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dc.contributor.authorIoannidis, J. P. A.en
dc.contributor.authorRosenberg, P. S.en
dc.contributor.authorGoedert, J. J.en
dc.contributor.authorAshton, L. J.en
dc.contributor.authorBenfield, T. L.en
dc.contributor.authorBuchbinder, S. P.en
dc.contributor.authorCoutinho, R. A.en
dc.contributor.authorEugen-Olsen, J.en
dc.contributor.authorGallart, T.en
dc.contributor.authorKatzenstein, T. L.en
dc.contributor.authorKostrikis, Leontios G.en
dc.contributor.authorKuipers, H.en
dc.contributor.authorLouie, L. G.en
dc.contributor.authorMallal, S. A.en
dc.contributor.authorMargolick, J. B.en
dc.contributor.authorMartinez, O. P.en
dc.contributor.authorMeyer, L.en
dc.contributor.authorMichael, N. L.en
dc.contributor.authorOperskalski, E.en
dc.contributor.authorPantaleo, G.en
dc.contributor.authorRizzardi, G. P.en
dc.contributor.authorSchuitemaker, H.en
dc.contributor.authorSheppard, H. W.en
dc.contributor.authorStewart, G. J.en
dc.contributor.authorTheodorou, I. D.en
dc.contributor.authorUllum, H.en
dc.contributor.authorVicenzi, E.en
dc.contributor.authorVlahov, D.en
dc.contributor.authorWilkinson, D.en
dc.contributor.authorWorkman, C.en
dc.contributor.authorZagury, J. -Fen
dc.contributor.authorO'Brien, T. R.en
dc.creatorIoannidis, J. P. A.en
dc.creatorRosenberg, P. S.en
dc.creatorGoedert, J. J.en
dc.creatorAshton, L. J.en
dc.creatorBenfield, T. L.en
dc.creatorBuchbinder, S. P.en
dc.creatorCoutinho, R. A.en
dc.creatorEugen-Olsen, J.en
dc.creatorGallart, T.en
dc.creatorKatzenstein, T. L.en
dc.creatorKostrikis, Leontios G.en
dc.creatorKuipers, H.en
dc.creatorLouie, L. G.en
dc.creatorMallal, S. A.en
dc.creatorMargolick, J. B.en
dc.creatorMartinez, O. P.en
dc.creatorMeyer, L.en
dc.creatorMichael, N. L.en
dc.creatorOperskalski, E.en
dc.creatorPantaleo, G.en
dc.creatorRizzardi, G. P.en
dc.creatorSchuitemaker, H.en
dc.creatorSheppard, H. W.en
dc.creatorStewart, G. J.en
dc.creatorTheodorou, I. D.en
dc.creatorUllum, H.en
dc.creatorVicenzi, E.en
dc.creatorVlahov, D.en
dc.creatorWilkinson, D.en
dc.creatorWorkman, C.en
dc.creatorZagury, J. -Fen
dc.creatorO'Brien, T. R.en
dc.description.abstractBackground: Studies relating certain chemokine and chemokine receptor gene alleles with the outcome of HIV-1 infection have yielded inconsistent results. Objective: To examine postulated associations of genetic alleles with HIV-1 disease progression. Design: Meta-analysis of individual-patient data. Setting: 19 prospective cohort studies and case-control studies from the United States, Europe, and Australia. Patients: Patients with HIV-1 infection who were of European or African descent. Measurements: Time to AIDS, death, and death after AIDS and HIV-1 RNA level at study entry or soon after seroconversion. Data were combined with fixed-effects and random-effects models. Results: Both the CCR5-Δ32 and CCR2-64I alleles were associated with a decreased risk for progression to AIDS (relative hazard among seroconverters, 0.74 and 0.76, respectivelyen
dc.description.abstractP = 0.01 for both), a decreased risk for death (relative hazard among seroconverters, 0.64 and 0.74en
dc.description.abstractP < 0.05 for both), and lower HIV-1 RNA levels after seroconversion (difference, -0.18 log10 copies/mL and -0.14 log10 copies/mLen
dc.description.abstractP < 0.05 for both). Having the CCR5-Δ32 or CCR2-64I allele had no clear protective effect on the risk for death after development of AIDS. The results were consistent between seroconverters and seroprevalent patients. In contrast, SDF-1 3′A homozygotes showed no decreased risk for AIDS (relative hazard for seroconverters and seroprevalent patients, 0.99 and 1.03, respectively), death (relative hazard, 0.97 and 1.00), or death after development of AIDS (relative hazard, 0.81 and 0.97en
dc.description.abstractP < 0.5 for all). Conclusions: The CCR5-Δ32 and CCR2-64I alleles had a strong protective effect on progression of HIV-1 infection, but SDF-1 3′A homozygosity carried no such protection.en
dc.sourceAnnals of Internal Medicineen
dc.subjectregression analysisen
dc.subjectmajor clinical studyen
dc.subjectDisease Progressionen
dc.subjectpriority journalen
dc.subjectclinical trialen
dc.subjectHuman immunodeficiency virus infectionen
dc.subjectdisease courseen
dc.subjectmeta analysisen
dc.subjectrisk assessmenten
dc.subjectHIV Infectionsen
dc.subjectdisease associationen
dc.subjectdisease activityen
dc.subjectAcquired Immunodeficiency Syndromeen
dc.subjectproportional hazards modelen
dc.subjectProportional Hazards Modelsen
dc.subjectgenetic risken
dc.subjectHuman immunodeficiency virus 1en
dc.subjectacquired immune deficiency syndromeen
dc.subjectchemokine receptoren
dc.subjectReceptors, Chemokineen
dc.subjectchemokine receptor CCR2en
dc.subjectchemokine receptor CCR5en
dc.subjectmonocyte chemoattractant protein 1 receptoren
dc.subjectReceptors, CCR5en
dc.subjectalpha chemokineen
dc.subjectChemokines, CXCen
dc.subjectstromal cell derived factor 1en
dc.titleEffects of CCR5-Δ32, CCR2-64I, and SDF-1 3′ a alleles on HIV-1 disease progression: An international meta-analysis of individual-patient dataen
dc.description.endingpage795Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied SciencesΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.description.notes<p>Cited By :238</p>en
dc.contributor.orcidKostrikis, Leontios G. [0000-0002-5340-7109]

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