dc.contributor.author | Petridou, E. | en |
dc.contributor.author | Klimentopoulou, A. E. | en |
dc.contributor.author | Moustaki, M. | en |
dc.contributor.author | Kostrikis, Leontios G. | en |
dc.contributor.author | Hatzakis, Angelos E. | en |
dc.contributor.author | Trichopoulos, D. | en |
dc.creator | Petridou, E. | en |
dc.creator | Klimentopoulou, A. E. | en |
dc.creator | Moustaki, M. | en |
dc.creator | Kostrikis, Leontios G. | en |
dc.creator | Hatzakis, Angelos E. | en |
dc.creator | Trichopoulos, D. | en |
dc.date.accessioned | 2019-11-04T12:52:28Z | |
dc.date.available | 2019-11-04T12:52:28Z | |
dc.date.issued | 2002 | |
dc.identifier.uri | http://gnosis.library.ucy.ac.cy/handle/7/53301 | |
dc.description.abstract | The concentration of T-cell receptor rearrangement excision DNA circles (TRECs) in peripheral blood mononuclear cells (PBMCs) is currently known to be a marker of recent thymic emigrants. We evaluated the hypothesis that TREC values would be lower in childhood T-cell hematopoietic malignancies than in childhood B-cell acute lymphoblastic leukemia (ALL) or healthy controls because the former category may reflect compromised thymic function. From the Greek national childhood leukemia/lymphoma database we obtained all 30 available T-cell leukemia/non-Hodgkin's lymphoma cases, 30 age- and sex-matched childhood B-cell origin cases of ALL and 60 healthy hospital controls. We compared TREC levels in PBMCs using a real-time PCR assay. There was highly significant reduction of TREC values in children with T-cell malignancies (median 3,100 TRECs/106 PBMCs), whereas children with B-cell origin ALL had slightly but nonsignificantly lower TREC values compared to healthy children (medians 19,300 and 22,500 TRECs/106 PBMCs, respectively). During a median follow-up period of about 19 months, only 4 children died. All of them had a T-cell hematopoietic malignancy and relatively low TREC values. The number of TRECs was higher among healthy girls than among healthy boys, and a similar pattern was evident in T-cell malignancies. It appears that there is a pattern of concordance of high TREC values with better disease prognosis in hematologic childhood malignancies. This applies to specific disease entities with better prognosis (B-cell origin ALL having higher TREC values than T-cell leukemia/lymphoma) and to gender, another important predictor of prognosis conditional on disease entity (girls having higher TREC values than boys) | en |
dc.description.abstract | however, it may also be true for the survival of individual patients. These preliminary findings can be used as hypothesis-generating indications that should be confirmed in larger data sets. © 2002 Wiley-Liss, Inc. | en |
dc.source | International Journal of Cancer | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036722798&doi=10.1002%2fijc.10568&partnerID=40&md5=900a944637a0986170e7c8535f8630d2 | |
dc.subject | article | en |
dc.subject | human | en |
dc.subject | Humans | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | major clinical study | en |
dc.subject | follow up | en |
dc.subject | priority journal | en |
dc.subject | prognosis | en |
dc.subject | Survival Rate | en |
dc.subject | nonhodgkin lymphoma | en |
dc.subject | male | en |
dc.subject | Lymphoma | en |
dc.subject | Child | en |
dc.subject | T-Lymphocytes | en |
dc.subject | DNA | en |
dc.subject | polymerase chain reaction | en |
dc.subject | Leukemia | en |
dc.subject | school child | en |
dc.subject | Cell Movement | en |
dc.subject | DNA, Neoplasm | en |
dc.subject | thymus | en |
dc.subject | Thymus Gland | en |
dc.subject | Receptors, Antigen, T-Cell | en |
dc.subject | T lymphocyte receptor | en |
dc.subject | Gene Rearrangement, T-Lymphocyte | en |
dc.subject | Age of Onset | en |
dc.subject | Acute lymphoblastic leukemia | en |
dc.subject | B cell leukemia | en |
dc.subject | B-Lymphocytes | en |
dc.subject | childhood leukemia | en |
dc.subject | Leukemia, Lymphocytic, Acute | en |
dc.subject | Sex Characteristics | en |
dc.subject | T cell leukemia | en |
dc.subject | T-cell receptor rearrangement excision circle | en |
dc.subject | Thymic emigrant | en |
dc.title | Recent thymic emigrants and prognosis in T- and B-cell childhood hematopoietic malignancies | en |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | 10.1002/ijc.10568 | |
dc.description.volume | 101 | |
dc.description.startingpage | 74 | |
dc.description.endingpage | 77 | |
dc.author.faculty | Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences | |
dc.author.department | Τμήμα Βιολογικών Επιστημών / Department of Biological Sciences | |
dc.type.uhtype | Article | en |
dc.description.notes | <p>Cited By :21</p> | en |
dc.source.abbreviation | Int.J.Cancer | en |
dc.contributor.orcid | Kostrikis, Leontios G. [0000-0002-5340-7109] | |
dc.gnosis.orcid | 0000-0002-5340-7109 | |