Neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis
dc.contributor.author | Pavlopoulos, Elias | en |
dc.contributor.author | Pitsouli, Chrysoula | en |
dc.contributor.author | Klueg, K. M. | en |
dc.contributor.author | Muskavitch, M. A. T. | en |
dc.contributor.author | Moschonas, Nicholas K. | en |
dc.contributor.author | Delidakis, Christos | en |
dc.creator | Pavlopoulos, Elias | en |
dc.creator | Pitsouli, Chrysoula | en |
dc.creator | Klueg, K. M. | en |
dc.creator | Muskavitch, M. A. T. | en |
dc.creator | Moschonas, Nicholas K. | en |
dc.creator | Delidakis, Christos | en |
dc.date.accessioned | 2019-11-04T12:52:28Z | |
dc.date.available | 2019-11-04T12:52:28Z | |
dc.date.issued | 2001 | |
dc.identifier.issn | 1534-5807 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53295 | |
dc.description.abstract | Activation of the Notch (N) receptor involves an intracellular proteolytic step triggered by shedding of the extracellular N domain (N-EC) upon ligand interaction. The ligand Dl has been proposed to effect this N-EC shedding by transendocytosing the latter into the signal-emitting cell. We find that Dl endocytosis and N signaling are greatly stimulated by expression of neuralized (neur). neur inactivation suppresses Dl endocytosis, while its overexpression enhances Dl endocytosis and Notch-dependent signaling. We show that neur encodes an intracellular peripheral membrane protein. Its C-terminal RING domain is necessary for Dl accumulation in endosomes, but may be dispensable for Dl signaling. The potent modulatory effect of Neur on Dl activity makes Neur a candidate for establishing signaling asymmetries within cellular equivalence groups. © 2001 Cell Press. | en |
dc.source | Developmental Cell | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035653308&doi=10.1016%2fS1534-5807%2801%2900093-4&partnerID=40&md5=c62d0caf754a9611131e98a85e3d8cdd | |
dc.subject | article | en |
dc.subject | signal transduction | en |
dc.subject | metabolism | en |
dc.subject | protein | en |
dc.subject | animal | en |
dc.subject | genetics | en |
dc.subject | physiology | en |
dc.subject | Membrane Proteins | en |
dc.subject | membrane protein | en |
dc.subject | cytology | en |
dc.subject | protein tertiary structure | en |
dc.subject | endocytosis | en |
dc.subject | Drosophila melanogaster | en |
dc.subject | Support, Non-U.S. Gov't | en |
dc.subject | Drosophila Proteins | en |
dc.subject | forelimb | en |
dc.subject | Wing | en |
dc.subject | Drosophila protein | en |
dc.subject | Support, U.S. Gov't, P.H.S. | en |
dc.subject | embryology | en |
dc.subject | hybrid protein | en |
dc.subject | Recombinant Fusion Proteins | en |
dc.subject | photoreceptor | en |
dc.subject | Nerve Tissue Proteins | en |
dc.subject | Protein Structure, Tertiary | en |
dc.subject | Microscopy, Fluorescence | en |
dc.subject | Genes, Reporter | en |
dc.subject | reporter gene | en |
dc.subject | nerve protein | en |
dc.subject | fluorescence microscopy | en |
dc.subject | embryonic structures | en |
dc.subject | neu protein, Drosophila | en |
dc.subject | Photoreceptors, Invertebrate | en |
dc.title | Neuralized Encodes a Peripheral Membrane Protein Involved in Delta Signaling and Endocytosis | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1016/S1534-5807(01)00093-4 | |
dc.description.volume | 1 | |
dc.description.startingpage | 807 | |
dc.description.endingpage | 816 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :202</p> | en |
dc.source.abbreviation | Dev.Cell | en |
dc.contributor.orcid | Pitsouli, Chrysoula [0000-0003-4074-9684] | |
dc.gnosis.orcid | 0000-0003-4074-9684 |
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