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Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2

dc.contributor.authorKirmizis, Antonisen
dc.contributor.authorSantos-Rosa, H.en
dc.contributor.authorPenkett, C. J.en
dc.contributor.authorSinger, M. A.en
dc.contributor.authorGreen, R. D.en
dc.contributor.authorKouzarides, T.en
dc.creatorKirmizis, Antonisen
dc.creatorSantos-Rosa, H.en
dc.creatorPenkett, C. J.en
dc.creatorSinger, M. A.en
dc.creatorGreen, R. D.en
dc.creatorKouzarides, T.en
dc.date.accessioned2019-11-04T12:51:50Z
dc.date.available2019-11-04T12:51:50Z
dc.date.issued2009
dc.identifier.issn1545-9993
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53174
dc.description.abstractDimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit histone H3 Lys4 (H3K4) methylationen
dc.description.abstract(ii) it is present throughout the coding region of genesen
dc.description.abstractand (iii) it correlates with active transcription. Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression. © 2009 Nature America, Inc. All rights reserved.en
dc.sourceNature Structural and Molecular Biologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-64049102668&doi=10.1038%2fnsmb.1569&partnerID=40&md5=e1ecfd65e78f31a289f26ace20df1396
dc.subjectarticleen
dc.subjectpriority journalen
dc.subjectnonhumanen
dc.subjectgene expressionen
dc.subjecttranscription regulationen
dc.subjectgene mutationen
dc.subjectgene deletionen
dc.subjectnucleotide sequenceen
dc.subjectarginineen
dc.subjectgene activityen
dc.subjectprotein protein interactionen
dc.subjectSaccharomyces cerevisiaeen
dc.subjectprotein processingen
dc.subjecthistone H3en
dc.subjectHistonesen
dc.subjectmethylationen
dc.subjectGene Expression Regulation, Fungalen
dc.subjectsilencer elementen
dc.subjectsporogenesisen
dc.titleDistinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2en
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/nsmb.1569
dc.description.volume16
dc.description.startingpage449
dc.description.endingpage451
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :32</p>en
dc.source.abbreviationNat.Struct.Mol.Biol.en
dc.contributor.orcidKirmizis, Antonis [0000-0002-3748-8711]
dc.gnosis.orcid0000-0002-3748-8711


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