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dc.contributor.authorPavlopoulos, Eliasen
dc.contributor.authorPitsouli, Chrysoulaen
dc.contributor.authorKlueg, K. M.en
dc.contributor.authorMuskavitch, M. A. T.en
dc.contributor.authorMoschonas, Nicholas K.en
dc.contributor.authorDelidakis, Christosen
dc.creatorPavlopoulos, Eliasen
dc.creatorPitsouli, Chrysoulaen
dc.creatorKlueg, K. M.en
dc.creatorMuskavitch, M. A. T.en
dc.creatorMoschonas, Nicholas K.en
dc.creatorDelidakis, Christosen
dc.date.accessioned2019-11-04T12:52:28Z
dc.date.available2019-11-04T12:52:28Z
dc.date.issued2001
dc.identifier.issn1534-5807
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53295
dc.description.abstractActivation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding by transendocytosing the latter into the signal-emitting cell. We find that Dl endocytosis and N signaling are greatly stimulated by expression of neuralized (neur). neur inactivation suppresses Dl endocytosis, while its overexpression enhances Dl endocytosis and Notch-dependent signaling. We show that neur encodes an intracellular peripheral membrane protein. Its C-terminal RING domain is necessary for Dl accumulation in endosomes, but may be dispensable for Dl signaling. The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups. © 2001 Cell Press.en
dc.sourceDevelopmental Cellen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0035653308&doi=10.1016%2fS1534-5807%2801%2900093-4&partnerID=40&md5=c62d0caf754a9611131e98a85e3d8cdd
dc.subjectarticleen
dc.subjectsignal transductionen
dc.subjectmetabolismen
dc.subjectproteinen
dc.subjectanimalen
dc.subjectgeneticsen
dc.subjectphysiologyen
dc.subjectMembrane Proteinsen
dc.subjectmembrane proteinen
dc.subjectcytologyen
dc.subjectprotein tertiary structureen
dc.subjectendocytosisen
dc.subjectDrosophila melanogasteren
dc.subjectSupport, Non-U.S. Gov'ten
dc.subjectDrosophila Proteinsen
dc.subjectforelimben
dc.subjectWingen
dc.subjectDrosophila proteinen
dc.subjectSupport, U.S. Gov't, P.H.S.en
dc.subjectembryologyen
dc.subjecthybrid proteinen
dc.subjectRecombinant Fusion Proteinsen
dc.subjectphotoreceptoren
dc.subjectNerve Tissue Proteinsen
dc.subjectProtein Structure, Tertiaryen
dc.subjectMicroscopy, Fluorescenceen
dc.subjectGenes, Reporteren
dc.subjectreporter geneen
dc.subjectnerve proteinen
dc.subjectfluorescence microscopyen
dc.subjectembryonic structuresen
dc.subjectneu protein, Drosophilaen
dc.subjectPhotoreceptors, Invertebrateen
dc.titleNeuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosisen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/S1534-5807(01)00093-4
dc.description.volume1
dc.description.startingpage807
dc.description.endingpage816
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :202</p>en
dc.source.abbreviationDev.Cellen
dc.contributor.orcidPitsouli, Chrysoula [0000-0003-4074-9684]
dc.gnosis.orcid0000-0003-4074-9684


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