Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
Date
1993Author
Peters, D. J. M.Spruit, L.
Saris, J. J.
Ravine, D.
Sandkuijl, L. A.
Fossdal, R.
Boersma, J.
van Eijk, R.
Nørby, S.
Constantinou-Deltas, Constantinos D.
Pierides, Alkis M.
Briessenden, J. E.
Frants, R. R.
van Ommen, G. -J B.
Breuning, M. H.
ISSN
1061-4036Source
Nature geneticsVolume
5Pages
359-362Google Scholar check
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Metadata
Show full item recordAbstract
Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. A gene defect located on the short arm of chromosome 16 is responsible for the disease in roughly 86% of affected European families. Using highly polymorphic microsatellite DNA markers, we have assigned a second gene for ADPKD to chromosome 4. In eight families with clear evidence against linkage to chromosome 16 markers, linkage analysis with the markers D4S231 and D4S423, demonstrated a multipoint lod score of 22.42. © 1993 Nature Publishing Group.