman, R.; Van De Ven, B. J. M.; Åsjö, Birgitta; Kran, A. -M B.; Ormaasen, V.; Aavitsland, P.; Horban, A.; Stanczak, J. J.; Stanczak, G. P.; Firlag-Burkacka, E.; Wiercinska-Drapalo, A.; Jablonowska, E.; Maolepsza, E.; Leszczyszyn-Pynka, M.; Szata, W.; Camacho, Ricardo J.; Palma, C.; Borges, F.; Paixão, T.; Duque, V.; Araújo, F.; Otelea, D.; Paraschiv, S.; Tudor, A. M.; Cernat, R.; Chiriac, C.; Dumitrescu, F.; Prisecariu, L. J.; Jevtovic, Dj; Salemovic, D.; Stanekova, D.; Habekova, M.; Chabadová, Z.; Drobkova, T.; Bukovinova, P.; Shunnar, A.; Truska, P.; Poljak, M.; Lunar, M.; Babic, Dunja Z.; Tomazic, J.; Vidmar, L.; Vovko, T.; Karner, P.; Garcia, F.; Paredes, R.; Monge, S.; Moreno, S.; Del Amo, J.; Asensi, V.; Sirvent, J. L.; De Mendoza, C.; Delgado, R.; Gutiérrez, F.; Berenguer, J.; Garcia-Bujalance, S.; Stella, Natalia C.; Blanco, J. R.; Dalmau, D.; Rivero, M.; Segura, F.; Elıás, Marıá Jesús Pérez; Alvarez, M.; Chueca, N.; Rodríguez-Martín, C.; Vidal, C.; Palomares, J. C.; Viciana, I.; Viciana, P.; Cordoba, J.; Aguilera, A.; Domingo, P.; Galindo, M. J.; Miralles, C.; Del Pozo, M. A.; Ribera, E.; Iribarren, J. A.; Ruiz, L.; De La Torre, J.; Vidal, F.; Clotet, B.; Albert, Jan; Heidarian, A.; Aperia-Peipke, K.; Axelsson, M.; Mild, M.; Karlsson, A.; Sönnerborg, A.; Thalme, A.; Navér, L.; Bratt, G.; Karlsson, A.; Blaxhult, A.; Gisslén, M.; Svennerholm, B.; Bergbrant, I.; Björkman, Per; Säll, C.; Mellgren, Å.; Lindholm, A.; Kuylenstierna, N.; Montelius, R.; Azimi, F.; Johansson, B.; Carlsson, M.; Johansson, E.; Ljungberg, B.; Ekvall, H.; Strand, A.; Mäkitalo, S.; Öberg, S.; Holmblad, P.; Höfer, M.; Holmberg, H.; Josefson, P.; Ryding, U.; De Los Santos, I.

doi:10.1093/cid/civ963

Article

Date

2016

Author

Moutschen, M.
Hofstra, Laura Marije Arije
Sauvageot, Nicolas
Albert, Jan
Alexiev, Ivailo
Garcia, F.
Struck, D.
Van De Vijver, D. A. M. C.
Åsjö, Birgitta
Beshkov, Danail
Coughlan, S.
Descamps, D.
Griskevicius, A.
Hamouda, O.
Horban, A.
Van Kasteren, M.
Kolupajeva, T.

Kostrikis, Leontios G.
Liitsola, K.
Linka, M.
Mor, O.
Nielsen, C.
Otelea, D.
Paraskevis, Dimitrios N.
Paredes, R.
Poljak, M.
Puchhammer-Stöckl, E.
Sönnerborg, A.
Staneková, D.
Stanojevic, M.
Van Laethem, K.
Zazzi, M.
Lepej, S. Z.
Boucher, C. A. B.
Schmit, J. -C
Wensing, A. M. J.
Puchhammer-Stockl, E.
Sarcletti, M.
Schmied, B.
Geit, M.
Balluch, G.
Vandamme, A. M.
Vercauteren, J.
Derdelinckx, I.
Sasse, A.
Bogaert, M.
Ceunen, H.
De Roo, A.
De Wit, S.
Echahidi, F.
Fransen, K.
Goffard, J. -C
Goubau, P.
Goudeseune, E.
Yombi, J. -C
Lacor, P.
Liesnard, C.
Pierard, D.
Rens, R.
Schrooten, Y.
Vaira, D.
Vandekerckhove, L. P. R.
Van Den Heuvel, A.
Van Der Gucht, B.
Van Ranst, M.
Van Wijngaerden, E.
Vandercam, B.
Vekemans, M.
Verhofstede, C.
Clumeck, N.
Van Laethem, K.
Beshkov, Danail
Alexiev, Ivailo
Lepej, S. Z.
Begovac, J.

