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Vernonia kotschyana roots: Therapeutic potential via antioxidant activity

dc.contributor.authorVasincu, A.en
dc.contributor.authorPaulsen, B. S.en
dc.contributor.authorDiallo, D.en
dc.contributor.authorVasincu, I.en
dc.contributor.authorAprotosoaie, A. C.en
dc.contributor.authorBild, V.en
dc.contributor.authorCharalambous, Christinaen
dc.contributor.authorConstantinou, Andreas I.en
dc.contributor.authorMiron, A.en
dc.contributor.authorGavrilescu, C. M.en
dc.creatorVasincu, A.en
dc.creatorPaulsen, B. S.en
dc.creatorDiallo, D.en
dc.creatorVasincu, I.en
dc.creatorAprotosoaie, A. C.en
dc.creatorBild, V.en
dc.creatorCharalambous, Christinaen
dc.creatorConstantinou, Andreas I.en
dc.creatorMiron, A.en
dc.creatorGavrilescu, C. M.en
dc.date.accessioned2019-11-04T12:52:48Z
dc.date.available2019-11-04T12:52:48Z
dc.date.issued2014
dc.identifier.issn1420-3049
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/53429
dc.description.abstractThe roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine in the treatment of gastroduodenal ulcers and gastritis. Since oxidative stress is involved in gastric ulceration, the aim of this study was to screen the root extracts for their in vitro antioxidant activity and phenolic content. The roots were extracted successively with chloroform, ethyl acetate, ethanol and water. The antioxidant activity of root extracts was evaluated in both cell-free and cell-based assays. Their chemical characterization was performed by Fourier transform infrared spectroscopy (FT-IR) whereas the total phenolic content was determined by the Folin-Ciocalteu method. The ethyl acetate extract displayed the highest phenolic content and was found to be the most active in the free radical scavenging and lipid peroxidation inhibition assaysen
dc.description.abstractit also showed a high antioxidant activity in MCF-12F cells. This study suggests a potential use of the ethyl acetate extract of Vernonia kotschyana not only as an antioxidant agent in gastroduodenal ulcers and gastritis, but also in other disorders characterized by high levels of oxidative stress. © 2014 by the authors.en
dc.sourceMoleculesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84911999093&doi=10.3390%2fmolecules191119114&partnerID=40&md5=9006031096d00b8e424139aac799c92d
dc.subjecthumanen
dc.subjectHumansen
dc.subjectlipid peroxidationen
dc.subjectoxidative stressen
dc.subjectgastritisen
dc.subjectstomach ulceren
dc.subjectchemistryen
dc.subjectplant extracten
dc.subjectdrug effectsen
dc.subjectAntioxidantsen
dc.subjectPhenolsen
dc.subjectphenol derivativeen
dc.subjectFree Radical Scavengersen
dc.subjectPlant Extractsen
dc.subjectplant rooten
dc.subjectscavengeren
dc.subjectantioxidanten
dc.subjectcell lineen
dc.subjectEthyl acetate extracten
dc.subjectFree radical scavenging activityen
dc.subjectFT-IR spectroscopyen
dc.subjectLipid peroxidation inhibitionen
dc.subjectPhenolic contenten
dc.subjectPlant Rootsen
dc.subjectVernoniaen
dc.subjectVernonia kotschyanaen
dc.titleVernonia kotschyana roots: Therapeutic potential via antioxidant activityen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/molecules191119114
dc.description.volume19
dc.description.startingpage19114
dc.description.endingpage19136
dc.author.facultyΣχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Βιολογικών Επιστημών / Department of Biological Sciences
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :2</p>en
dc.source.abbreviationMoleculesen
dc.contributor.orcidConstantinou, Andreas I. [0000-0003-0365-1821]
dc.gnosis.orcid0000-0003-0365-1821


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