Evidence for recent selection of the CCR5-Δ32 deletion from differences in its frequency between Ashkenazi and Sephardi Jews
dc.contributor.author | Maayan, S. | en |
dc.contributor.author | Zhang, L. | en |
dc.contributor.author | Shinar, E. | en |
dc.contributor.author | Ho, J. | en |
dc.contributor.author | He, T. | en |
dc.contributor.author | Manni, N. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.contributor.author | Neumann, A. U. | en |
dc.creator | Maayan, S. | en |
dc.creator | Zhang, L. | en |
dc.creator | Shinar, E. | en |
dc.creator | Ho, J. | en |
dc.creator | He, T. | en |
dc.creator | Manni, N. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.creator | Neumann, A. U. | en |
dc.date.accessioned | 2019-11-04T12:52:19Z | |
dc.date.available | 2019-11-04T12:52:19Z | |
dc.date.issued | 2000 | |
dc.identifier.issn | 1466-4879 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53234 | |
dc.description.abstract | Recent studies have shown higher frequencies of the CCR5-Δ32 allele and the CCR5-A32/Δ32 genotype, which confers protection against HIV infection, in northern Europe as compared to Mediterranean countries. Here, we analyse the prevalence of CCR5-Δ32 in 922 HIV seronegative blood donors in Israel to verify its frequency in Jews of Ashkenazi and Sephardi origin. A significant difference (P < 0.001) was found between the CCR5-Δ32 allele frequency in Ashkenazi (13.8%) vs (4.9%) Jews. In contrast, no significant difference was observed in the frequency of the CCR2-641 mutation between Ashkenazi (9.2%) and Sephardi (13.4%) Jews. Using the Island model we calculate that a minimal genetic migration rate of 3% per generation would have been necessary if the higher CCR5-Δ32 prevalence in Ashkenazi is to be fully explained by mixing with the indigenous north-European populations. This putative migration rate is 20-fold higher than that currently estimated from other genes, and would correspond to a non-realistic minimal current admixture of 80%. Thus, our results suggest that a positive selection process for CCR5-Δ32 should have occurred in northern Europe at most a 1000 years ago, after the Ashkenazi Jews separated from their Sephardi kin and moved to north Europe. | en |
dc.source | Genes and immunity | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034252519&partnerID=40&md5=b01bf5d4d9887286d1092677b7c11b4f | |
dc.subject | CCR5-Δ32 mutation | el |
dc.subject | Europe | en |
dc.subject | article | en |
dc.subject | Mediterranean Region | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | Human immunodeficiency virus infection | en |
dc.subject | allele | en |
dc.subject | gene frequency | en |
dc.subject | genotype | en |
dc.subject | HIV Infections | en |
dc.subject | comparative study | en |
dc.subject | genetics | en |
dc.subject | Alleles | en |
dc.subject | Base Sequence | en |
dc.subject | DNA Primers | en |
dc.subject | gene deletion | en |
dc.subject | nucleotide sequence | en |
dc.subject | ethnology | en |
dc.subject | primer DNA | en |
dc.subject | Mathematical modeling | en |
dc.subject | Jews | en |
dc.subject | Israel | en |
dc.subject | Sequence Deletion | en |
dc.subject | chemokine receptor CCR5 | en |
dc.subject | Receptors, CCR5 | en |
dc.subject | jew | en |
dc.subject | Southern Europe | en |
dc.subject | Population genetics | en |
dc.subject | CCR2-641 mutation | en |
dc.subject | Genetic polymorphism | en |
dc.subject | genetic selection | en |
dc.subject | HIV-1 co-receptors | en |
dc.subject | Selection (Genetics) | en |
dc.title | Evidence for recent selection of the CCR5-Δ32 deletion from differences in its frequency between Ashkenazi and Sephardi Jews | en |
dc.type | info:eu-repo/semantics/article | |
dc.description.volume | 1 | |
dc.description.startingpage | 358 | |
dc.description.endingpage | 361 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :10</p> | en |
dc.source.abbreviation | Genes Immun. | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 |
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