Chromosome 4 localization of a second gene for autosomal dominant polycystic kidney disease
AuthorPeters, D. J. M.
Saris, J. J.
Sandkuijl, L. A.
van Eijk, R.
Constantinou-Deltas, Constantinos D.
Pierides, Alkis M.
Briessenden, J. E.
Frants, R. R.
van Ommen, G. -J B.
Breuning, M. H.
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Autosomal dominant polycystic kidney disease (ADPKD) is a genetically heterogeneous disorder. A gene defect located on the short arm of chromosome 16 is responsible for the disease in roughly 86% of affected European families. Using highly polymorphic microsatellite DNA markers, we have assigned a second gene for ADPKD to chromosome 4. In eight families with clear evidence against linkage to chromosome 16 markers, linkage analysis with the markers D4S231 and D4S423, demonstrated a multipoint lod score of 22.42. © 1993 Nature Publishing Group.
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