Kostrikis, Leontios G.
Demetriades, Ioannis
Kousiappa, Ioanna
Demetriou, Victoria L.
Hezka, Johana
Linka, M.
Maly, M.
Machala, L.
Nielsen, C.
Jørgensen, L. B.
Gerstoft, J.
Mathiesen, L.
Pedersen, C.
Nielsen, H.
Laursen, A.
Kvinesdal, B.
Liitsola, K.
Ristola, M.
Suni, J.
Sutinen, J.
Descamps, D.
Assoumou, L.
Castor, G.
Grude, M.
Flandre, P.
Storto, A.
Hamouda, O.
Kücherer, C.
Berg, T.
Braun, P.
Poggensee, G.
Däumer, M.
Eberle, J.
Heiken, H.
Kaiser, R.
Knechten, H.
Korn, K.
Müller, H.
Neifer, S.
Schmidt, B.
Walter, H.
Gunsenheimer-Bartmeyer, B.
Harrer, T.
Paraskevis, Dimitrios N.
Hatzakis, Angelos E.
Zavitsanou, Assimina
Vassilakis, A.
Lazanas, Marios C.
Chini, Maria C.
Lioni, A.
Sakka, V.
Kourkounti, Sofia
Paparizos, Vassilios A.
Antoniadou, Anastasia C.
Papadopoulos, Antonios I.
Poulakou, Garyphallia G.
Katsarolis, I.
Protopapas, K.
Chryssos, Georgios
Drimis, Stylianos
Gargalianos, Panagiotis
Xylomenos, Georgios
Lourida, G.
Psichogiou, Mina A.
Daikos, George L.
Sipsas, N. V.
Kontos, Athanasios N.
Gamaletsou, M. N.
Koratzanis, Georgios
Sambatakou, E.
Mariolis, H.
Skoutelis, A.
Papastamopoulos, V.
Georgiou, O.
Panagopoulos, Periklis
Maltezos, E.
Coughlan, S.
De Gascun, C.
Byrne, C.
Duffy, M.
Bergin, C.
Reidy, D.
Farrell, G.
Lambert, J.
O'Connor, E.
Rochford, A.
Low, J.
Coakely, P.
O'Dea, S.
Hall, W.
Mor, O.
Levi, I.
Chemtob, D.
Grossman, Z.
Zazzi, M.
De Luca, A.
Balotta, Claudia
Riva, C.
Mussini, C.
Caramma, I.
Capetti, A.
Colombo, M. C.
Rossi, C.
Prati, F.
Tramuto, F.
Vitale, F.
Ciccozzi, M.
Angarano, G.
Rezza, G.
Kolupajeva, T.
Kolupajeva, T.
Vasins, O.
Griskevicius, A.
Lipnickiene, V.
Schmit, J. C.
Struck, D.
Sauvageot, Nicolas
Hemmer, R.
Arendt, V.
Michaux, C.
Staub, T.
Sequin-Devaux, C.
Wensing, A. M. J.
Boucher, C. A. B.
Van Kessel, A.
Van Bentum, P. H. M.
Brinkman, K.
Connell, B. J.
Van Der Ende, M. E.
Hoepelman, I. M.
Van Kasteren, M.
Kuipers, M.
Langebeek, N.
Richter, C.
Santegoets, R. M. W. J.
Schrijnders-Gudde, L.
Schuurman, R.
Van De Ven, B. J. M.
Åsjö, Birgitta
Kran, A. -M B.
Ormaasen, V.
Aavitsland, P.
Horban, A.
Stanczak, J. J.
Stanczak, G. P.
Firlag-Burkacka, E.
Wiercinska-Drapalo, A.
Jablonowska, E.
Maolepsza, E.
Leszczyszyn-Pynka, M.
Szata, W.
Camacho, Ricardo J.
Palma, C.
Borges, F.
Paixão, T.
Duque, V.
Araújo, F.
Otelea, D.
Paraschiv, S.
Tudor, A. M.
Cernat, R.
Chiriac, C.
Dumitrescu, F.
Prisecariu, L. J.
Jevtovic, Dj
Salemovic, D.
Stanekova, D.
Habekova, M.
Chabadová, Z.
Drobkova, T.
Bukovinova, P.
Shunnar, A.
Truska, P.
Poljak, M.
Lunar, M.
Babic, Dunja Z.
Tomazic, J.
Vidmar, L.
Vovko, T.
Karner, P.
Garcia, F.
Paredes, R.
Monge, S.
Moreno, S.
Del Amo, J.
Asensi, V.
Sirvent, J. L.
De Mendoza, C.
Delgado, R.
Gutiérrez, F.
Berenguer, J.
Garcia-Bujalance, S.
Stella, Natalia C.
Blanco, J. R.
Dalmau, D.
Rivero, M.
Segura, F.
Elıás, Marıá Jesús Pérez
Alvarez, M.
Chueca, N.
Rodríguez-Martín, C.
Vidal, C.
Palomares, J. C.
Viciana, I.
Viciana, P.
Cordoba, J.
Aguilera, A.
Domingo, P.
Galindo, M. J.
Miralles, C.
Del Pozo, M. A.
Ribera, E.
Iribarren, J. A.
Ruiz, L.
De La Torre, J.
Vidal, F.
Clotet, B.
Albert, Jan
Heidarian, A.
Aperia-Peipke, K.
Axelsson, M.
Mild, M.
Karlsson, A.
Sönnerborg, A.
Thalme, A.
Navér, L.
Bratt, G.
Karlsson, A.
Blaxhult, A.
Gisslén, M.
Svennerholm, B.
Bergbrant, I.
Björkman, Per
Säll, C.
Mellgren, Å.
Lindholm, A.
Kuylenstierna, N.
Montelius, R.
Azimi, F.
Johansson, B.
Carlsson, M.
Johansson, E.
Ljungberg, B.
Ekvall, H.
Strand, A.
Mäkitalo, S.
Öberg, S.
Holmblad, P.
Höfer, M.
Holmberg, H.
Josefson, P.
Ryding, U.
De Los Santos, I.

