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Type 2 diabetes susceptibility in the Greek-Cypriot population: Replication of associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 polymorphisms

dc.contributor.authorVotsi, C.en
dc.contributor.authorToufexis, C.en
dc.contributor.authorMichailidou, K.en
dc.contributor.authorAntoniades, Athosen
dc.contributor.authorSkordis, Nicos A.en
dc.contributor.authorKaraolis, Minas A.en
dc.contributor.authorPattichis, Constantinos S.en
dc.contributor.authorChristodoulou, Kyproulaen
dc.creatorVotsi, C.en
dc.creatorToufexis, C.en
dc.creatorMichailidou, K.en
dc.creatorAntoniades, Athosen
dc.creatorSkordis, Nicos A.en
dc.creatorKaraolis, Minas A.en
dc.creatorPattichis, Constantinos S.en
dc.creatorChristodoulou, Kyproulaen
dc.date.accessioned2019-11-13T10:42:59Z
dc.date.available2019-11-13T10:42:59Z
dc.date.issued2017
dc.identifier.issn2073-4425
dc.identifier.urihttp://gnosis.library.ucy.ac.cy/handle/7/55146
dc.description.abstractType 2 diabetes (T2D) has been the subject of numerous genetic studies in recent years which revealed associations of the disease with a large number of susceptibility loci. We hereby initiate the evaluation of T2D susceptibility loci in the Greek-Cypriot population by performing a replication case-control study. One thousand and eighteen individuals (528 T2D patients, 490 controls) were genotyped at 21 T2D susceptibility loci, using the allelic discrimination method. Statistically significant associations of T2D with five of the tested single nucleotide polymorphisms (SNPs) (TCF7L2 rs7901695, FTO rs8050136, HHEX rs5015480, SLC30A8 rs13266634 and IGF2BP2 rs4402960) were observed in this study population. Furthermore, 14 of the tested SNPs had odds ratios (ORs) in the same direction as the previously published studies, suggesting that these variants can potentially be used in the Greek-Cypriot population for predictive testing of T2D. In conclusion, our findings expand the genetic assessment of T2D susceptibility loci and reconfirm five of the worldwide established loci in a distinct, relatively small, newly investigated population. © 2017 by the authorsen
dc.description.abstractlicensee MDPI, Basel, Switzerland.en
dc.sourceGenesen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85009758624&doi=10.3390%2fgenes8010016&partnerID=40&md5=eedfa3403fc982447fc2aaa3b8c6ad8c
dc.subjecthumanen
dc.subjectadulten
dc.subjectcontrolled studyen
dc.subjectfemaleen
dc.subjectmajor clinical studyen
dc.subjectpredictionen
dc.subjectmaleen
dc.subjectalleleen
dc.subjectcase control studyen
dc.subjectgeneen
dc.subjectsingle nucleotide polymorphismen
dc.subjectgenetic susceptibilityen
dc.subjectgenotypeen
dc.subjectdisease associationen
dc.subjectArticleen
dc.subjectgene locusen
dc.subjectnon insulin dependent diabetes mellitusen
dc.subjectType 2 diabetesen
dc.subjectCyprioten
dc.subjectpopulation geneticsen
dc.subjectGreek (people)en
dc.subjectAssociation studiesen
dc.subjectFTO geneen
dc.subjectgene replicationen
dc.subjectGreek-cypriot populationen
dc.subjectHHEX geneen
dc.subjectIGF2BP2 geneen
dc.subjectPopulation studiesen
dc.subjectSLC30A8 geneen
dc.subjectSusceptibility locien
dc.subjectTCF7L2 geneen
dc.subjecttranscription factor 7 like 2en
dc.titleType 2 diabetes susceptibility in the Greek-Cypriot population: Replication of associations with TCF7L2, FTO, HHEX, SLC30A8 and IGF2BP2 polymorphismsen
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/genes8010016
dc.description.volume8
dc.description.issue1
dc.author.faculty002 Σχολή Θετικών και Εφαρμοσμένων Επιστημών / Faculty of Pure and Applied Sciences
dc.author.departmentΤμήμα Πληροφορικής / Department of Computer Science
dc.type.uhtypeArticleen
dc.description.notes<p>Cited By :1</p>en
dc.source.abbreviationGenesen
dc.contributor.orcidPattichis, Constantinos S. [0000-0003-1271-8151]
dc.gnosis.orcid0000-0003-1271-8151


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