Effects of monovalent anions of the Hofmeister series on DPPC lipid bilayers part I: Swelling and in-plane equations of state
Google Scholar check
MetadataShow full item record
Aiming to improve understanding of the mechanisms behind specific anion effects in biological systems we have studied the effects of sodium salts of simple monovalent anions belonging to the Hofmeister series on the bilayers of the zwitterionic lipid 1,2-dipalmitoyl-sn-glycero-3-phosphocholine using small-angle x-ray scattering and the osmotic stress technique. NaCl, NaBr, NaNO3, NaI, and NaSCN were used in this investigation. The electrolytes were found to swell the bilayers and to increase the area per lipid headgroup at each value of the osmotic pressure, suggesting the association of anions with the bilayer-lipid interfaces. The effects follow the Hofmeister series with SCN- inducing the most pronounced changes. "Ion competition" experiments with mixed NaI/NaCl solutions at total salinity 0.1 and 0.5 M revealed that the effect of ions on the lipid equation-of-state is roughly linear at low concentrations, but strongly nonlinear at high concentrations. The experimental results are fitted in a companion article to provide "binding or "partitioning" constants of anions in the lipid bilayers. © 2007 by the Biophysical Society.
Showing items related by title, author, creator and subject.
Simultaneous determination of nine acetylcholinesterase inhibitors using micellar electrokinetic chromatography Nicolaou, I. N.; Kapnissi‐Christodoulou, Constantina P. (2011)MEKC was used for the separation of nine acetylcholinesterase inhibitors (AChEIs). AChEIs are an important group of drug compounds that are used medicinally to treat Alzheimer's disease and Myasthenia Gravis. At the time ...
Evaluation of amino acid ester-based ionic liquids as buffer additives in CE for the separation of 2-arylpropionic acids nonsteroidal anti-inflammatory drugs Mavroudi, Maria C.; Kapnissi‐Christodoulou, Constantina P. (2014)The aim of the present study is the CE performance evaluation for the separation of 2-arylpropionic acid nonsteroidal anti-inflammatory drugs. In particular, the separation of indoprofen, carprofen, ketoprofen, ibuprofen, ...
Liquid expanded monolayers of lipids as model systems to understand the anionic hofmeister series: 1. A tale of models Leontidis, Epameinondas; Aroti, Andria; Belloni, L. (2009)In this work, we use Langmuir monolayers of dipalmitoyl phosphatidylcholine (DPPC) as model systems to enhance the understanding of specific anion effects in physicochemical and biological systems. The 298 K isotherms ...