ISSN

1058-4838

Source

Clinical Infectious Diseases

Volume

Pages

655-663

Google Scholar check

Keyword(s):

Europe

human

Humans

adult

female

male

Article

Microbial Sensitivity Tests

anti human immunodeficiency virus agent

Anti-HIV Agents

drug effects

Human immunodeficiency virus 1

HIV-1

antiretrovirus agent

emtricitabine

Human immunodeficiency virus infected patient

Human immunodeficiency virus 1 infection

nevirapine

Reverse Transcriptase Inhibitors

Drug Resistance, Viral

RNA directed DNA polymerase inhibitor

Antiretroviral therapy

abacavir plus lamivudine

antiviral susceptibility

darunavir

HIV Protease Inhibitors

Human immunodeficiency virus proteinase inhibitor

microbial sensitivity test

transmitted drug resistance

Metadata

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Abstract

Background. Numerous studies have shown that baseline drug resistance patterns may influence the outcome of antiretroviral therapy. Therefore, guidelines recommend drug resistance testing to guide the choice of initial regimen. In addition to optimizing individual patient management, these baseline resistance data enable transmitted drug resistance (TDR) to be surveyed for public health purposes. The SPREAD program systematically collects data to gain insight into TDR occurring in Europe since 2001. Methods. Demographic, clinical, and virological data from 4140 antiretroviral-naive human immunodeficiency virus (HIV)-infected individuals from 26 countries who were newly diagnosed between 2008 and 2010 were analyzed. Evidence of TDR was defined using the WHO list for surveillance of drug resistance mutations. Prevalence of TDR was assessed over time by comparing the results to SPREAD data from 2002 to 2007. Baseline susceptibility to antiretroviral drugs was predicted using the Stanford HIVdb program version 7.0. Results. The overall prevalence of TDR did not change significantly over time and was 8.3% (95% confidence interval, 7.2%-9.5%) in 2008-2010. The most frequent indicators of TDR were nucleoside reverse transcriptase inhibitor (NRTI) mutations (4.5%), followed by nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations (2.9%) and protease inhibitor mutations (2.0%). Baseline mutations were most predictive of reduced susceptibility to initial NNRTI-based regimens: 4.5% and 6.5% of patient isolates were predicted to have resistance to regimens containing efavirenz or rilpivirine, respectively, independent of current NRTI backbones. Conclusions. Although TDR was highest for NRTIs, the impact of baseline drug resistance patterns on susceptibility was largest for NNRTIs. The prevalence of TDR assessed by epidemiological surveys does not clearly indicate to what degree susceptibility to different drug classes is affected. © The Author 2015.